Skip to main content
SpringerLink
Log in

Alitretinoin und Off-label-Use

Off-label use of alitretinoin

  • Leitthema
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

Orales Alitretinoin (9-cis-Retinsäure) ist ein körpereigenes Retinoid, das mit Vitamin A verwandt ist. Studien haben gezeigt, dass orales Alitretinoin wirksam und auch gut verträglich in der Behandlung des schweren chronischen Handekzems ist und für diese Indikation auch die Zulassung hat. Diese Übersichtsarbeit fasst aktuelle Studienergebnisse und Erfahrungsberichte zu anderen Indikationen („off-label“) mit Alitretinoin zusammen.

Abstract

Oral alitretinoin (9-cis retinoic acid) is an endogenous retinoid related to vitamin A. Studies have shown that oral alitretinoin is effective and well-tolerated in the treatment of severe chronic hand eczema, so that it is approved for this indication. This review summarizes new studies and clinical experience on the off-label use of alitretinoin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Abu J, Batuwangala M, Herbert K, Symonds P (2005) Retinoic acid and retinoid receptors: potential chemo preventive and therapeutic role in cervical cancer. Lancet Oncol 6(9):712–720

    Article  PubMed  CAS  Google Scholar 

  2. Anolik JH, Giovanna JJD, Gaspari AA (1998) Effect of isotretinoin therapy on natural killer cell activity in patients with xeroderma pigmentosum. Br J Dermatol 138(2):236–241

    Article  PubMed  CAS  Google Scholar 

  3. Barnstedt SE (2012) Erfolgreiche Therapie eines Morbus Darier mit Alitretinoin. Hautarzt 2:139–141

    Article  Google Scholar 

  4. Baumann L, Vujevich J, Halem M et al (2005) Open-label pilot study of alitretinoin gel 0.1 % in the treatment of photoaging. Cutis 76(1):69–73

    PubMed  Google Scholar 

  5. Carneiro RV, Sotto MN, Azavedo LS et al (2005) Acitretin and skin cancer in kidney transplanted patients. Clinical and histological evaluation and immunohistochemical analysis of lymphocytes, natural killer cells and Langerhans‘ cells in sun exposed and sun protected skin. Clin Transplant 19(1):115–121

    Article  PubMed  Google Scholar 

  6. Chen K, Craig JC, Shumack S (2005) Oral retinoids for the prevention of skin cancers in solid organ transplant recipients: a systematic review of randomized controlled trials. Br J Dermatol 152(3):518–523

    Article  PubMed  CAS  Google Scholar 

  7. Degos L (1990) Differentiating agents in the treatment of leukemia. Leuk Res 14(8):717–719

    Article  PubMed  CAS  Google Scholar 

  8. Emmert B, Hallier E et al (2011) Response of recalcitrant lichen planus to alitretinoin in 3 patients. J Am Acad Dermatol 65(2):58–60

    Article  Google Scholar 

  9. Fritz K (2011) Therapieerfolg trotz latent aktivierbarer Poliomyelitis – ein Fallbericht. Dtsch Dermatol 11:2–3

    Google Scholar 

  10. Gånemo A, Sommerlund M, Vahlquist A (2012) Oral Alitretinoin in congenital Ichthyosis: a pilot study shows variable effects and a risk of central hypothyroidism. Acta Derm Venereol 92:256–257

    Article  PubMed  Google Scholar 

  11. Grahovac M, Molin S, Prinz J et al (2010) Treatment of atopic eczema with oral alitretinoin. Br J Dermatol 162(1):217–218

    Article  PubMed  CAS  Google Scholar 

  12. Han JY, Liu DD, Lee JJ et al (2005) 9-cis-retinoic acid treatment increases serum concentrations of α-tocopherol in former smokers. Clin Cancer Res 11(6):2305–2311

    Article  PubMed  CAS  Google Scholar 

  13. Irla N, Navarini A, Yawalkar N (2012) Alitretinoin abrogates innate inflammation in palmoplantar pustular psoriasis. Br J Dermatol 167(5):1170–1174

    Article  PubMed  CAS  Google Scholar 

  14. Jungersted JM, Høgh JK, Hellgren LI et al (2010) Changes in skin barrier during treatment with systemic alitretinoin: focus on skin susceptibility and stratum corneum ceramides. Arch Dermatol Res 302(9):653–666

    Article  PubMed  CAS  Google Scholar 

  15. Kolesnik M, Gollnick H, Bonnekob B (2013) Complete remission of alopecia areata under treatment of chronic hand eczema with alitretinoin. Eur J Dermatol 23(1):110–111

    PubMed  Google Scholar 

  16. Kuhn A, Patsinakidis N, Luger T (2012) Alitretinoin for cutaneous lupus erythematosus. J Am Acad Dermatol 67(3):123–126

    Article  Google Scholar 

  17. Kurie JM, Lotan R, Lee JJ et al (2003) Treatment of former smokers with 9-cis-retinoic acid reverses loss of retinoic acid receptor-β expression in the bronchial epithelium: results from a randomized placebo-controlled trial. J Natl Cancer Inst 95(3):206–214

    Article  PubMed  CAS  Google Scholar 

  18. Lawrence JA, Adamson PC, Caruso R et al (2001) Phase I clinical trial of alitretinoin and tamoxifen in breast cancer patients: toxicity, pharmacokinetic, and biomarker evaluations. J Clin Oncol 15(19):2754–2763

    Google Scholar 

  19. Letulé V, Herzinger T, Ruzicka T, Molin S (2013) Treatment of Darier disease with oral alitretinoin. Clin Exp Dermatol 38(5):523–525

    Article  PubMed  Google Scholar 

  20. Meyer V, Goerge T, Luger TA, Beissert S (2011) Successful treatment of palmoplantar hyperkeratotic psoriasis with a combination of etanercept and alitretinoin. J Clin Aesthet Dermatol 4(4):45–46

    PubMed  Google Scholar 

  21. Molin S, Ruzicka T (2010) Treatment of refractory pityriasis rubra pilaris with oral alitretinoin: case report. Br J Dermatol 163:208–234

    Google Scholar 

  22. Molin S, Ruzicka T (2010) Oral alitretinoin in lichen planus: two case reports. Acta Derm Venerol 90:523–524

    Article  PubMed  Google Scholar 

  23. Molin S, Ruzicka T (2009) Possible benefit of oral alitretinoin in T-Lymphoproliferative disease: a report of two patients with palmoplantar hyperkeratotic-rhagadiform skin changes and mycosis fungoides or Sezary syndrome. Br J Dermatol 161(6):1420–1422

    Article  PubMed  CAS  Google Scholar 

  24. Motschenbacher S, Buder K, Goebler M, Kerstan A (2012) Combined oral alitretinoin and narrowband UVB treatment of cutaneous T cell lymphoma: favourable response after multiple ineffective systemic therapies. Eur J Dermatol 22(6):803–804

    PubMed  Google Scholar 

  25. Noji S, Yamaai T, Koyama E et al (1989) Expression of retinoic acid receptor genes in keratinizing front of skin. FEBS Lett 259(1):86–90

    Article  PubMed  CAS  Google Scholar 

  26. Özkan F, Altmeyer P (2009) Alitretinoin als Therapieoption bei Patienten mit einer beruflich provozierten Psoriasis Palmaris. Dermatol Beruf Umwelt 57(3):119

    Google Scholar 

  27. Pinter A, Pätzold S, Kaufmann R (2011) Lichen planus of nails – successful treatment with Alitretinoin. J Dtsch Dermatol Ges 9(12):1033–1034

    PubMed  Google Scholar 

  28. Petersen B, Jemec GB (2009) Alitretinoin – its use in intractable hand eczema and other potential indications. Drug Des Devel Ther 21(3):51–57

    Google Scholar 

  29. Rizvi NA, Marshall JL, Ness E et al (1998) Phase I study of 9-cis-retinoic acid (ALRT1057) in adults with advanced cancer. Clin Cancer Res 4(6):1437–1442

    PubMed  CAS  Google Scholar 

  30. Sárdy M, Ruzicka T (2013) Successful therapy of refractory Hailey-Hailey disease with oral alitretinoin. Br J Dermatol. doi: 10.1111/bjd.12582 [Epub ahead of print]

  31. Schmitt S, Inhoff O, Dippel E (2011) Oral alitretinoin for the treatment of recalcitrant pityriasis rubra pilaris. Dermatol 18(3):85–88

    Google Scholar 

  32. Schmitz L, Bierhoff E, Dirschka T (2013) Alitretinoin: an effective treatment option for pagetoid reticulosis. J Dtsch Dermatol Ges. doi: 10.1111/ddg.12166 [Epub ahead of print]

  33. Schopf M (2011) Lichen planus secondary to Hepatits B vaccination, Successful treatment by alitretinoin (Poster EADV)

  34. Srown T, Maher T, Astani R (2012) A Case of coexistent palmar/plantar cutaneous T-cell lymphoma and psoriasis treated with alitretinoin. (Poster AAD)

  35. Tejera-Vaquerizo A et al (2012) Successsful treatment of recalcitrant chronic foot eczema. Actas Dermosifiliogr 103(2):931–932

    Article  Google Scholar 

  36. Tosti A, Ricotti C, Romanelli P et al (2009) Evaluation of the efficacy of acitretin therapy for nail psoriasis. Arch Dermatol 145(3):269–271

    Article  PubMed  CAS  Google Scholar 

  37. Werchau S, Toberer F, Enk A, Helmbold P (2011) Keratitis-ichthyosis-deafness syndrome: response to alitretinoin and review of literature. Arch Dermatol 147(2):993–995

    Article  PubMed  Google Scholar 

  38. Wollenberg A (2011) Treatment of Dorfman-Chanarin syndrome with oral alitretinoin (Poster EADV)

  39. Younes A, Cristofanilli M, Mclaughlin P et al (2000) Experience with 9-cis-retinoic acid in patients with relapsed and refractory non-Hodgkin’s lymphoma. Leuk Lymphoma 40(1–2):79–85

    Google Scholar 

  40. Zamiri M, Munro C (2013) Successful treatment with oral alitretinoin in women of child-bearing potential with Darier’s disease. Br J Dermatol. doi: 10.1111/bjd.12348 [Epub ahead of print]

  41. Zouboulis CC (2001) Retinoids-which dermatological indications will benefit in the near future? Skin Pharmacol Appl Skin Physiol 14(5):303–315

    Article  PubMed  CAS  Google Scholar 

Download references

Einhaltung ethischer Richtlinien

Interessenkonflikt. K. Fritz, G.S. Tiplicab, C. Salavastrub und M. Onder geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Author information

Authors and Affiliations

  1. Haut und Laser Centrum – Landau, Reduitstr. 13, 76829, Landau, Deutschland

    K. Fritz & M. Onder

  2. Universität Carol Davila, Bucharest, Romania

    K. Fritz, G.S. Tiplica & C. Salavastru

  3. Universitäten Bern und Osnabrück, Bern, Schweiz

    K. Fritz

  4. Gazi Universität Ankara Medizinische Fakultät , Ankara, Turkey

    M. Onder

Authors
  1. K. Fritz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G.S. Tiplica
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Salavastru
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Onder
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to K. Fritz.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fritz, K., Tiplica, G., Salavastru, C. et al. Alitretinoin und Off-label-Use. Hautarzt 64, 748–751 (2013). https://doi.org/10.1007/s00105-013-2593-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-013-2593-2

Schlüsselwörter

Keywords

Search

Navigation