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Quality assurance for clinical studies in regional deep hyperthermia

Qualitätssicherung in der regionalen Tiefenhyperthermie

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Background

A guideline is provided for the implementation of regional deep hyperthermia treatments under strict rules of quality assurance. The objective is to guarantee a comparable and comprehensible method in the treatment and scientific analysis of hyperthermia. The guideline describes regional deep hyperthermia (RHT) and MR-controlled partial body hyperthermia (PBH) of children, young and adult patients. According to this guideline, hyperthermia treatment is always applied in combination with chemotherapy and/or radiotherapy.

Methods

The guideline is based on practical experience from several hyperthermia centers. The procedure allows applying jointly coordinated standards and quality control in hyperthermia for studies.

Results

The guideline contains recommendations for hyperthermia treatments, including indication, preparation, treatment, and standardized analysis.

Hintergrund

Zur Durchführung von qualitätsgesicherten Tiefenhyperthermiebehandlungen wurde eine Leitlinie erstellt. Ziel war, ein vergleichbares und nachvollziehbares Vorgehen bei der Behandlung und der wissenschaftlichen Auswertung von Hyperthermiebehandlungen zu gewährleisten. Die Leitlinie beschreibt die „Regionale Tiefenhyperthermie“ (RHT) und die „MR-kontrollierte Teilkörperhyperthermie“ (PBH) von Kindern, jugendlichen und erwachsenen Patienten. Hyperthermie im Sinne der Leitlinie wird als Kombinationsbehandlung mit einer Chemo- und/oder Strahlentherapie durchgeführt.

Methodik

Die Leitlinie basiert auf praktischen Erfahrungen mehrerer Hyperthermiezentren. Dieses Vorgehens erlaubt abgestimmte Standards in der Anwendung und der Qualitätskontrolle in der Hyperthermie für Studien.

Ergebnisse

Diese Leitlinie enthält Empfehlungen für Hyperthermiebehandlungen mit Indikationsstellung, Vorbereitung, Durchführung und standardisierter Auswertung.

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Authors and Affiliations

  1. Department of Radiation Oncology, University Hospital of Freiburg, Freiburg, Germany

    Gregor Bruggmoser, Marc Benjamin Messmer & Andreas Thomsen

  2. Clinic for Radiotherapy, University Hospital Erlangen, Erlangen, Germany

    Stefan Bauchowitz, Oliver Ott, Rolf Sauer & Manfred Schmidt

  3. Department of Radiation Oncology, Academic Medical Center (AMC), Amsterdam, The Netherlands

    Hans Crezee

  4. Department of Radiation Oncology, University Medical Center Mannheim, Mannheim, Germany

    Michael Ehmann

  5. Formerly Radiotherapy Charité University Clinic, Berlin, Germany

    Johanna Gellermann

  6. Hospital for Radiation Oncology, University Hospital of Tübingen, Tübingen, Germany

    Ulf Lamprecht

  7. Medical Clinic III, University Clinic Munich, Munich, Germany

    Sultan Abdel-Rahman

  8. Clinic of Pediatric Hematology, Oncology and Clinical Immunology, University Hospital of Düsseldorf, Düsseldorf, Germany

    Rüdiger Wessalowski

  9. Clinic for Radiation Oncology, Cantonal Hospital Aarau, Aarau, Switzerland

    Richard Canters & Nicoletta Lomax

  10. Department of Radiation Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands

    Gerard van Rhoon

  11. Klinik für Strahlenheilkunde Universitätsklinkum Freiburg, Robert-Koch-Straße 3, 79106, Freiburg, Germany

    Gregor Bruggmoser

Authors
  1. Gregor Bruggmoser
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  2. Stefan Bauchowitz
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  3. Richard Canters
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  4. Hans Crezee
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  9. Marc Benjamin Messmer
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  10. Oliver Ott
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  11. Sultan Abdel-Rahman
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  12. Rolf Sauer
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  13. Manfred Schmidt
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  14. Andreas Thomsen
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  15. Rüdiger Wessalowski
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  16. Gerard van Rhoon
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Corresponding author

Correspondence to Gregor Bruggmoser.

Additional information

*The authors of this document are also members of the ESHO Technical Committee.

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Bruggmoser, G., Bauchowitz, S., Canters, R. et al. Quality assurance for clinical studies in regional deep hyperthermia. Strahlenther Onkol 187, 605–610 (2011). https://doi.org/10.1007/s00066-011-1145-x

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  • DOI: https://doi.org/10.1007/s00066-011-1145-x

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