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Jüngste Entwicklungen in der Kopf-Hals-Immunologie

Grundlage für neue Therapiestrategien?

Recent developments in head and neck immunology

A basis for novel therapeutic strategies?

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Zusammenfassung

Immunologische Vorgänge spielen eine wesentliche Rolle bei der Pathogenese von Erkrankungen des Kopf-Hals-Bereichs. In diesem Zusammenhang ist nicht nur an Allergien oder an Infektionen im Bereich der Mandeln, der Nasennebenhöhlen und des Ohres zu denken, auch Entstehung, Wachstum und Metastasierung von malignen Tumoren des Kopf-Hals-Bereichs werden maßgeblich vom Immunsystem beeinflusst. Die Rekrutierung von weißen Blutkörperchen zum Ort der Schädigung oder Infektion stellt dabei ein zentrales Ereignis dar. In diesem Beitrag wird dem Hals-Nasen-Ohren-Arzt eine kompakte Übersicht über neue Erkenntnisse in diesem sich rasch fortentwickelnden Bereich der HNO-Heilkunde gegeben. Dieses Wissen könnte in den nächsten Jahren die Grundlage für vielversprechende Therapiestrategien zu bislang nur unzureichend behandelbaren Erkrankungen im HNO-Fachgebiet bilden.

Abstract

Immunological processes play a key role in the pathogenesis of head and neck pathologies. Besides allergies or infections of the tonsils, the paranasal sinuses, and the ear, initiation, progression, and metastasis of malignant tumors are particularly dependent on the immune system. The recruitment of white blood cells to the site of injury or infection is a critical event in the pathogenesis of these diseases. This article will provide a compact overview about recent developments in this rapidly growing field in otorhinolaryngology which might establish the basis for promising therapeutic strategies for previously insufficiently treatable disorders of the head and neck.

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Authors and Affiliations

  1. Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Klinikum der Universität München, Marchioninistr. 15, 81377, München, Deutschland

    C. A. Reichel

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  1. C. A. Reichel
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Correspondence to C. A. Reichel.

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C.A. Reichel gibt an, dass kein Interessenkonflikt besteht.

Alle nationalen Richtlinien zur Haltung und zum Umgang mit Labortieren wurden eingehalten und die notwendigen Zustimmungen der zuständigen Behörden liegen vor.

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PD Dr. med. Christoph A. Reichel, München, hat auf der 89. Jahresversammlung der Deutschen Gesellschaft für Hals-Nasen-Ohren-Heilkunde, Kopf- und Hals-Chirurgie (DGHNO KHC) in Lübeck den Forschungspreis 2018 der Arbeitsgemeinschaft (AG) Onkologie für seinen Vortrag „The NLRP3 inflammasome regulates neutrophil trafficking to HNSCC“ erhalten.

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Reichel, C.A. Jüngste Entwicklungen in der Kopf-Hals-Immunologie. HNO 67, 258–264 (2019). https://doi.org/10.1007/s00106-019-0639-1

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  • DOI: https://doi.org/10.1007/s00106-019-0639-1

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