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Häufigste benigne Gefäß‑, Muskel- und Fettgewebstumoren der Haut und ihre Therapie

The most common benign cutaneous neoplasms of vascular, muscular, and adipose tissue and their treatment

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Zusammenfassung

Benigne kutane Gefäßtumoren sowie Hauttumoren, die aus Muskel- oder Fettgewebe hervorgehen, sind selten. Ihre Definition und Klassifikation ist noch umstritten. Histopathologische und immunhistochemische Untersuchungen tragen zusammen mit den neuen Gentests wesentlich zur korrekten Beschreibung der verschiedenen benignen Tumoren kutanen Ursprungs bei. Die Benignität der Läsion abzuklären ist von grundlegender Bedeutung für die Prognose und das therapeutische Vorgehen. In den meisten Fällen stellt die schlichte chirurgische Entfernung die Therapie der Wahl dar. Dermatologen sollten die bestehende Klassifikation der häufigsten benignen Gefäß‑, Muskel- und Fettgewebstumoren der Haut kennen und die gegenwärtig für eine genaue Diagnose eingesetzten Verfahren empfehlen können. Die Sicherung der Benignität einer Läsion und ein gutes operatives Ergebnis sind für den Patienten essenziell.

Abstract

Benign cutaneous vascular and cutaneous neoplasms arising from muscle or adipose tissue are rare. Their definition and classification are still controversially discussed. Histopathological and immunohistochemical studies, together with the new genetic tests, contribute significantly to the correct description of the various benign neoplasms of cutaneous origin. Clarifying whether a lesion is benign is fundamental for prognosis and therapeutic management. In most cases, surgical excision is the treatment of choice. Dermatologists should be familiar with the classifications of the most common benign cutaneous neoplasms of vascular, muscular, and adipose tissue and be able to recommend the procedures currently used for an accurate diagnosis. Ensuring that a lesion is benign and a good surgical outcome are essential for the patient.

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Literatur

  1. Becker JC, Atzwanger BL, Ugurel S et al (2011) Section 23: tumors and hyperplasias of the dermis and subcutaneous fat. In: Wolff K, Goldsmith L, Katz S, Gilchrest B, Paller AS, Leffell D (Hrsg) Fitzpatrick’s dermatology in general medicine, 8. Aufl. McGraw-Hill, New York, S 1456–1480

    Google Scholar 

  2. Calonje E (2010) Chapter 56: soft-tissue tumours and tumour-like conditions. In: Rook A, In Burns T (Hrsg) Rook’s textbook of dermatology. Wiley-Blackwell, Chichester, West Sussex, UK, S 25–56

    Google Scholar 

  3. Burgdorf WHC, Plewig G, Wolff HH, Landthaler M, Braun-Falco O (Hrsg) (2008) Braun-Falco´s Dermatology. Springer, Heidelberg, S 1442–1468

  4. Calonje E, Brenn T (2015) Chapter 33 vascular tumors: tumors and tumorlike conditions of blood vessels and Lymphatics. In: Elder D, Elenitsas R, Rosenbach M, Murphy G, Rubin A, Xu X (Hrsg) Lever’s histopathology of the skin, 11. Aufl. Wolters Kluwer, Dordrecht, S 2643–2793

    Google Scholar 

  5. Moore JB, Ragsdale B (2015) Chapter 43 tumors with fatty, muscular, osseous, and/or cartilaginous differentiation. In: Elder D, Elenitsas R, Rosenbach M, Murphy G, Rubin A, Xu X (Hrsg) Lever’s histopathology of the skin, 11. Aufl. Wolters Kluwer, Dordrecht, S 2794–2900

    Google Scholar 

  6. Saurat JH (2004) Lipsker. [Maladies dex vaisseaux]. In: Saurat JH, Grosshans E, Laugier P, Lachapelle JM (Hrsg) Dermatologie et infections sexuellement transmissibles, 4. Aufl. Elsevier, Masson, S 693–708

    Google Scholar 

  7. International Society for the Study of Vascular Anomalies ISSVA classification of vascular anomalies 2018.. Zugegriffen: 1. Nov. 2021

  8. Mocellin S (2021) Congenital hemangioma. In: Soft tissue tumors. Springer, Cham, S 181–183

    Chapter  Google Scholar 

  9. Lee PW, Frieden IJ, Streicher JL, McCalmont T, Haggstrom AN (2014) Characteristics of noninvoluting congenital hemangioma: a retrospective review. J Am Acad Dermatol 70(5):899–903

    Article  Google Scholar 

  10. Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HP, Bischoff J, Greene AK (2016) Somatic activating mutations in GNAQ and GNA11 are associated with congenital hemangioma. Am J Hum Genet 98(4):789–795

    Article  CAS  Google Scholar 

  11. Tiemann L, Hein S (2020) Infantile hemangioma: a review of current pharmacotherapy treatment and practice pearls. J Pediatr Pharmacol Ther 25(7):586–599. https://doi.org/10.5863/1551-6776-25.7.586

    Article  PubMed  PubMed Central  Google Scholar 

  12. Satterfield KR, Chambers CB (2019) Current treatment and management of infantile hemangiomas. Surv Ophthalmol 64(5):608–618. https://doi.org/10.1016/j.survophthal.2019.02.005

    Article  PubMed  Google Scholar 

  13. Mathes EF, Frieden IJ (2019) Chapter 126: vascular tumors. In: Orringer JS, McMichael AJ, Margolis DJ, Enk AH, Bruckner AL, Amagai M, Kang S (Hrsg) Fitzpatrick dermatology, 9. Aufl. McGraw-Hill, New York, S 2042–2045

    Google Scholar 

  14. Smith CJF, Friedlander SF, Guma M, Kavanaugh A, Chambers CD (2017) Infantile hemangiomas: an updated review on risk factors, pathogenesis, and treatment. Birth Defects Res 109(11):809–815. https://doi.org/10.1002/bdr2.1023

    Article  CAS  PubMed  Google Scholar 

  15. Iacobas I, Phung TL, Adams DM et al (2018) Guidance document for hepatic hemangioma (infantile and congenital) evaluation and monitoring. J Pediatr 203:294

    Article  Google Scholar 

  16. Kerns ML, Chien AL, Kang S (2019) Chapter 106: skin aging. In: Orringer JS, McMichael AJ, Margolis DJ, Enk AH, Bruckner AL, Amagai M, Kang S (Hrsg) Fitzpatrick dermatology, 9. Aufl. McGraw-Hill, New York, S 1785–1788

    Google Scholar 

  17. Higgins JC, Maher MH, Douglas MS (2015) Diagnosing common benign skin tumors. Am Fam Physician 92(7):601–607

    PubMed  Google Scholar 

  18. Nazer RI, Bashihab RH, Al-Madani WH, Omair AA, AlJasser MI (2020) Cherry angioma: a case-control study. J Family Community Med 27(2):109–113. https://doi.org/10.4103/jfcm.JFCM_293_19

    Article  PubMed  PubMed Central  Google Scholar 

  19. Mehta AB, Orteu CH. (2019) Fabry disease. In: Orringer JS, McMichael AJ, Margolis DJ, Enk AH, Bruckner AL, Amagai M, Kang S (Hrsg) Fitzpatrick dermatology, 9. Aufl. McGraw-Hill, New York, S 2295

    Google Scholar 

  20. Qadeer HA, Singal A, Patel BC (2021) Cherry hemangioma. In: StatPearls, Bd. 33085354. StatPearls Publishing, Treasure Island

    Google Scholar 

  21. Feito-Rodríguez M, Sánchez-Orta A, De Lucas R, López-Gutiérrez JC, Ruiz-Bravo E, Baselga E, Victoria AM, Hernández-Martín A, Campos-Domínguez M, Berenguer Fröhner B, Garnacho-Saucedo G (2018) Congenital tufted angioma: a multicenter retrospective study of 30 cases. Pediatr Dermatol 35(6):808–816

    Article  Google Scholar 

  22. Croteau SE, Liang MG, Kozakewich HP, Alomari AI, Fishman SJ, Mulliken JB, Trenor CC III (2013) Kaposiform hemangioendothelioma: atypical features and risks of Kasabach-Merritt phenomenon in 107 referrals. J Pediatr 162(1):142–147

    Article  Google Scholar 

  23. Mocellin S (2021) Tufted hemangioma. In: InSoft tissue tumors. Springer, Cham, S 777–778

    Chapter  Google Scholar 

  24. Gbolahan OO, Fasina O, Adisa AO, Fasola OA (2015) Spindle cell hemangioma: Unusual presentation of an uncommon tumor. J Oral Maxillofac Pathol 19:406

    Article  Google Scholar 

  25. Mocellin S (2021) Spindle cell Hemangioma. Insoft tissue tumors. Springer, Cham, S 749–750

    Book  Google Scholar 

  26. Lekwuttikarn R, Chang J, Teng JM (2019) Successful treatment of spindle cell hemangiomas in a patient with Maffucci syndrome and review of literatures. Dermatol Ther 32(3):e12919

    Article  Google Scholar 

  27. Setoyama M, Shimada H, Miyazono N, Baba Y, Kanzaki T (2000) Spindle cell hemangioendothelioma: successful treatment with recombinant interleukin‑2. Br J Dermatol 142(6):1238–1239

    Article  CAS  Google Scholar 

  28. Park J, Yun SK, Cho YS, Song KH, Kim HU (2014) Treatment of angiofibromas in tuberous sclerosis complex: the effect of topical rapamycin and concomitant laser therapy. Dermatology 228(1):37–41. https://doi.org/10.1159/000357033

    Article  PubMed  Google Scholar 

  29. Adler BL, Krausz AE, Minuti A, Silverberg JI, Lev-Tov H (2016) Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): a systematic review. J Am Acad Dermatol 74(3):506–512.e1. https://doi.org/10.1016/j.jaad.2015.10.011

    Article  PubMed  Google Scholar 

  30. Guo R, Gavino ACP (2015) Angiolymphoid hyperplasia with eosinophilia. Arch Pathol Lab Med 139(5):683–686. https://doi.org/10.5858/arpa.2013-0334-RS

    Article  PubMed  Google Scholar 

  31. Cenk H, Kapicioglu Y, Sarac G, Sener S, Sahin N (2020) Recurrent angiolymphoid hyperplasia with eosinophilia during several pregnancies. Dermatol Online J. https://doi.org/10.5070/d3268049890

    Article  PubMed  Google Scholar 

  32. Rongioletti F, Cecchi F, Pastorino C, Scaparro M (2016) Successful management of refractory angiolymphoid hyperplasia with eosinophilia with thalidomide. J Eur Acad Dermatology Venereol 30(3):527–529. https://doi.org/10.1111/jdv.12925

    Article  CAS  Google Scholar 

  33. de Bastos JT, e Silva PMC, Cassia FF, da Rocha CRM, de Freitas BMP, Avelleira JCR (2017) Angiolymphoid hyperplasia with eosinophilia versus Kimura’s disease: a case report and a clinical and histopathological comparison. An Bras Dermatol 92(3):392–394. https://doi.org/10.1590/abd1806-4841.20175318

    Article  PubMed  PubMed Central  Google Scholar 

  34. Sarwal P, Lapumnuaypol K (2020) Pyogenic granuloma. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island

    Google Scholar 

  35. Giblin AV, Clover AJ, Athanassopoulos A, Budny PG (2007) Pyogenic granuloma—the quest for optimum treatment: audit of treatment of 408 cases. J Plast Reconstr Aesthet Surg 60(9):1030–1035. https://doi.org/10.1016/j.bjps.2006.10.018

    Article  CAS  PubMed  Google Scholar 

  36. Cardoso JA, Spanemberg JC, Cherubini K, Figueiredo MA, Salum FG (2013) Oral granuloma gravidarum: a retrospective study of 41 cases in Southern Brazil. J Appl Oral Sci 21(3):215–218. https://doi.org/10.1590/1679-775720130001

    Article  PubMed  PubMed Central  Google Scholar 

  37. Arbiser JL, Weiss SW, Arbiser ZK, Bravo F, Govindajaran B, Caceres-Rios H, Cotsonis G, Recavarren S, Swerlick RA, Cohen C (2001) Differential expression of active mitogen-activated protein kinase in cutaneous endothelial neoplasms: implications for biologic behavior and response to therapy. J Am Acad Dermatol 44(2):193–197. https://doi.org/10.1067/mjd.2000.111632

    Article  CAS  PubMed  Google Scholar 

  38. Benedetto C, Crasto D, Ettefagh L, Nami N (2019) Development of periungual pyogenic granuloma with associated paronychia following Isotretinoin therapy: a case report and a review of the literature. J Clin Aesthet Dermatol 12(4):32–36

    PubMed  PubMed Central  Google Scholar 

  39. Wagner G, Abbenseth R, Heine M, Rose C, Sachse MM (2020) Satellitenrezidiv bei Granuloma pyogenicum [Pyogenic granuloma with satellitosis]. Hautarzt 71(3):219–222. https://doi.org/10.1007/s00105-019-04497-y

    Article  CAS  PubMed  Google Scholar 

  40. Romero-Morales VA, Marchese A, Miserocchi E, Bandello F, Modorati G (2021) Pyogenic granuloma after cosmetic eye whitening. Arch Soc Esp Oftalmol 96(2):89–92. https://doi.org/10.1016/j.oftal.2020.06.034

    Article  CAS  PubMed  Google Scholar 

  41. Herwig-Carl MC, Grossniklaus HE, Müller PL, Atzrodt L, Loeffler KU, Auw-Haedrich C (2019) Pyogenic granuloma associated with conjunctival epithelial neoplasia: report of nine cases. Br J Ophthalmol 103(10):1469–1474. https://doi.org/10.1136/bjophthalmol-2018-312960

    Article  PubMed  Google Scholar 

  42. Kissou A, Hassam BE (2017) Dermoscopy of pyogenic granuloma. Pan Afr Med J 13(27):110. https://doi.org/10.11604/pamj.2017.27.110.12278

    Article  Google Scholar 

  43. Marla V, Shrestha A, Goel K, Shrestha S (2016) The histopathological spectrum of pyogenic granuloma: a case series. Case Rep Dent 2016:1323798. https://doi.org/10.1155/2016/1323798

    Article  PubMed  PubMed Central  Google Scholar 

  44. Plachouri KM, Georgiou S (2019) Therapeutic approaches to pyogenic granuloma: an updated review. Int J Dermatol 58(6):642–648. https://doi.org/10.1111/ijd.14268

    Article  PubMed  Google Scholar 

  45. Cai Z, Thomas J, Alava I 3rd, Aakash N, Saluja K, Zhu H (2019) Fetal type Rhabdomyoma of the soft palate in an adult patient: report of one case and review of the literature. Head Neck Pathol 13(2):182–187. https://doi.org/10.1007/s12105-018-0931-5

    Article  PubMed  Google Scholar 

  46. Ghosh S, Milunski MR (2021) Cardiac rhabdomyoma in adult. Cureus 13(4):e14565. https://doi.org/10.7759/cureus.14565

    Article  PubMed  PubMed Central  Google Scholar 

  47. Müller H, Kutzner H (2019) Neoplasias and hyperplasias of muscular and neural origin. In: Orringer JS, McMichael AJ, Margolis DJ, Enk AH, Bruckner AL, Amagai M, Kang S (Hrsg) Fitzpatrick dermatology, 9. Aufl. McGraw-Hill, New York, S 2143–2144

    Google Scholar 

  48. Mocellin S (2021) Spindle cell hemangioma. In: Soft tissue tumors. Springer, Cham, S 63–370

    Chapter  Google Scholar 

  49. Moriarty J, Sottile J, Thakurdial T, Wrzolek M, Liu Y (2019) Angioleiomyoma of the foot. J Am Podiatr Med Assoc 109(5):397–400. https://doi.org/10.7547/17-083

    Article  PubMed  Google Scholar 

  50. del Olmo J, Marquina M, Redondo P (2007) Angioleiomioma digital asintomático [Asymptomatic digital angioleiomyoma]. Actas Dermosifiliogr 98(4):292–293

    Article  Google Scholar 

  51. Mehta PD, Desai N, Makwana K, Patel Y (2020) Angioleiomyoma of the lowerlip. Ann Maxillofac Surg 10(1):251–253. https://doi.org/10.4103/ams.ams_275_19

    Article  PubMed  PubMed Central  Google Scholar 

  52. Mocellin S (2021) Spindle cell hemangioma. In: Soft tissue tumors. Springer, Cham, S 85–86

    Chapter  Google Scholar 

  53. Sakamoto A, Okamoto T, Matsuda S (2018) Subcutaneous lipomas: a minimally invasive method for resection of subcutaneous lipomas preserving retaining ligaments. Eur J Plast Surg 41(2):173–176. https://doi.org/10.1007/s00238-017-1328-5

    Article  PubMed  Google Scholar 

  54. Arabadzhieva E, Yonkov A, Bonev S, Bulanov D, Taneva I, Ivanova V, Dimitrova V (2015) A rare combination between familial multiple lipomatosis and extragastrointestinal stromal tumor. Int J Surg Case Rep 14:117–120. https://doi.org/10.1016/j.ijscr.2015.07.027

    Article  PubMed  PubMed Central  Google Scholar 

  55. Enzi G, Busetto L, Ceschin E, Coin A, Digito M, Pigozzo S (2002) Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study. Int J Obes Relat Metab Disord 26(2):253–261. https://doi.org/10.1038/sj.ijo.0801867

    Article  CAS  PubMed  Google Scholar 

  56. Charifa A, Azmat CE, Badri T (2021) Lipoma pathology. [Updated 2020 Sep 21]. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482343/. Zugegriffen: 25. Aug. 2021

  57. Chen CM, Lo LJ, Wong HF (2002) Congenital infi ltrating lipomatosis of the face: case report and literature review. Chang Gung Med J 25:194–200

    PubMed  Google Scholar 

  58. Charifa A, Azmat CE, Badri T (2021) Lipoma pathology. [Updated 2020 Sep 21]. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482343/. Zugegriffen: 25. Aug. 2021

  59. Rotunda AM, Ablon G, Kolodney MS (2005) Lipomas treated with subcutaneous deoxycholate injections. J Am Acad Dermatol 53(6):973–978. https://doi.org/10.1016/j.jaad.2005.07.068

    Article  PubMed  Google Scholar 

  60. Karaali MG, Polat AK, Koku Aksu AE, Leblebici C, Gurel MS (2019) Solitary noninfiltrating angiolipoma on the finger, an unusual localization. Dermatol Online J 25(2):13030/qt72p1g8g4

    Article  Google Scholar 

  61. Mentzel T, Brenn T (2019) Lipogenic neoplasms. In: Orringer JS, McMichael AJ, Margolis DJ, Enk AH, Bruckner AL, Amagai M, Kang S (Hrsg) Fitzpatrick dermatology, 9. Aufl. McGraw-Hill, New York, S 2178

    Google Scholar 

  62. Fotiadis A, Ioannidis P, Skandalos I, Papastergiou S, Vrettakos A, Tzigkalidis T, Vampertzis T (2021) Giant posttraumatic angiolipoma of the forearm: a case report and review of the literature. Case Rep Orthop 2021:4047777. https://doi.org/10.1155/2021/4047777

    Article  PubMed  PubMed Central  Google Scholar 

  63. AlQattan AS, Al Abdrabalnabi AA, Al Duhileb MA, Ewies T, Mashhour M, Abbas A (2020) A diagnostic dilemma of a subcutaneous hibernoma: case report. Am J Case Rep 21:e921447. https://doi.org/10.12659/AJCR.921447

    Article  PubMed  PubMed Central  Google Scholar 

  64. Myslicki FA, Rosenberg AE, Chaitowitz I, Subhawong TK (2019) Intraosseous hibernoma: five cases and a review of the literature. J Comput Assist Tomogr 43(5):793–798. https://doi.org/10.1097/RCT.0000000000000912

    Article  PubMed  Google Scholar 

  65. Marcoval J, Sabaté-Llobera A, Bermejo J, Fornons-Servent R (2020) Hibernoma as an incidental finding in the 18F-FDG PET/CT of a patient with melanoma. Melanoma Res 30(4):420–422. https://doi.org/10.1097/CMR.0000000000000530

    Article  CAS  PubMed  Google Scholar 

  66. Lima CS, de Souza MB, dos Santos TBP, Issa MCA, Góes HFO, Vilar EAG (2017) Nevus lipomatosus cutaneous superficialis. An Bras Dermatol 92(5):711–713. https://doi.org/10.1590/abd1806-4841.20175217

    Article  PubMed  PubMed Central  Google Scholar 

  67. Khandpur S, Nagpal SA, Chandra S, Sharma VK, Kaushal S, Safaya R (2009) Giant nevus lipomatosus cutaneous superficialis. Indian J Dermatol Venereol Leprol 75(4):407–408. https://doi.org/10.4103/0378-6323.53149

    Article  PubMed  Google Scholar 

  68. Goucha S, Khaled A, Zéglaoui F, Fazaa B, Rammeh S, Zermani R (2011) Nevus lipomatosus cutaneous superfcialis: report of eight cases. Dermatol Ther (Heidelb) 2(1):25–30. https://doi.org/10.1007/s13555-011-0006-y

    Article  Google Scholar 

  69. Pujani M, Choudhury M, Garg T, Madan N (2014) Nevus lipomatosus superficialis: a rare cutaneous hamartoma. Indian Dermatol Online J 5(1):109. https://doi.org/10.4103/2229-5178.126069

    Article  PubMed  PubMed Central  Google Scholar 

  70. Nakamura Y, Inoue S, Okiyama N, Fujisawa Y (2020) Inverted nipple-like nevus lipomatosus cutaneous superficialis. Jpn J Clin Oncol 50(6):722–723. https://doi.org/10.1093/jjco/hyz201

    Article  PubMed  Google Scholar 

  71. Kim YJ, Choi JH, Kim H, Nam SH, Choi YW (2012) Recurrence of nevus lipomatosus cutaneous superfcialis afer CO2 laser treatment. Arch Plast Surg 39(6):671–673. https://doi.org/10.5999/aps.2012.39.6.671

    Article  PubMed  PubMed Central  Google Scholar 

  72. Castagna RD, Benvegnú AM, Dallazem LND, Brutti CS (2018) Topical corticosteroid therapy: a treatment option for nevus lipomatosus cutaneous superficialis? An Bras Dermatol 93(1):158. https://doi.org/10.1590/ABD1806-4841.20186986

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to Bogdan Mastalier.

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A.-I. Butacu, I.-E. Negulet, E.-D. Boieriu, I.-S. Dinu, A. Mihalache, B. Mastalier, C.M. Salavastru, K. Fritz und G.-S. Tiplica geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Für Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, über die Patienten zu identifizieren sind, liegt von ihnen und/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.

Übersetzung aus dem Englischen: Ansgar Schlichting

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Butacu, AI., Negulet, IE., Boieriu, ED. et al. Häufigste benigne Gefäß‑, Muskel- und Fettgewebstumoren der Haut und ihre Therapie. Hautarzt 73, 104–113 (2022). https://doi.org/10.1007/s00105-021-04926-x

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