Zusammenfassung
Die funktionelle MRT der Nieren hat in den letzten Jahren zunehmend an Bedeutung gewonnen. In diesem Übersichtsartikel werden die wichtigsten funktionellen Untersuchungstechniken vorgestellt und deren potenzielle klinische Bedeutung zur Evaluation von Nieren und Transplantatnieren hervorgehoben, wobei ein besonderes Augenmerk auf die Abklärung von Nierentumoren gelegt wird.
Abstract
Interest in functional renal magnetic resonance imaging (MRI) has significantly increased in recent years. This review article provides an overview of the most important functional imaging techniques and their potential clinical applications for assessment of native and transplanted kidneys, with special emphasis on the clarification of renal tumors.
Literatur
Grenier N, Basseau F, Ries M, Tyndal B, Jones R, Moonen C (2003) Functional MRI of the kidney. Abdom Imaging 28:164–175
Sourbron SP, Michaely HJ, Reiser MF, Schoenberg SO (2008) MRI-measurement of perfusion and glomerular filtration in the human kidney with a separable compartment model. Invest Radiol 43:40–48
Hackstein N, Kooijman H, Tomaselli S, Rau WS (2005) Glomerular filtration rate measured using the Patlak plot technique and contrast-enhanced dynamic MRI with different amounts of gadolinium-DTPA. J Magn Reson Imaging 22:406–414
Bokacheva L, Rusinek H, Zhang JL, Chen Q, Lee VS (2009) Estimates of glomerular filtration rate from MR renography and tracer kinetic models. J Magn Reson Imaging 29:371–382
Roditi G, Maki JH, Oliveira G, Michaely HJ (2009) Renovascular imaging in the NSF Era. J Magn Reson Imaging 30:1323–1334
Lee VS, Rusinek H, Bokacheva L et al (2007) Renal function measurements from MR renography and a simplified multicompartmental model. Am J Physiol Renal Physiol 292:F1548–1559
Grenier N, Mendichovszky I, de Senneville BD et al (2008) Measurement of glomerular filtration rate with magnetic resonance imaging: principles, limitations, and expectations. Semin Nucl Med 38:47–55
Boss A, Martirosian P, Gehrmann M et al (2007) Quantitative assessment of glomerular filtration rate with MR gadolinium slope clearance measurements: a phase I trial. Radiology 242:783–790
Mendichovszky I, Pedersen M, Frokiaer J et al (2008) How accurate is dynamic contrast-enhanced MRI in the assessment of renal glomerular filtration rate? A critical appraisal. J Magn Reson Imaging 27:925–931
Winter KS, Helck AD, Ingrisch M et al (2014) Dynamic contrast-enhanced magnetic resonance imaging assessment of kidney function and renal masses: single slice versus whole organ/tumor. Invest Radiol 49:720–727
Michaely HJ, Sourbron SP, Buettner C, Lodemann KP, Reiser MF, Schoenberg SO (2008) Temporal constraints in renal perfusion imaging with a 2-compartment model. Invest Radiol 43:120–128
Hackstein N, Heckrodt J, Rau WS (2003) Measurement of single-kidney glomerular filtration rate using a contrast-enhanced dynamic gradient-echo sequence and the Rutland-Patlak plot technique. J Magn Reson Imaging 18:714–725
Buckley DL, Shurrab AE, Cheung CM, Jones AP, Mamtora H, Kalra PA (2006) Measurement of single kidney function using dynamic contrast-enhanced MRI: comparison of two models in human subjects. J Magn Reson Imaging 24:1117–1123
Baumann D, Rudin M (2000) Quantitative assessment of rat kidney function by measuring the clearance of the contrast agent Gd(DOTA) using dynamic MRI. Magn Reson Imaging 18:587–595
Zhang JL, Rusinek H, Bokacheva L et al (2008) Functional assessment of the kidney from magnetic resonance and computed tomography renography: impulse retention approach to a multicompartment model. Magn Reson Med 59:278–288
Attenberger UI, Sourbron SP, Notohamiprodjo M et al (2008) MR-based semi-automated quantification of renal functional parameters with a two-compartment model – an interobserver analysis. Eur J Radiol 65:59–65
Mendichovszky IA, Cutajar M, Gordon I (2008) Reproducibility of the aortic input function (AIF) derived from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of the kidneys in a volunteer study. Eur J Radiol 71(3):576–581
Lee VS, Rusinek H, Noz ME, Lee P, Raghavan M, Kramer EL (2003) Dynamic three-dimensional MR renography for the measurement of single kidney function: initial experience. Radiology 227:289–294
Lim SW, Chrysochou C, Buckley DL, Kalra PA, Sourbron SP (2013) Prediction and assessment of responses to renal artery revascularization with dynamic contrast-enhanced magnetic resonance imaging: a pilot study. Am J Physiol Renal Physiol 305:F672–F678
Investigators A, Wheatley K, Ives N et al (2009) Revascularization versus medical therapy for renal-artery stenosis. N Engl J Med 361:1953–1962
Kang SK, Huang WC, Wong S et al (2013) Dynamic contrast-enhanced magnetic resonance imaging measurement of renal function in patients undergoing partial nephrectomy: preliminary experience. Invest Radiol 48:687–692
Zollner FG, Zimmer F, Klotz S, Hoeger S, Schad LR (2014) Renal perfusion in acute kidney injury with DCE-MRI: deconvolution analysis versus two-compartment filtration model. Magn Reson Imaging 32:781–785
Zollner FG, Zimmer F, Klotz S, Hoeger S, Schad LR (2015) Functional imaging of acute kidney injury at 3 Tesla: investigating multiple parameters using DCE-MRI and a two-compartment filtration model. Z Med Phys 25:58–65
Michaely HJ, Schoenberg SO, Ittrich C, Dikow R, Bock M, Guenther M (2004) Renal disease: value of functional magnetic resonance imaging with flow and perfusion measurements. Invest Radiol 39:698–705
Attenberger UI, Sourbron SP, Schoenberg SO et al (2010) Comprehensive MR evaluation of renal disease: added clinical value of quantified renal perfusion values over single MR angiography. J Magn Reson Imaging 31:125–133
Szolar DH, Preidler K, Ebner F et al (1997) Functional magnetic resonance imaging of human renal allografts during the post-transplant period: preliminary observations. Magn Reson Imaging 15:727–735
Wentland AL, Sadowski EA, Djamali A, Grist TM, Becker BN, Fain SB (2009) Quantitative MR measures of intrarenal perfusion in the assessment of transplanted kidneys: initial experience. Acad Radiol 16:1077–1085
Yamamoto A, Zhang JL, Rusinek H et al (2011) Quantitative evaluation of acute renal transplant dysfunction with low-dose three-dimensional MR renography. Radiology 260:781–789
Chandarana H, Amarosa A, Huang WC et al (2013) High temporal resolution 3D gadolinium-enhanced dynamic MR imaging of renal tumors with pharmacokinetic modeling: preliminary observations. J Magn Reson Imaging 38:802–808
Notohamiprodjo M, Sourbron S, Staehler M et al (2010) Measuring perfusion and permeability in renal cell carcinoma with dynamic contrast-enhanced MRI: a pilot study. J Magn Reson Imaging 31(2):490–501
Scialpi M, Brunese L, Piscioli I, Rotondo A (2009) Dynamic contrast-enhanced MR imaging for differentiation of renal cell carcinoma subtypes: myth or reality? Radiology 252:929
Sun MR, Ngo L, Genega EM et al (2009) Renal cell carcinoma: dynamic contrast-enhanced MR imaging for differentiation of tumor subtypes – correlation with pathologic findings. Radiology 250:793–802
Sevcenco S, Ponhold L, Javor D et al (2014) Three-Tesla dynamic contrast-enhanced MRI: a critical assessment of its use for differentiation of renal lesion subtypes. World J Urol 32:215–220
Flaherty KT, Rosen MA, Heitjan FH et al (2008) Pilot study of DCE-MRI to predict progression-free survival with sorafenib therapy in renal cell carcinoma. Cancer Biol Ther 7:496–501
Hahn OM, Yang C, Medved M et al (2008) Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma. J Clin Oncol 26:4572–4578
Martirosian P, Boss A, Schraml C et al (2010) Magnetic resonance perfusion imaging without contrast media. Eur J Nucl Med Mol Imaging 37(Suppl 1):52–64
Detre JA, Leigh JS, Williams DS, Koretsky AP (1992) Perfusion imaging. Magn Reson Med 23:37–45
Wong EC, Buxton RB, Frank LR (1997) Implementation of quantitative perfusion imaging techniques for functional brain mapping using pulsed arterial spin labeling. NMR Biomed 10:237–249
Artz NS, Sadowski EA, Wentland AL et al (2011) Reproducibility of renal perfusion MR imaging in native and transplanted kidneys using non-contrast arterial spin labeling. J Magn Reson Imaging 33:1414–1421
Fenchel M, Martirosian P, Langanke J et al (2006) Perfusion MR imaging with FAIR true FISP spin labeling in patients with and without renal artery stenosis: initial experience. Radiology 238:1013–1021
Lanzman RS, Wittsack HJ, Martirosian P et al (2010) Quantification of renal allograft perfusion using arterial spin labeling MRI: initial results. Eur Radiol 20:1485–1491
Martirosian P, Klose U, Mader I, Schick F (2004) FAIR true-FISP perfusion imaging of the kidneys. Magn Reson Med 51:353–361
Heusch P, Wittsack HJ, Blondin D et al (2014) Functional evaluation of transplanted kidneys using arterial spin labeling MRI. J Magn Reson Imaging 40:84–89
Artz NS, Wentland AL, Sadowski EA et al (2011) Comparing kidney perfusion using noncontrast arterial spin labeling MRI and microsphere methods in an interventional swine model. Invest Radiol 46:124–131
Winter JD, St Lawrence KS, Cheng HL (2011) Quantification of renal perfusion: comparison of arterial spin labeling and dynamic contrast-enhanced MRI. J Magn Reson Imaging 34:608–615
Artz NS, Sadowski EA, Wentland AL et al (2011) Arterial spin labeling MRI for assessment of perfusion in native and transplanted kidneys. Magn Reson Imaging 29:74–82
Hueper K, Gueler F, Brasen JH et al (2015) Functional MRI detects perfusion impairment in renal allografts with delayed graft function. Am J Physiol Renal Physiol 308:F1444–F1451
Lanzman RS, Robson PM, Sun MR et al (2012) Arterial spin-labeling MR imaging of renal masses: correlation with histopathologic findings. Radiology 265:799–808
Liu YP, Song R, Liang C, Chen X, Liu B (2012) Arterial spin labeling blood flow magnetic resonance imaging for evaluation of renal injury. Am J Physiol Renal Physiol 303:F551–F558
Tan H, Thacker J, Franklin T, Prasad PV (2015) Sensitivity of arterial spin labeling perfusion MRI to pharmacologically induced perfusion changes in rat kidneys. J Magn Reson Imaging 41:1124–1128
Pedrosa I, Rafatzand K, Robson P et al (2011) Arterial spin labeling MR imaging for characterisation of renal masses in patients with impaired renal function: initial experience. Eur Radiol 265(3):799–808
Schor-Bardach R, Alsop DC, Pedrosa I et al (2009) Does arterial spin-labeling MR imaging-measured tumor perfusion correlate with renal cell cancer response to antiangiogenic therapy in a mouse model? Radiology 251:731–742
de Bazelaire C, Alsop DC, George D et al (2008) Magnetic resonance imaging-measured blood flow change after antiangiogenic therapy with PTK787/ZK 222584 correlates with clinical outcome in metastatic renal cell carcinoma. Clin Cancer Res 14:5548–5554
Notohamiprodjo M, Reiser MF, Sourbron SP (2010) Diffusion and perfusion of the kidney. Eur J Radiol 76:337–347
Thoeny HC, De Keyzer F (2011) Diffusion-weighted MR imaging of native and transplanted kidneys. Radiology 259:25–38
Wittsack HJ, Lanzman RS, Mathys C, Janssen H, Modder U, Blondin D (2010) Statistical evaluation of diffusion-weighted imaging of the human kidney. Magn Reson Med 64:616–622
Zhang JL, Sigmund EE, Chandarana H et al (2010) Variability of renal apparent diffusion coefficients: limitations of the monoexponential model for diffusion quantification. Radiology 254:783–792
Le Bihan D, Breton E, Lallemand D, Grenier P, Cabanis E, Laval-Jeantet M (1986) MR imaging of intravoxel incoherent motions: application to diffusion and perfusion in neurologic disorders. Radiology 161:401–407
Heusch P, Wittsack HJ, Heusner T et al (2013) Correlation of biexponential diffusion parameters with arterial spin-labeling perfusion MRI: results in transplanted kidneys. Invest Radiol 48:140–144
Wittsack HJ, Lanzman RS, Quentin M et al (2012) Temporally resolved electrocardiogram-triggered diffusion-weighted imaging of the human kidney: correlation between intravoxel incoherent motion parameters and renal blood flow at different time points of the cardiac cycle. Invest Radiol 47:226–230
Heusch P, Wittsack HJ, Pentang G et al (2013) Biexponential analysis of diffusion-weighted imaging: comparison of three different calculation methods in transplanted kidneys. Acta Radiol 54:1210–1217
Chandarana H, Kang SK, Wong S et al (2012) Diffusion-weighted intravoxel incoherent motion imaging of renal tumors with histopathologic correlation. Invest Radiol 47:688–696
Rosenkrantz AB, Niver BE, Fitzgerald EF, Babb JS, Chandarana H, Melamed J (2010) Utility of the apparent diffusion coefficient for distinguishing clear cell renal cell carcinoma of low and high nuclear grade. AJR Am J Roentgenol 195:W344–W351
Sandrasegaran K, Sundaram CP, Ramaswamy R et al (2010) Usefulness of diffusion-weighted imaging in the evaluation of renal masses. AJR Am J Roentgenol 194:438–445
Tanaka H, Yoshida S, Fujii Y et al (2011) Diffusion-weighted magnetic resonance imaging in the differentiation of angiomyolipoma with minimal fat from clear cell renal cell carcinoma. Int J Urol 18:727–730
Taouli B, Thakur RK, Mannelli L et al (2009) Renal lesions: characterization with diffusion-weighted imaging versus contrast-enhanced MR imaging. Radiology 251:398–407
Wang H, Cheng L, Zhang X et al (2010) Renal cell carcinoma: diffusion-weighted MR imaging for subtype differentiation at 3.0 T. Radiology 257:135–143
Zhang J, Tehrani YM, Wang L, Ishill NM, Schwartz LH, Hricak H (2008) Renal masses: characterization with diffusion-weighted MR imaging – a preliminary experience. Radiology 247:458–464
Sevcenco S, Heinz-Peer G, Ponhold L et al (2014) Utility and limitations of 3-Tesla diffusion-weighted magnetic resonance imaging for differentiation of renal tumors. Eur J Radiol 83:909–913
Lassel EA, Rao R, Schwenke C, Schoenberg SO, Michaely HJ (2014) Diffusion-weighted imaging of focal renal lesions: a meta-analysis. Eur Radiol 24:241–249
Goyal A, Sharma R, Bhalla AS, Gamanagatti S, Seth A (2013) Diffusion-weighted MRI in inflammatory renal lesions: all that glitters is not RCC! Eur Radiol 23:272–279
Henninger B, Reichert M, Haneder S, Schoenberg SO, Michaely HJ (2013) Value of diffusion-weighted MR imaging for the detection of nephritis. Sci World J 2013:1–8
Thoeny HC, De Keyzer F, Oyen RH, Peeters RR (2005) Diffusion-weighted MR imaging of kidneys in healthy volunteers and patients with parenchymal diseases: initial experience. Radiology 235:911–917
Togao O, Doi S, Kuro-o M, Masaki T, Yorioka N, Takahashi M (2010) Assessment of renal fibrosis with diffusion-weighted MR imaging: study with murine model of unilateral ureteral obstruction. Radiology 255:772–780
Carbone SF, Gaggioli E, Ricci V, Mazzei F, Mazzei MA, Volterrani L (2007) Diffusion-weighted magnetic resonance imaging in the evaluation of renal function: a preliminary study. Radiol Med (Torino) 112:1201–1210
Namimoto T, Yamashita Y, Mitsuzaki K, Nakayama Y, Tang Y, Takahashi M (1999) Measurement of the apparent diffusion coefficient in diffuse renal disease by diffusion-weighted echo-planar MR imaging. J Magn Reson Imaging 9:832–837
Park SY, Jung SE, Jeong WK, Kim CK, Park BK, Choi D (2015) Renal function impairment in liver cirrhosis: preliminary results with diffusion-weighted imaging at 3 T. AJR Am J Roentgenol 204:1024–1030
Yang L, Li XM, Zhao S, Hu YJ, Liu RB (2015) Diffusion-weighted imaging of the kidneys and its relationship with residual renal function in continuous ambulatory peritoneal dialysis patients. AJR Am J Roentgenol 204:1008–1012
Blondin D, Lanzman RS, Klasen J et al (2011) Diffusion-attenuated MRI signal of renal allografts: comparison of two different statistical models. AJR Am J Roentgenol 196:W701–W705
Blondin D, Lanzman RS, Mathys C et al (2009) Functional MRI of transplanted kidneys using diffusion-weighted imaging. Rofo 181:1162–1167
Eisenberger U, Binser T, Thoeny HC, Boesch C, Frey FJ, Vermathen P (2014) Living renal allograft transplantation: diffusion-weighted MR imaging in longitudinal follow-up of the donated and the remaining kidney. Radiology 270:800–808
Eisenberger U, Thoeny HC, Binser T et al (2010) Evaluation of renal allograft function early after transplantation with diffusion-weighted MR imaging. Eur Radiol 20:1374–1383
Notohamiprodjo M, Dietrich O, Horger W et al (2010) Diffusion tensor imaging (DTI) of the kidney at 3 tesla-feasibility, protocol evaluation and comparison to 1.5 Tesla. Invest Radiol 45:245–254
Heusch P, Wittsack HJ, Kropil P et al (2013) Impact of blood flow on diffusion coefficients of the human kidney: a time-resolved ECG-triggered diffusion-tensor imaging (DTI) study at 3T. J Magn Reson Imaging 37:233–236
Notohamiprodjo M, Chandarana H, Mikheev A et al (2015) Combined intravoxel incoherent motion and diffusion tensor imaging of renal diffusion and flow anisotropy. Magn Reson Med 73:1526–1532
Gaudiano C, Clementi V, Busato F et al (2013) Diffusion tensor imaging and tractography of the kidneys: assessment of chronic parenchymal diseases. Eur Radiol 23:1678–1685
Liu Z, Xu Y, Zhang J et al (2015) Chronic kidney disease: pathological and functional assessment with diffusion tensor imaging at 3T MR. Eur Radiol 25:652–660
Hueper K, Hartung D, Gutberlet M et al (2012) Magnetic resonance diffusion tensor imaging for evaluation of histopathological changes in a rat model of diabetic nephropathy. Invest Radiol 47:430–437
Lu L, Sedor JR, Gulani V et al (2011) Use of diffusion tensor MRI to identify early changes in diabetic nephropathy. Am J Nephrol 34:476–482
Hueper K, Gutberlet M, Rodt T et al (2011) Diffusion tensor imaging and tractography for assessment of renal allograft dysfunction-initial results. Eur Radiol 21(11):2427–2433
Lanzman RS, Ljimani A, Pentang G et al (2013) Kidney transplant: functional assessment with diffusion-tensor MR imaging at 3T. Radiology 266:218–225
Logothetis NK, Pauls J, Augath M, Trinath T, Oeltermann A (2001) Neurophysiological investigation of the basis of the fMRI signal. Nature 412:150–157
Prasad PV, Edelman RR, Epstein FH (1996) Noninvasive evaluation of intrarenal oxygenation with BOLD MRI. Circulation 94:3271–3275
dos Santos EA, Li LP, Ji L, Prasad PV (2007) Early changes with diabetes in renal medullary hemodynamics as evaluated by fiberoptic probes and BOLD magnetic resonance imaging. Invest Radiol 42:157–162
Khatir DS, Pedersen M, Jespersen B, Buus NH (2014) Reproducibility of MRI renal artery blood flow and BOLD measurements in patients with chronic kidney disease and healthy controls. J Magn Reson Imaging 40:1091–1098
Li LP, Storey P, Pierchala L, Li W, Polzin J, Prasad P (2004) Evaluation of the reproducibility of intrarenal R2* and DeltaR2* measurements following administration of furosemide and during waterload. J Magn Reson Imaging 19:610–616
Simon-Zoula SC, Hofmann L, Giger A et al (2006) Non-invasive monitoring of renal oxygenation using BOLD-MRI: a reproducibility study. NMR Biomed 19:84–89
Thoeny HC, Zumstein D, Simon-Zoula S et al (2006) Functional evaluation of transplanted kidneys with diffusion-weighted and BOLD MR imaging: initial experience. Radiology 241:812–821
Djamali A, Sadowski EA, Muehrer RJ et al (2007) BOLD-MRI assessment of intrarenal oxygenation and oxidative stress in patients with chronic kidney allograft dysfunction. Am J Physiol Renal Physiol 292:F513–F522
Han F, Xiao W, Xu Y et al (2008) The significance of BOLD MRI in differentiation between renal transplant rejection and acute tubular necrosis. Nephrol Dial Transplant 23:2666–2672
Mathys C, Blondin D, Wittsack HJ et al (2011) T2’ imaging of native kidneys and renal allografts - a feasibility study. Rofo 183:112–119
Sadowski EA, Fain SB, Alford SK et al (2005) Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging: initial experience. Radiology 236:911–919
Sadowski EA, Djamali A, Wentland AL et al (2010) Blood oxygen level-dependent and perfusion magnetic resonance imaging: detecting differences in oxygen bioavailability and blood flow in transplanted kidneys. Magn Reson Imaging 28:56–64
Tumkur SM, Vu AT, Li LP, Pierchala L, Prasad PV (2006) Evaluation of intra-renal oxygenation during water diuresis: a time-resolved study using BOLD MRI. Kidney Int 70:139–143
Epstein FH, Prasad P (2000) Effects of furosemide on medullary oxygenation in younger and older subjects. Kidney Int 57:2080–2083
Prasad PV, Epstein FH (1999) Changes in renal medullary pO2 during water diuresis as evaluated by blood oxygenation level-dependent magnetic resonance imaging: effects of aging and cyclooxygenase inhibition. Kidney Int 55:294–298
Epstein FH, Veves A, Prasad PV (2002) Effect of diabetes on renal medullary oxygenation during water diuresis. Diabetes Care 25:575–578
Ries M, Basseau F, Tyndal B et al (2003) Renal diffusion and BOLD MRI in experimental diabetic nephropathy. Blood oxygen level-dependent. J Magn Reson Imaging 17:104–113
Hofmann L, Simon-Zoula S, Nowak A et al (2006) BOLD-MRI for the assessment of renal oxygenation in humans: acute effect of nephrotoxic xenobiotics. Kidney Int 70:144–150
Thoeny HC, Kessler TM, Simon-Zoula S et al (2008) Renal oxygenation changes during acute unilateral ureteral obstruction: assessment with blood oxygen level-dependent mr imaging – initial experience. Radiology 247:754–761
Inoue T, Kozawa E, Okada H et al (2011) Noninvasive evaluation of kidney hypoxia and fibrosis using magnetic resonance imaging. J Am Soc Nephrol 22:1429–1434
Michaely HJ, Metzger L, Haneder S, Hansmann J, Schoenberg SO, Attenberger UI (2012) Renal BOLD-MRI does not reflect renal function in chronic kidney disease. Kidney Int 81:684–689
Dagher AP, Aletras A, Choyke P, Balaban RS (2000) Imaging of urea using chemical exchange-dependent saturation transfer at 1.5T. J Magn Reson Imaging 12:745–748
Longo DL, Busato A, Lanzardo S, Antico F, Aime S (2013) Imaging the pH evolution of an acute kidney injury model by means of iopamidol, a MRI-CEST pH-responsive contrast agent. Magn Reson Med 70:859–864
Muller-Lutz A, Khalil N, Schmitt B et al (2014) Pilot study of Iopamidol-based quantitative pH imaging on a clinical 3T MR scanner. MAGMA 27:477–485
Haneder S, Konstandin S, Morelli JN, Schad LR, Schoenberg SO, Michaely HJ (2013) Assessment of the renal corticomedullary (23)Na gradient using isotropic data sets. Acad Radiol 20:407–413
Moon CH, Furlan A, Kim JH, Zhao T, Shapiro R, Bae KT (2014) Quantitative sodium MR imaging of native versus transplanted kidneys using a dual-tuned proton/sodium (1H/23Na) coil: initial experience. Eur Radiol 24:1320–1326
Cornelis F, Tricaud E, Lasserre AS et al (2014) Routinely performed multiparametric magnetic resonance imaging helps to differentiate common subtypes of renal tumours. Eur Radiol 24:1068–1080
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R.S. Lanzman, M. Notohamiprodjo und H.J. Wittsack geben an, dass kein Interessenkonflikt besteht.
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Lanzman, R.S., Notohamiprodjo, M. & Wittsack, H. Funktionelle Magnetresonanztomographie der Nieren. Radiologe 55, 1077–1087 (2015). https://doi.org/10.1007/s00117-015-0044-z
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DOI: https://doi.org/10.1007/s00117-015-0044-z
Schlüsselwörter
- Funktionelle Nieren-MRT
- Perfusionsbildgebung
- Diffusion-weighted imaging (DWI)
- Diffusion-tensor imaging (DTI)
- Arterial Spin Labeling
- BOLD Bildgebung