Zusammenfassung
Benigne kutane Gefäßtumoren sowie Hauttumoren, die aus Muskel- oder Fettgewebe hervorgehen, sind selten. Ihre Definition und Klassifikation ist noch umstritten. Histopathologische und immunhistochemische Untersuchungen tragen zusammen mit den neuen Gentests wesentlich zur korrekten Beschreibung der verschiedenen benignen Tumoren kutanen Ursprungs bei. Die Benignität der Läsion abzuklären ist von grundlegender Bedeutung für die Prognose und das therapeutische Vorgehen. In den meisten Fällen stellt die schlichte chirurgische Entfernung die Therapie der Wahl dar. Dermatologen sollten die bestehende Klassifikation der häufigsten benignen Gefäß‑, Muskel- und Fettgewebstumoren der Haut kennen und die gegenwärtig für eine genaue Diagnose eingesetzten Verfahren empfehlen können. Die Sicherung der Benignität einer Läsion und ein gutes operatives Ergebnis sind für den Patienten essenziell.
Abstract
Benign cutaneous vascular and cutaneous neoplasms arising from muscle or adipose tissue are rare. Their definition and classification are still controversially discussed. Histopathological and immunohistochemical studies, together with the new genetic tests, contribute significantly to the correct description of the various benign neoplasms of cutaneous origin. Clarifying whether a lesion is benign is fundamental for prognosis and therapeutic management. In most cases, surgical excision is the treatment of choice. Dermatologists should be familiar with the classifications of the most common benign cutaneous neoplasms of vascular, muscular, and adipose tissue and be able to recommend the procedures currently used for an accurate diagnosis. Ensuring that a lesion is benign and a good surgical outcome are essential for the patient.
Literatur
Becker JC, Atzwanger BL, Ugurel S et al (2011) Section 23: tumors and hyperplasias of the dermis and subcutaneous fat. In: Wolff K, Goldsmith L, Katz S, Gilchrest B, Paller AS, Leffell D (Hrsg) Fitzpatrick’s dermatology in general medicine, 8. Aufl. McGraw-Hill, New York, S 1456–1480
Calonje E (2010) Chapter 56: soft-tissue tumours and tumour-like conditions. In: Rook A, In Burns T (Hrsg) Rook’s textbook of dermatology. Wiley-Blackwell, Chichester, West Sussex, UK, S 25–56
Burgdorf WHC, Plewig G, Wolff HH, Landthaler M, Braun-Falco O (Hrsg) (2008) Braun-Falco´s Dermatology. Springer, Heidelberg, S 1442–1468
Calonje E, Brenn T (2015) Chapter 33 vascular tumors: tumors and tumorlike conditions of blood vessels and Lymphatics. In: Elder D, Elenitsas R, Rosenbach M, Murphy G, Rubin A, Xu X (Hrsg) Lever’s histopathology of the skin, 11. Aufl. Wolters Kluwer, Dordrecht, S 2643–2793
Moore JB, Ragsdale B (2015) Chapter 43 tumors with fatty, muscular, osseous, and/or cartilaginous differentiation. In: Elder D, Elenitsas R, Rosenbach M, Murphy G, Rubin A, Xu X (Hrsg) Lever’s histopathology of the skin, 11. Aufl. Wolters Kluwer, Dordrecht, S 2794–2900
Saurat JH (2004) Lipsker. [Maladies dex vaisseaux]. In: Saurat JH, Grosshans E, Laugier P, Lachapelle JM (Hrsg) Dermatologie et infections sexuellement transmissibles, 4. Aufl. Elsevier, Masson, S 693–708
International Society for the Study of Vascular Anomalies ISSVA classification of vascular anomalies 2018.. Zugegriffen: 1. Nov. 2021
Mocellin S (2021) Congenital hemangioma. In: Soft tissue tumors. Springer, Cham, S 181–183
Lee PW, Frieden IJ, Streicher JL, McCalmont T, Haggstrom AN (2014) Characteristics of noninvoluting congenital hemangioma: a retrospective review. J Am Acad Dermatol 70(5):899–903
Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HP, Bischoff J, Greene AK (2016) Somatic activating mutations in GNAQ and GNA11 are associated with congenital hemangioma. Am J Hum Genet 98(4):789–795
Tiemann L, Hein S (2020) Infantile hemangioma: a review of current pharmacotherapy treatment and practice pearls. J Pediatr Pharmacol Ther 25(7):586–599. https://doi.org/10.5863/1551-6776-25.7.586
Satterfield KR, Chambers CB (2019) Current treatment and management of infantile hemangiomas. Surv Ophthalmol 64(5):608–618. https://doi.org/10.1016/j.survophthal.2019.02.005
Mathes EF, Frieden IJ (2019) Chapter 126: vascular tumors. In: Orringer JS, McMichael AJ, Margolis DJ, Enk AH, Bruckner AL, Amagai M, Kang S (Hrsg) Fitzpatrick dermatology, 9. Aufl. McGraw-Hill, New York, S 2042–2045
Smith CJF, Friedlander SF, Guma M, Kavanaugh A, Chambers CD (2017) Infantile hemangiomas: an updated review on risk factors, pathogenesis, and treatment. Birth Defects Res 109(11):809–815. https://doi.org/10.1002/bdr2.1023
Iacobas I, Phung TL, Adams DM et al (2018) Guidance document for hepatic hemangioma (infantile and congenital) evaluation and monitoring. J Pediatr 203:294
Kerns ML, Chien AL, Kang S (2019) Chapter 106: skin aging. In: Orringer JS, McMichael AJ, Margolis DJ, Enk AH, Bruckner AL, Amagai M, Kang S (Hrsg) Fitzpatrick dermatology, 9. Aufl. McGraw-Hill, New York, S 1785–1788
Higgins JC, Maher MH, Douglas MS (2015) Diagnosing common benign skin tumors. Am Fam Physician 92(7):601–607
Nazer RI, Bashihab RH, Al-Madani WH, Omair AA, AlJasser MI (2020) Cherry angioma: a case-control study. J Family Community Med 27(2):109–113. https://doi.org/10.4103/jfcm.JFCM_293_19
Mehta AB, Orteu CH. (2019) Fabry disease. In: Orringer JS, McMichael AJ, Margolis DJ, Enk AH, Bruckner AL, Amagai M, Kang S (Hrsg) Fitzpatrick dermatology, 9. Aufl. McGraw-Hill, New York, S 2295
Qadeer HA, Singal A, Patel BC (2021) Cherry hemangioma. In: StatPearls, Bd. 33085354. StatPearls Publishing, Treasure Island
Feito-Rodríguez M, Sánchez-Orta A, De Lucas R, López-Gutiérrez JC, Ruiz-Bravo E, Baselga E, Victoria AM, Hernández-Martín A, Campos-Domínguez M, Berenguer Fröhner B, Garnacho-Saucedo G (2018) Congenital tufted angioma: a multicenter retrospective study of 30 cases. Pediatr Dermatol 35(6):808–816
Croteau SE, Liang MG, Kozakewich HP, Alomari AI, Fishman SJ, Mulliken JB, Trenor CC III (2013) Kaposiform hemangioendothelioma: atypical features and risks of Kasabach-Merritt phenomenon in 107 referrals. J Pediatr 162(1):142–147
Mocellin S (2021) Tufted hemangioma. In: InSoft tissue tumors. Springer, Cham, S 777–778
Gbolahan OO, Fasina O, Adisa AO, Fasola OA (2015) Spindle cell hemangioma: Unusual presentation of an uncommon tumor. J Oral Maxillofac Pathol 19:406
Mocellin S (2021) Spindle cell Hemangioma. Insoft tissue tumors. Springer, Cham, S 749–750
Lekwuttikarn R, Chang J, Teng JM (2019) Successful treatment of spindle cell hemangiomas in a patient with Maffucci syndrome and review of literatures. Dermatol Ther 32(3):e12919
Setoyama M, Shimada H, Miyazono N, Baba Y, Kanzaki T (2000) Spindle cell hemangioendothelioma: successful treatment with recombinant interleukin‑2. Br J Dermatol 142(6):1238–1239
Park J, Yun SK, Cho YS, Song KH, Kim HU (2014) Treatment of angiofibromas in tuberous sclerosis complex: the effect of topical rapamycin and concomitant laser therapy. Dermatology 228(1):37–41. https://doi.org/10.1159/000357033
Adler BL, Krausz AE, Minuti A, Silverberg JI, Lev-Tov H (2016) Epidemiology and treatment of angiolymphoid hyperplasia with eosinophilia (ALHE): a systematic review. J Am Acad Dermatol 74(3):506–512.e1. https://doi.org/10.1016/j.jaad.2015.10.011
Guo R, Gavino ACP (2015) Angiolymphoid hyperplasia with eosinophilia. Arch Pathol Lab Med 139(5):683–686. https://doi.org/10.5858/arpa.2013-0334-RS
Cenk H, Kapicioglu Y, Sarac G, Sener S, Sahin N (2020) Recurrent angiolymphoid hyperplasia with eosinophilia during several pregnancies. Dermatol Online J. https://doi.org/10.5070/d3268049890
Rongioletti F, Cecchi F, Pastorino C, Scaparro M (2016) Successful management of refractory angiolymphoid hyperplasia with eosinophilia with thalidomide. J Eur Acad Dermatology Venereol 30(3):527–529. https://doi.org/10.1111/jdv.12925
de Bastos JT, e Silva PMC, Cassia FF, da Rocha CRM, de Freitas BMP, Avelleira JCR (2017) Angiolymphoid hyperplasia with eosinophilia versus Kimura’s disease: a case report and a clinical and histopathological comparison. An Bras Dermatol 92(3):392–394. https://doi.org/10.1590/abd1806-4841.20175318
Sarwal P, Lapumnuaypol K (2020) Pyogenic granuloma. In: StatPearls [Internet]. StatPearls Publishing, Treasure Island
Giblin AV, Clover AJ, Athanassopoulos A, Budny PG (2007) Pyogenic granuloma—the quest for optimum treatment: audit of treatment of 408 cases. J Plast Reconstr Aesthet Surg 60(9):1030–1035. https://doi.org/10.1016/j.bjps.2006.10.018
Cardoso JA, Spanemberg JC, Cherubini K, Figueiredo MA, Salum FG (2013) Oral granuloma gravidarum: a retrospective study of 41 cases in Southern Brazil. J Appl Oral Sci 21(3):215–218. https://doi.org/10.1590/1679-775720130001
Arbiser JL, Weiss SW, Arbiser ZK, Bravo F, Govindajaran B, Caceres-Rios H, Cotsonis G, Recavarren S, Swerlick RA, Cohen C (2001) Differential expression of active mitogen-activated protein kinase in cutaneous endothelial neoplasms: implications for biologic behavior and response to therapy. J Am Acad Dermatol 44(2):193–197. https://doi.org/10.1067/mjd.2000.111632
Benedetto C, Crasto D, Ettefagh L, Nami N (2019) Development of periungual pyogenic granuloma with associated paronychia following Isotretinoin therapy: a case report and a review of the literature. J Clin Aesthet Dermatol 12(4):32–36
Wagner G, Abbenseth R, Heine M, Rose C, Sachse MM (2020) Satellitenrezidiv bei Granuloma pyogenicum [Pyogenic granuloma with satellitosis]. Hautarzt 71(3):219–222. https://doi.org/10.1007/s00105-019-04497-y
Romero-Morales VA, Marchese A, Miserocchi E, Bandello F, Modorati G (2021) Pyogenic granuloma after cosmetic eye whitening. Arch Soc Esp Oftalmol 96(2):89–92. https://doi.org/10.1016/j.oftal.2020.06.034
Herwig-Carl MC, Grossniklaus HE, Müller PL, Atzrodt L, Loeffler KU, Auw-Haedrich C (2019) Pyogenic granuloma associated with conjunctival epithelial neoplasia: report of nine cases. Br J Ophthalmol 103(10):1469–1474. https://doi.org/10.1136/bjophthalmol-2018-312960
Kissou A, Hassam BE (2017) Dermoscopy of pyogenic granuloma. Pan Afr Med J 13(27):110. https://doi.org/10.11604/pamj.2017.27.110.12278
Marla V, Shrestha A, Goel K, Shrestha S (2016) The histopathological spectrum of pyogenic granuloma: a case series. Case Rep Dent 2016:1323798. https://doi.org/10.1155/2016/1323798
Plachouri KM, Georgiou S (2019) Therapeutic approaches to pyogenic granuloma: an updated review. Int J Dermatol 58(6):642–648. https://doi.org/10.1111/ijd.14268
Cai Z, Thomas J, Alava I 3rd, Aakash N, Saluja K, Zhu H (2019) Fetal type Rhabdomyoma of the soft palate in an adult patient: report of one case and review of the literature. Head Neck Pathol 13(2):182–187. https://doi.org/10.1007/s12105-018-0931-5
Ghosh S, Milunski MR (2021) Cardiac rhabdomyoma in adult. Cureus 13(4):e14565. https://doi.org/10.7759/cureus.14565
Müller H, Kutzner H (2019) Neoplasias and hyperplasias of muscular and neural origin. In: Orringer JS, McMichael AJ, Margolis DJ, Enk AH, Bruckner AL, Amagai M, Kang S (Hrsg) Fitzpatrick dermatology, 9. Aufl. McGraw-Hill, New York, S 2143–2144
Mocellin S (2021) Spindle cell hemangioma. In: Soft tissue tumors. Springer, Cham, S 63–370
Moriarty J, Sottile J, Thakurdial T, Wrzolek M, Liu Y (2019) Angioleiomyoma of the foot. J Am Podiatr Med Assoc 109(5):397–400. https://doi.org/10.7547/17-083
del Olmo J, Marquina M, Redondo P (2007) Angioleiomioma digital asintomático [Asymptomatic digital angioleiomyoma]. Actas Dermosifiliogr 98(4):292–293
Mehta PD, Desai N, Makwana K, Patel Y (2020) Angioleiomyoma of the lowerlip. Ann Maxillofac Surg 10(1):251–253. https://doi.org/10.4103/ams.ams_275_19
Mocellin S (2021) Spindle cell hemangioma. In: Soft tissue tumors. Springer, Cham, S 85–86
Sakamoto A, Okamoto T, Matsuda S (2018) Subcutaneous lipomas: a minimally invasive method for resection of subcutaneous lipomas preserving retaining ligaments. Eur J Plast Surg 41(2):173–176. https://doi.org/10.1007/s00238-017-1328-5
Arabadzhieva E, Yonkov A, Bonev S, Bulanov D, Taneva I, Ivanova V, Dimitrova V (2015) A rare combination between familial multiple lipomatosis and extragastrointestinal stromal tumor. Int J Surg Case Rep 14:117–120. https://doi.org/10.1016/j.ijscr.2015.07.027
Enzi G, Busetto L, Ceschin E, Coin A, Digito M, Pigozzo S (2002) Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study. Int J Obes Relat Metab Disord 26(2):253–261. https://doi.org/10.1038/sj.ijo.0801867
Charifa A, Azmat CE, Badri T (2021) Lipoma pathology. [Updated 2020 Sep 21]. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482343/. Zugegriffen: 25. Aug. 2021
Chen CM, Lo LJ, Wong HF (2002) Congenital infi ltrating lipomatosis of the face: case report and literature review. Chang Gung Med J 25:194–200
Charifa A, Azmat CE, Badri T (2021) Lipoma pathology. [Updated 2020 Sep 21]. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK482343/. Zugegriffen: 25. Aug. 2021
Rotunda AM, Ablon G, Kolodney MS (2005) Lipomas treated with subcutaneous deoxycholate injections. J Am Acad Dermatol 53(6):973–978. https://doi.org/10.1016/j.jaad.2005.07.068
Karaali MG, Polat AK, Koku Aksu AE, Leblebici C, Gurel MS (2019) Solitary noninfiltrating angiolipoma on the finger, an unusual localization. Dermatol Online J 25(2):13030/qt72p1g8g4
Mentzel T, Brenn T (2019) Lipogenic neoplasms. In: Orringer JS, McMichael AJ, Margolis DJ, Enk AH, Bruckner AL, Amagai M, Kang S (Hrsg) Fitzpatrick dermatology, 9. Aufl. McGraw-Hill, New York, S 2178
Fotiadis A, Ioannidis P, Skandalos I, Papastergiou S, Vrettakos A, Tzigkalidis T, Vampertzis T (2021) Giant posttraumatic angiolipoma of the forearm: a case report and review of the literature. Case Rep Orthop 2021:4047777. https://doi.org/10.1155/2021/4047777
AlQattan AS, Al Abdrabalnabi AA, Al Duhileb MA, Ewies T, Mashhour M, Abbas A (2020) A diagnostic dilemma of a subcutaneous hibernoma: case report. Am J Case Rep 21:e921447. https://doi.org/10.12659/AJCR.921447
Myslicki FA, Rosenberg AE, Chaitowitz I, Subhawong TK (2019) Intraosseous hibernoma: five cases and a review of the literature. J Comput Assist Tomogr 43(5):793–798. https://doi.org/10.1097/RCT.0000000000000912
Marcoval J, Sabaté-Llobera A, Bermejo J, Fornons-Servent R (2020) Hibernoma as an incidental finding in the 18F-FDG PET/CT of a patient with melanoma. Melanoma Res 30(4):420–422. https://doi.org/10.1097/CMR.0000000000000530
Lima CS, de Souza MB, dos Santos TBP, Issa MCA, Góes HFO, Vilar EAG (2017) Nevus lipomatosus cutaneous superficialis. An Bras Dermatol 92(5):711–713. https://doi.org/10.1590/abd1806-4841.20175217
Khandpur S, Nagpal SA, Chandra S, Sharma VK, Kaushal S, Safaya R (2009) Giant nevus lipomatosus cutaneous superficialis. Indian J Dermatol Venereol Leprol 75(4):407–408. https://doi.org/10.4103/0378-6323.53149
Goucha S, Khaled A, Zéglaoui F, Fazaa B, Rammeh S, Zermani R (2011) Nevus lipomatosus cutaneous superfcialis: report of eight cases. Dermatol Ther (Heidelb) 2(1):25–30. https://doi.org/10.1007/s13555-011-0006-y
Pujani M, Choudhury M, Garg T, Madan N (2014) Nevus lipomatosus superficialis: a rare cutaneous hamartoma. Indian Dermatol Online J 5(1):109. https://doi.org/10.4103/2229-5178.126069
Nakamura Y, Inoue S, Okiyama N, Fujisawa Y (2020) Inverted nipple-like nevus lipomatosus cutaneous superficialis. Jpn J Clin Oncol 50(6):722–723. https://doi.org/10.1093/jjco/hyz201
Kim YJ, Choi JH, Kim H, Nam SH, Choi YW (2012) Recurrence of nevus lipomatosus cutaneous superfcialis afer CO2 laser treatment. Arch Plast Surg 39(6):671–673. https://doi.org/10.5999/aps.2012.39.6.671
Castagna RD, Benvegnú AM, Dallazem LND, Brutti CS (2018) Topical corticosteroid therapy: a treatment option for nevus lipomatosus cutaneous superficialis? An Bras Dermatol 93(1):158. https://doi.org/10.1590/ABD1806-4841.20186986
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Interessenkonflikt
A.-I. Butacu, I.-E. Negulet, E.-D. Boieriu, I.-S. Dinu, A. Mihalache, B. Mastalier, C.M. Salavastru, K. Fritz und G.-S. Tiplica geben an, dass kein Interessenkonflikt besteht.
Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien. Für Bildmaterial oder anderweitige Angaben innerhalb des Manuskripts, über die Patienten zu identifizieren sind, liegt von ihnen und/oder ihren gesetzlichen Vertretern eine schriftliche Einwilligung vor.
Übersetzung aus dem Englischen: Ansgar Schlichting
Additional information
Alle Autoren haben in gleichem Maße zu dieser Arbeit beigetragen.
QR-Code scannen & Beitrag online lesen
Rights and permissions
About this article
Cite this article
Butacu, AI., Negulet, IE., Boieriu, ED. et al. Häufigste benigne Gefäß‑, Muskel- und Fettgewebstumoren der Haut und ihre Therapie. Hautarzt 73, 104–113 (2022). https://doi.org/10.1007/s00105-021-04926-x
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00105-021-04926-x