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Methodische Probleme klinischer funktioneller MRT-Untersuchungen

Methodological problems with clinical functional MRI investigations

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Zusammenfassung

Die klinische funktionelle Magnetresonanztomographie (fMRT) hat als individuelles Untersuchungsverfahren v. a. in der präoperativen Diagnostik bei Epilepsie- und Tumorpatienten einen zunehmenden Stellenwert, da sie hier zu einer klinischen Entscheidung beitragen kann. Die rasche Entwicklung der fMRT-Technologie eröffnet dabei kontinuierlich neue diagnostische Möglichkeiten, erfordert aber auch einen kritischen Umgang mit den zahlreichen methodischen Problemen dieses komplexen Verfahrens. Dieser Artikel beschreibt patientenrelevante Probleme und Lösungsmöglichkeiten von der Untersuchung bis zur Erstellung des individuellen fMRT-Befundes.

Abstract

During presurgical diagnostics clinical functional magnetic resonance imaging is increasingly being performed to improve the management of epilepsy and tumor patients. Rapid technical developments in fMRI technology continuously further new diagnostic applications. Safe clinical application requires a profound and critical handling of the various methodological problems inherent with this complex technique. This article reviews relevant problems and solutions for patient investigations up to the preparation of an individual clinical fMRI report.

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Literatur

  1. Bandettini PA (2009) What’s new in neuroimaging methods? Ann N Y Acad Sci 1156:260–293

    Article  PubMed  Google Scholar 

  2. Beisteiner R, Drabeck K, Foki T et al (2008) Does clinical memory fMRI provide a comprehensive map of medial temporal lobe structures? Exp Neurol 213:154–162

    Article  PubMed  Google Scholar 

  3. Beisteiner R (2009) Funktionelle Magnetresonanztomographie. In: Lehrner J, Pusswald G, Fertl E et al (Hrsg) Klinische Neuropsychologie. 2. Aufl. Springer, Berlin Heidelberg New York, in Druck

  4. Beisteiner R, Klinger N, Höllinger I et al (2010) How much are clinical fMRI reports influenced by standard postprocessing methods? An investigation of normalization and region of interest effects in the medial temporal lobe. Hum Brain Mapp, in press

  5. Brett M, Johnsrude IS, Owen AM (2002) The problem of functional localization in the human brain. Nat Rev Neurosci 3:243–249

    Article  CAS  PubMed  Google Scholar 

  6. Devlin JT, Poldrack RA (2007) In praise of tedious anatomy. Neuroimage 37:1033–1041

    Article  PubMed  Google Scholar 

  7. Devor A, Tian P, Nishimura N et al (2007) Suppressed neuronal activity and concurrent arteriolar vasoconstriction may explain negative blood oxygenation level-dependent signal. J Neurosci 27:4452–4459

    Article  CAS  PubMed  Google Scholar 

  8. Eickhoff SB, Paus T, Caspers S et al (2007) Assignment of functional activations to probabilistic cytoarchitectonic areas revisited. Neuroimage 36:511–521

    Article  PubMed  Google Scholar 

  9. Foki T, Gartus A, Geissler A, Beisteiner R (2008) Probing overtly spoken language at sentential level – a comprehensive high-field BOLD-fMRI protocol reflecting everyday language demands. Neuroimage 39:1613–1624

    Article  PubMed  Google Scholar 

  10. Gartus A, Foki T, Geissler A, Beisteiner R (2009) Improvement of clinical language localization with an overt semantic and syntactic language functional MR imaging paradigm. AJNR Am J Neuroradiol 30(10):1977–1985

    Article  CAS  PubMed  Google Scholar 

  11. Gartus A, Geissler A, Foki T et al (2007) Comparison of fMRI coregistration results between human experts and software solutions in patients and healthy subjects. Eur Radiol 17:1634–1643

    Article  PubMed  Google Scholar 

  12. Geissler A, Gartus A, Foki T et al (2007) Contrast-to-noise ratio (CNR) as a quality parameter in fMRI. J Magn Reson Imaging 25:1263–1270

    Article  PubMed  Google Scholar 

  13. Geissler A, Lanzenberger R, Barth M et al (2005) Influence of fMRI smoothing procedures on replicability of fine scale motor localization. Neuroimage 24:323–331

    Article  PubMed  Google Scholar 

  14. Haller S, Bartsch AJ (2009) Pitfalls in fMRI. Eur Radiol 19(11):2689–2706

    Article  PubMed  Google Scholar 

  15. Hennig J, Zhong K, Speck O (2007) MR encephalography: fast multi-channel monitoring of brain physiology with magnetic resonance. Neuroimage 34:212–219

    Article  PubMed  Google Scholar 

  16. Huang J, Carr TH, Cao Y (2002) Comparing cortical activations for silent and overt speech using event-related fMRI. Hum Brain Mapp 15:39–53

    Article  PubMed  Google Scholar 

  17. Klein A, Andersson J, Ardekani BA et al (2009) Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration. Neuroimage 46:786–802

    Article  PubMed  Google Scholar 

  18. Koopmans PJ, Manniesing R, Niessen WJ et al (2008) MR venography of the human brain using susceptibility weighted imaging at very high field strength. MAGMA 21:149–158

    Article  PubMed  Google Scholar 

  19. Krings T, Reinges MH, Erberich S et al (2001) Functional MRI for presurgical planning: problems, artefacts, and solution strategies. J Neurol Neurosurg Psychiatry 70:749–760

    Article  CAS  PubMed  Google Scholar 

  20. Logothetis NK (2008) What we can do and what we cannot do with fMRI. Nature 453:869–878

    Article  CAS  PubMed  Google Scholar 

  21. Matthews PM, Honey GD, Bullmore ET (2006) Applications of fMRI in translational medicine and clinical practice. Nat Rev Neurosci 7:732–744

    Article  CAS  PubMed  Google Scholar 

  22. Mitsis GD, Iannetti GD, Smart TS et al (2008) Regions of interest analysis in pharmacological fMRI: how do the definition criteria influence the inferred result? Neuroimage 40:121–132

    Article  PubMed  Google Scholar 

  23. Nowak DA, Grefkes C, Dafotakis M et al (2008) Effects of low-frequency repetitive transcranial magnetic stimulation of the contralesional primary motor cortex on movement kinematics and neural activity in subcortical stroke. Arch Neurol 65:741–747

    Article  PubMed  Google Scholar 

  24. Roessler K, Donat M, Lanzenberger R et al (2005) Evaluation of preoperative high magnetic field motor functional-MRI (3 tesla) in glioma patients by navigated electrocortical stimulation and postoperative outcome. J Neurol Neurosurg Psychiatry 76:1152–1157

    Article  CAS  PubMed  Google Scholar 

  25. Shmuel A, Yacoub E, Chaimow D et al (2007) Spatio-temporal point-spread function of fMRI signal in human gray matter at 7 tesla. Neuroimage 35:539–552

    Article  PubMed  Google Scholar 

  26. Shmuel A, Yacoub E, Pfeuffer J et al (2002) Sustained negative BOLD, blood flow and oxygen consumption response and its coupling to the positive response in the human brain. Neuron 36:1195–1210

    Article  CAS  PubMed  Google Scholar 

  27. Sutton BP, Ouyang C, Karampinos DC, Miller GA (2009) Current trends and challenges in MRI acquisitions to investigate brain function. Int J Psychophysiol 73:33–42

    Article  PubMed  Google Scholar 

  28. Tamás Kincses Z, Johansen-Berg H, Tomassini V et al (2008) Model-free characterization of brain functional networks for motor sequence learning using fMRI. Neuroimage 15:1950–1958

    Google Scholar 

  29. Tzourio-Mazoyer N, Landeau B, Papathanassiou D et al (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15:273–289

    Article  CAS  PubMed  Google Scholar 

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Danksagung

Die Autoren danken nachfolgenden Mitgliedern der AG klinische fMRT Wien für ihre Beiträge zu den diesem Artikel zugrunde liegenden Messdaten: Alexander Geißler, Susanne Gruber, Ilse Höllinger, Nicolaus Klinger, Jakob Rath.

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Correspondence to R. Beisteiner MD, MA.

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Foki, T., Beisteiner, R. Methodische Probleme klinischer funktioneller MRT-Untersuchungen. Radiologe 50, 104–109 (2010). https://doi.org/10.1007/s00117-009-1896-x

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  • DOI: https://doi.org/10.1007/s00117-009-1896-x

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