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Neue und seltener angewandte Therapieoptionen bei therapierefraktärem Handekzem

Lokale UVA-1-Phototherapie, Retinoide, Calcineurininhibitoren

New and rarley used treatment options for refractory hand eczema

Local UVA-1 phototherapy, retinoids, calcineurin inhibitors

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Zusammenfassung

Das Handekzem (HE) gehört zu den häufigsten Hauterkrankungen. Das klinische Bild des HE ist unterschiedlich und variiert aufgrund seiner Ätiologie, Schwere und Morphologie. Das HE wird oftmals durch einen chronisch rezidivierenden Verlauf charakterisiert, hat eine relativ schlechte Prognose und eine hohe Auswirkung auf die Lebensqualität. Obwohl es verschiedene Therapieoptionen gibt, ist die Behandlung von Patienten mit chronischem HE oftmals unbefriedigend. In diesem Beitrag diskutieren wir neue und seltener angewandte Therapieoptionen wie die lokale UVA-1-Phototherapie, die Therapie mit Retinoiden (insbesondere mit dem neuen RXR- und RAR-Retinoid Alitretinoin) und Calcineurininhibitoren (Ciclosporin systemisch, Tacrolimus lokal).

Abstract

Hand eczema (HE) is one of the most frequent skin diseases. HE has a wide spectrum, with variable etiology, severity, and morphology. It often displays a chronically relapsing course with a poor prognosis, and has a high impact on the quality of life. Although different treatment options exist, the management of patients with chronic HE is often unsatisfactory. We highlight new and rarely used approaches to treat chronic HE uncluding local UVA-1-phototherapy, retinoids including the new oral retinoid alitretinoin, and calcineurin inhibitors.

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Interessenkonflikt

Der korrespondierende Autor weist auf folgende Beziehung hin: Referententätigkeit für die Firma Almirau.

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Authors and Affiliations

  1. Klinik für Dermatologie und Venerologie, Medizinische Hochschule Hannover, Ricklinger Straße 5, 30449, Hannover, Deutschland

    U. Raap, C. Kenneweg, A. Kapp & T. Werfel

  2. Abteilung für Immundermatologie und exp. Allergologie, Medizinische Hochschule Hannover, Hannover, Deutschland

    T. Werfel

  3. Hautarztpraxis, Trier, Deutschland

    C. Kenneweg

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  1. U. Raap
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  2. C. Kenneweg
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  3. A. Kapp
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  4. T. Werfel
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Correspondence to U. Raap.

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Raap, U., Kenneweg, C., Kapp, A. et al. Neue und seltener angewandte Therapieoptionen bei therapierefraktärem Handekzem. Hautarzt 59, 710–716 (2008). https://doi.org/10.1007/s00105-008-1561-8

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  • DOI: https://doi.org/10.1007/s00105-008-1561-8

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