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Ganzkörper-MRT bei Tumorprädispositionssyndromen

Whole-body MRI in cancer predisposition syndromes

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Zusammenfassung

Hintergrund

In den vergangenen Jahrzehnten hat sich die Ganzkörper-Magnetresonanztomographie (GK-MRT) für die Diagnose, das Staging und die Nachsorge onkologischer Erkrankungen sowie zum Screening bei Tumorprädispositionssyndromen (TPS), wie dem Li-Fraumeni-Syndrom, etabliert. Als umfassende Bildgebungsmethode ohne ionisierende Strahlung kann die GK-MRT beliebig häufig wiederholt eingesetzt werden und bietet aufgrund des ausgezeichneten Weichteilkontrasts und der hohen Auflösung eine frühzeitige, präzise Erkennung von Pathologien.

Methoden

Auf die technischen Voraussetzungen, einige Untersuchungsstrategien sowie die klinische Bedeutung typischer Befunde der GK-MRT-Bildgebung bei Patient:innen mit TPS wird in diesem Beitrag eingegangen.

Abstract

Background

In recent decades, whole-body magnetic resonance imaging (WB-MRI) has become established as the modality of choice for the diagnosis, staging, and follow-up of oncological diseases as well as for the screening of cancer predisposition syndromes, such as Li-Fraumeni syndrome.

Methods

As a comprehensive imaging modality without ionizing radiation, WB-MRI can be used repetitively and because of its excellent soft tissue contrast and high resolution provides early and precise detection of pathologies. This article discusses the technical requirements, some examination strategies and the clinical significance of typical findings of WB-MRI in patients with cancer predisposition syndromes.

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Authors and Affiliations

  1. Abteilung für Diagnostische und Interventionelle Radiologie, Universitätsklinikum Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Deutschland

    Judith Herrmann, Michael Esser, Ilias Tsiflikas & Jürgen F. Schäfer

  2. Klinik für Kinder- und Jugendmedizin, Universitätsklinikum Tübingen, Tübingen, Deutschland

    Ines Brecht

Authors
  1. Judith Herrmann
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  2. Michael Esser
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  4. Ilias Tsiflikas
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  5. Jürgen F. Schäfer
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Correspondence to Judith Herrmann.

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Interessenkonflikt

J. Herrmann, M. Esser, I. Brecht, I. Tsiflikas und J.F. Schäfer geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autor/-innen keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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Herrmann, J., Esser, M., Brecht, I. et al. Ganzkörper-MRT bei Tumorprädispositionssyndromen. Radiologie 62, 1017–1025 (2022). https://doi.org/10.1007/s00117-022-01067-7

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  • DOI: https://doi.org/10.1007/s00117-022-01067-7

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