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Sepsisdiagnostik und Antibiotikasteuerung

Diagnosis of sepsis and guidance of antibiotic therapy

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Zusammenfassung

Biomarker werden in der modernen Intensivmedizin weit verbreitet eingesetzt. Dabei ist die Frage nach dem Nutzen für das Outcome der Patienten nicht immer gut untersucht. Im folgenden Artikel werden einzelne Biomarker zu den Fragen der Infektionsdiagnostik und Steuerung der Antibiotikatherapie im Rahmen eines Antibiotic-Stewardship-Programms (ABS) besprochen. Als Infektionsmarker hat sich insbesondere das Prokalzitonin (PCT) bewährt. Es gelingt mit dem PCT besser als mit anderen Markern, zwischen Inflammation und Infektion zu differenzieren. Auch im Kontext von ABS-Visiten ist das PCT gut etabliert.

Abstract

There is a widespread use of biomarkers in modern intensive care. The potential benefit for the patients is, however, not fully investigated. This paper will discuss biomarkers regarding the diagnosis of infections and their potential use in antibiotic stewardship programs (ABS) in order to guide antimicrobial therapy. In the field of infections, procalcitonin (PCT) seems to be the most widespread marker. PCT is able to differentiate between inflammation and infection. Also, in the context of ABS rounds, PCT is well established.

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  1. Klinik für Notfall- und Intensivmedizin, Klinikum Ernst von Bergmann, Charlottenstraße 72, 14467, Potsdam, Deutschland

    M. Oppert

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M. Oppert gibt an, Vortraghonorare und Beraterhonorare von Brahms/Thermofisher erhalten zu haben.

Für diesen Beitrag wurden vom Autor keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

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M. Möckel, Berlin

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Oppert, M. Sepsisdiagnostik und Antibiotikasteuerung. Med Klin Intensivmed Notfmed 114, 286–289 (2019). https://doi.org/10.1007/s00063-019-0570-y

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