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Mitophagy and heart failure

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Abstract

Cardiac mitochondria are responsible for generating energy in the form of ATP through oxidative phosphorylation and are crucial for cardiac function. Mitochondrial dysfunction is a major contributor to loss of myocytes and development of heart failure. Myocytes have quality control mechanisms in place to ensure a network of functional mitochondria. Damaged mitochondria are degraded by a process called mitochondrial autophagy, or mitophagy, where the organelle is engulfed by an autophagosome and subsequently delivered to a lysosome for degradation. Evidence suggests that mitophagy is important for cellular homeostasis, and reduced mitophagy leads to inadequate removal of dysfunctional mitochondria. In this review, we discuss the regulation of mitophagy and the emerging evidence of the cardioprotective role of mitophagy. We also address the prospect of therapeutically targeting mitophagy to treat patients with cardiovascular disease.

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Acknowledgments

Å.B. Gustafsson is supported by an AHA Established Investigator Award and National Institutes of Health grants R01HL087023, R01HL101217, and P01HL085577. S.E. Shires is supported by T32GM007752.

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  1. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, 9500 Gilman Drive MC 0758, La Jolla, CA, 92093-0758, USA

    Sarah E. Shires & Åsa B. Gustafsson

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Correspondence to Åsa B. Gustafsson.

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Shires, S.E., Gustafsson, Å.B. Mitophagy and heart failure. J Mol Med 93, 253–262 (2015). https://doi.org/10.1007/s00109-015-1254-6

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  • DOI: https://doi.org/10.1007/s00109-015-1254-6

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