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Histone modification in podocyte injury of diabetic nephropathy

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Abstract

Diabetic nephropathy (DN), an important complication of diabetic microvascular disease, is one of the leading causes of end-stage renal disease (ESRD), which brings heavy burdens to the whole society. Podocytes are terminally differentiated glomerular cells, which act as a pivotal component of glomerular filtration barrier. When podocytes are injured, glomerular filtration barrier is damaged, and proteinuria would occur. Dysfunction of podocytes contributes to DN. And degrees of podocyte injury influence prognosis of DN. Growing evidences have shown that epigenetics does a lot in the evolvement of podocyte injury. Epigenetics includes DNA methylation, histone modification, and non-coding RNA. Among them, histone modification plays an indelible role. Histone modification includes histone methylation, histone acetylation, and other modifications such as histone phosphorylation, histone ubiquitination, histone ADP-ribosylation, histone crotonylation, and histone β-hydroxybutyrylation. It can affect chromatin structure and regulate gene transcription to exert its function. This review is to summarize documents about pathogenesis of podocyte injury, most importantly, histone modification of podocyte injury in DN recently to provide new ideas for further molecular research, diagnosis, and treatment.

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Acknowledgements

The authors would like to thank the anonymous reviewers for their helpful remarks. They also thank the associate editor and the reviewers for their useful feedback that improved this paper.

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Authors and Affiliations

  1. Department of Nephrology, Shandong Provincial Hospital, Shandong University, Jinan, 250012, Shandong, China

    Simeng Wang, Xinyu Zhang, Qinglian Wang & Rong Wang

  2. Department of Nephrology, Shandong Provincial Hospital, Shandong First Medical University, No. 324 Jingwu Street, Jinan, 250021, Shandong, China

    Qinglian Wang & Rong Wang

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  1. Simeng Wang
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All authors contributed to the review conception and design. Literature reading, associated manuscript collection, and analysis were performed by Simeng Wang, Xinyu Zhang, and Qinglian Wang. The modification of this review was performed by Simeng Wang, Qinglian Wang, and Rong Wang. The first draft of the manuscript was written by Simeng Wang, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Wang, S., Zhang, X., Wang, Q. et al. Histone modification in podocyte injury of diabetic nephropathy. J Mol Med 100, 1373–1386 (2022). https://doi.org/10.1007/s00109-022-02247-7

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