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Simulation des Blutflusses in der abdominellen Aorta

Die numerische Simulation des Blutflusses in abdominellen Aortenaneurysmen vor und nach Intervention

Simulation of blood flow within the abdominal aorta

Computational fluid dynamics in abdominal aortic aneurysms before and after interventions

  • Leitthema: Aorta
  • Published:
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Zusammenfassung

Das Ziel der numerischen Simulation des Blutflusses in der Aorta ist, die Mechanik der Entstehung von Aortenaneurysmen im Hinblick auf das Rupturrisiko zu untersuchen und die Wirkungen interventioneller Maßnahmen zu beschreiben.

Die Grundlage der numerischen Simulation sind virtuelle Modelle von Gefäßen und die physikalischen Eigenschaften der Gefäßbestandteile, des Blutes und der Strömung. Basierend auf diesen Angaben werden mit Hilfe numerischer Methoden die strömungsmechanischen Probleme des Blutflusses näherungsweise gelöst. Die Ergebnisse können dann quantitativ und qualitativ dargestellt werden.

Die Ergebnisse der numerischen Flusssimulation zeigen, dass in abdominellen Aortenaneurysmen die Höhe des Wanddrucks, der von entscheidender Bedeutung für das Rupturrisiko ist, von verschiedenen Faktoren, wie z. B. der Lage des Wandthrombus, abhängt.

In Modellen mit Stentgrafts wurden mit Hilfe der numerischen Simulation Faktoren, welche die Stentgraftmigration beeinflussen, untersucht.

Obwohl die numerische Simulation des Blutflusses noch einige Limitationen aufweist, zeigen aktuelle Studien, dass die Methode das Potenzial hat, um in Zukunft eine dedizierte Beurteilung des Rupturrisikos von Aortenaneurysmen vorzunehmen.

Abstract

The goal of numeric analysis of aortic blood flow is to evaluate the mechanisms leading to an aortic aneurysm with regard to the risk of a rupture and to describe the effect of interventional therapy. Numeric analysis is based on virtual models of vascular structures and the physical characteristics of the vessel wall, of blood as fluidum, and the blood flow. Using this information, numeric analysis solves the appropriate equations. The results can be displayed quantitatively and qualitatively.

The results of numeric flow simulation show that in abdominal aortic aneurysms the wall pressure, which is of vital importance for the risk of rupture, depends on several factors, one being the location of the intraluminal thrombus.

In models of aneurysms after stent grafting, numeric analysis can be used to evaluate factors leading to stent migration.

Although numeric analysis of aortic blood flow still has several limitations, recent studies have shown that this method has the potential for improved estimation of the rupture risk of aortic aneurysms in the near future.

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Authors and Affiliations

  1. Institut für Diagnostische Radiologie, Universitätsspital Zürich, Rämistrasse 100 , CH-8091, Zürich, Schweiz

    T. Frauenfelder, H. Alkadhi , B. Marincek & T. Schertler

  2. Labor für Computerwissenschaften und Engineering, ETH Zürich, Zürich, Schweiz

    E. Boutsianis

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  1. T. Frauenfelder
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  2. E. Boutsianis
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  3. H. Alkadhi
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  4. B. Marincek
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Correspondence to T. Frauenfelder.

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Frauenfelder, T., Boutsianis, E., Alkadhi , H. et al. Simulation des Blutflusses in der abdominellen Aorta. Radiologe 47, 1021–1028 (2007). https://doi.org/10.1007/s00117-007-1576-7

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  • DOI: https://doi.org/10.1007/s00117-007-1576-7

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