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Bmi1 in development and tumorigenesis of the central nervous system

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Abstract

The role of the Polycomb group gene Bmi1 in proliferation control of lymphoid and neuronal progenitors as well as in self-renewal of haematopoietic and neural stem cells has been recently demonstrated. Here we review these recent findings with particular regard to their implications for central nervous system development and tumorigenesis.

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Acknowledgements

O.S. is supported by a grant of the Sassella-Stiftung to S.M. The work in Dr. Marino’s laboratory is supported by grants of the Swiss Cancer League, Swiss National Science Foundation and from the University of Zürich (Forschungskredit).

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Authors and Affiliations

  1. Institute of Clinical Pathology, University Hospital, Schmelzbergstrasse 12, 8091, Zürich, Switzerland

    Olga Shakhova, Carly Leung & Silvia Marino

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  1. Olga Shakhova
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  2. Carly Leung
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  3. Silvia Marino
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Correspondence to Silvia Marino.

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Shakhova, O., Leung, C. & Marino, S. Bmi1 in development and tumorigenesis of the central nervous system. J Mol Med 83, 596–600 (2005). https://doi.org/10.1007/s00109-005-0682-0

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  • DOI: https://doi.org/10.1007/s00109-005-0682-0

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