Skip to main content
Log in

Technisches Rüstzeug für chronisch verschlossene Gefäße

Technical armamentarium for chronic total occlusion of coronary vessels

  • Schwerpunkt
  • Published:
Herz Aims and scope Submit manuscript

Zusammenfassung

Die perkutane Revaskularisation von chronisch verschlossenen Koronarien stellt seit jeher eine große Herausforderung für die interventionelle Kardiologie dar. In den letzten Jahrzenten wurde eine Vielzahl an Anstrengungen unternommen, um die Revaskularisationsstrategien für chronisch verschlossene Koronarien zu standardisieren. Diese Bestrebungen sind v. a. in dem steigenden Interesse der verschiedenen kardiologischen Fachgesellschaften an dieser Patientengruppe, in der zunehmenden Erfahrung der Interventionalisten und in der fortwährenden Entwicklung des technischen Instrumentariums und von endovaskulären Unterstützungstechnologien begründet. Diese Übersichtsarbeit beleuchtet die aktuell zur Verfügung stehenden Hilfsmittel sowie Technologien, Techniken und Strategien zur perkutanen Rekanalisation von chronisch verschlossenen Koronarien.

Abstract

Percutaneous revascularization of chronic total occlusion (CTO) of coronary vessels represents a major challenge for contemporary interventional cardiologists. In the last decade there has been an unprecedented effort towards the standardization of revascularization procedures for CTO of coronary vessels. This endeavour has been possible by virtue of the growing interest of various cardiological societies for this patient group. Along with supportive endovascular technologies and percutaneous devices specifically dedicated to this interventional target, the increasing experience of interventionalists enabled continuously growing success for revascularization of CTO of coronary vessels. This review article highlights the currently available tools as well as technologies, techniques and strategies for the percutaneous recanalization of CTO of coronary vessels.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2

Literatur

  1. Ybarra LF et al (2021) Definitions and clinical trial design principles for coronary artery chronic total occlusion therapies: CTO-ARC consensus recommendations. Circulation 143(5):479–500

    Article  PubMed  Google Scholar 

  2. Fefer P et al (2012) Current perspectives on coronary chronic total occlusions: the Canadian multicenter chronic total occlusions registry. J Am Coll Cardiol 59(11):991–997

    Article  PubMed  Google Scholar 

  3. Azzalini L et al (2016) Epidemiology, management strategies, and outcomes of patients with chronic total coronary occlusion. Am J Cardiol 118(8):1128–1135

    Article  PubMed  Google Scholar 

  4. Sachdeva R et al (2014) The myocardium supplied by a chronic total occlusion is a persistently ischemic zone. Catheter Cardiovasc Interv 83(1):9–16

    Article  PubMed  Google Scholar 

  5. Werner GS et al (2009) Chronic total coronary occlusions in patients with stable angina pectoris: impact on therapy and outcome in present day clinical practice. Clin Res Cardiol 98(7):435–441

    Article  PubMed  Google Scholar 

  6. Jang WJ et al (2015) Long-term survival benefit of revascularization compared with medical therapy in patients with coronary chronic total occlusion and well-developed collateral circulation. JACC Cardiovasc Interv 8(2):271–279

    Article  PubMed  Google Scholar 

  7. Khan MF et al (2013) Effects of percutaneous revascularization of chronic total occlusions on clinical outcomes: a meta-analysis comparing successful versus failed percutaneous intervention for chronic total occlusion. Catheter Cardiovasc Interv 82(1):95–107

    Article  PubMed  Google Scholar 

  8. Christakopoulos GE et al (2015) Meta-analysis of clinical outcomes of patients who underwent percutaneous coronary interventions for chronic total occlusions. Am J Cardiol 115(10):1367–1375

    Article  PubMed  Google Scholar 

  9. Patel VG et al (2013) Angiographic success and procedural complications in patients undergoing percutaneous coronary chronic total occlusion interventions: a weighted meta-analysis of 18,061 patients from 65 studies. JACC Cardiovasc Interv 6(2):128–136

    Article  PubMed  Google Scholar 

  10. Mares A, Mukherjee D (2021) Management of chronic total occlusion of coronary artery. Int J Angiol 30(1):48–52

    Article  PubMed  Google Scholar 

  11. Lee PH et al (2016) Successful recanalization of native coronary chronic total occlusion is not associated with improved long-term survival. JACC Cardiovasc Interv 9(6):530–538

    Article  PubMed  Google Scholar 

  12. Werner GS et al (2018) A randomized multicentre trial to compare revascularization with optimal medical therapy for the treatment of chronic total coronary occlusions. Eur Heart J 39(26):2484–2493

    Article  CAS  PubMed  Google Scholar 

  13. Obedinskiy AA et al (2018) The IMPACTOR-CTO trial. JACC Cardiovasc Interv 11(13):1309–1311

    Article  PubMed  Google Scholar 

  14. Lee SW et al (2019) Randomized trial evaluating percutaneous coronary intervention for the treatment of chronic total occlusion. Circulation 139(14):1674–1683

    Article  PubMed  Google Scholar 

  15. Mashayekhi K et al (2018) A randomized trial to assess regional left ventricular function after stent implantation in chronic total occlusion: the REVASC trial. JACC Cardiovasc Interv 11(19):1982–1991

    Article  PubMed  Google Scholar 

  16. Galassi AR et al (2011) In-hospital outcomes of percutaneous coronary intervention in patients with chronic total occlusion: insights from the ERCTO (European registry of chronic total occlusion) registry. EuroIntervention 7(4):472–479

    Article  PubMed  Google Scholar 

  17. Maeremans J et al (2016) The hybrid algorithm for treating chronic total occlusions in europe: the RECHARGE registry. J Am Coll Cardiol 68(18):1958–1970

    Article  PubMed  Google Scholar 

  18. Galassi AR et al (2019) Percutaneous recanalisation of chronic total occlusions: 2019 consensus document from the EuroCTO club. EuroIntervention 15(2):198–208

    Article  PubMed  Google Scholar 

  19. Bakker EJ et al (2017) Fully transradial versus transfemoral approach for percutaneous intervention of coronary chronic total occlusions applying the hybrid algorithm: insights from RECHARGE registry. Circ Cardiovasc Interv 10(9):e5255

    Article  PubMed  Google Scholar 

  20. Meijers TA et al (2021) Randomized comparison between radial and femoral large-bore access for complex percutaneous coronary intervention. JACC Cardiovasc Interv 14(12):1293–1303. https://doi.org/10.1016/j.jcin.2021.03.041

    Article  PubMed  Google Scholar 

  21. Soud M et al (2020) The efficacy and safety of transradial and transfemoral approach in treatment of coronary chronic total occlusion: a systematic review and meta-analysis. Expert Rev Cardiovasc Ther 18(11):809–817

    Article  CAS  PubMed  Google Scholar 

  22. Brilakis E (2012) S et al A percutaneous treatment algorithm for crossing coronary chronic total occlusions. JACC Cardiovasc Interv 5(4):367–379

    Article  PubMed  Google Scholar 

  23. Karatasakis A et al (2017) Guidewire and microcatheter utilization patterns during antegrade wire escalation in chronic total occlusion percutaneous coronary intervention: Insights from a contemporary multicenter registry. Catheter Cardiovasc Interv 89(4):E90–e98

    Article  PubMed  Google Scholar 

  24. Maeremans J et al (2016) Antegrade wire escalation for chronic total occlusions in coronary arteries: simple algorithms as a key to success. J Cardiovasc Med (Hagerstown) 17(9):680–686

    Article  Google Scholar 

  25. Walsh SJ et al (2020) Intravascular healing is not affected by approaches in contemporary CTO PCI: the CONSISTENT CTO study. JACC Cardiovasc Interv 13(12):1448–1457

    Article  PubMed  Google Scholar 

  26. Song L et al (2017) Intravascular ultrasound analysis of Intraplaque versus subintimal tracking in percutaneous intervention for coronary chronic total occlusions and association with procedural outcomes. JACC Cardiovasc Interv 10(10):1011–1021

    Article  PubMed  PubMed Central  Google Scholar 

  27. Sumitsuji S et al (2011) Fundamental wire technique and current standard strategy of percutaneous intervention for chronic total occlusion with histopathological insights. JACC Cardiovasc Interv 4(9):941–951

    Article  PubMed  Google Scholar 

  28. Wu EB et al (2019) Chronic total occlusion wiring: a state-of-the-art guide from the asia pacific chronic total occlusion club. Heart Lung Circ 28(10):1490–1500

    Article  PubMed  Google Scholar 

  29. Wilson WM et al (2016) Hybrid approach improves success of chronic total occlusion angioplasty. Heart 102(18):1486–1493

    Article  CAS  PubMed  Google Scholar 

  30. Maeremans J et al (2017) Antegrade dissection and reentry as part of the hybrid chronic total occlusion revascularization strategy. Circ Cardiovasc Interv 10(6):e4791

    Article  PubMed  Google Scholar 

  31. McEntegart MB et al (2016) The collateral circulation of coronary chronic total occlusions. EuroIntervention 11(14):e1596–603

    Article  PubMed  Google Scholar 

  32. Whitlow PL et al (2012) Use of a novel crossing and re-entry system in coronary chronic total occlusions that have failed standard crossing techniques: results of the FAST-CTos (facilitated antegrade steering technique in chronic total occlusions) trial. JACC Cardiovasc Interv 5(4):393–401

    Article  PubMed  Google Scholar 

  33. Sakakura K et al (2014) Comparison of pathology of chronic total occlusion with and without coronary artery bypass graft. Eur Heart J 35(25):1683–1693

    Article  PubMed  Google Scholar 

  34. Tajti P et al (2018) The hybrid approach to chronic total occlusion percutaneous coronary intervention: update from the PROGRESS CTO registry. JACC Cardiovasc Interv 11(14):1325–1335

    Article  PubMed  Google Scholar 

  35. Khand A et al (2015) Retrograde wiring of collateral channels of the heart in chronic total occlusions: a systematic review and meta-analysis of safety, feasibility, and incremental value in achieving revascularization. Angiology 66(10):925–932

    Article  CAS  PubMed  Google Scholar 

  36. Joyal D et al (2012) The retrograde technique for recanalization of chronic total occlusions: a step-by-step approach. JACC Cardiovasc Interv 5(1):1–11

    Article  PubMed  Google Scholar 

  37. Kovacic JC et al (2013) GuideLiner mother-and-child guide catheter extension: a simple adjunctive tool in PCI for balloon uncrossable chronic total occlusions. J Interv Cardiol 26(4):343–350

    Article  PubMed  Google Scholar 

  38. Mashayekhi K et al (2017) Wire externalisation techniques for retrograde percutaneous coronary interventions of chronic total occlusions. EuroIntervention 13(12):e1489–e1490

    Article  PubMed  Google Scholar 

  39. Azzalini L et al (2018) Intracoronary snaring of the retrograde guidewire: how to overcome extreme takeoff angles in chronic total occlusion percutaneous coronary intervention. Catheter Cardiovasc Interv 91(3):464–469

    Article  PubMed  Google Scholar 

  40. Hsu JT et al (2009) Traditional antegrade approach versus combined antegrade and retrograde approach in the percutaneous treatment of coronary chronic total occlusions. Catheter Cardiovasc Interv 74(4):555–563

    Article  PubMed  Google Scholar 

  41. Vemmou E et al (2019) Recent advances in microcatheter technology for the treatment of chronic total occlusions. Expert Rev Med Devices 16(4):267–273

    Article  CAS  PubMed  Google Scholar 

  42. Mohandes M et al (2016) Efficacy and safety of tornus catheter in percutaneous coronary intervention of hard or balloon-uncrossable chronic total occlusion. ARYA Atheroscler 12(4):206–211

    PubMed  PubMed Central  Google Scholar 

  43. Danek BA et al (2017) Incidence, treatment, and outcomes of coronary perforation during chronic total occlusion percutaneous coronary intervention. Am J Cardiol 120(8):1285–1292

    Article  PubMed  Google Scholar 

  44. Ellis SG et al (1994) Increased coronary perforation in the new device era. Incidence, classification, management, and outcome. Circulation 90(6):2725–2730

    Article  CAS  PubMed  Google Scholar 

  45. Shimony A et al (2011) Coronary artery perforation during percutaneous coronary intervention: a systematic review and meta-analysis. Can J Cardiol 27(6):843–850

    Article  PubMed  Google Scholar 

  46. Wu K et al (2019) Predictors, treatment, and long-term outcomes of coronary perforation during retrograde percutaneous coronary intervention via epicardial collaterals for recanalization of chronic coronary total occlusion. Catheter Cardiovasc Interv 93(S1):800–809

    Article  PubMed  Google Scholar 

  47. Kinnaird T et al (2016) Incidence, determinants, and outcomes of coronary perforation during percutaneous coronary intervention in the United Kingdom between 2006 and 2013: an analysis of 527 121 cases from the British cardiovascular intervention society database. Circ Cardiovasc Interv 9(8):e3449. https://doi.org/10.1161/CIRCINTERVENTIONS.115.003449

    Article  PubMed  Google Scholar 

  48. Xenogiannis I, Brilakis ES (2019) Advances in the treatment of coronary perforations. Catheter Cardiovasc Interv 93(5):921–922

    Article  PubMed  Google Scholar 

  49. Witzke CF et al (2004) The changing pattern of coronary perforation during percutaneous coronary intervention in the new device era. J Invasive Cardiol 16(6):257–301

    PubMed  Google Scholar 

  50. Teis A et al (2010) Coronary artery perforation by intracoronary guide wires: risk factors and clinical outcomes. Rev Esp Cardiol 63(6):730–734

    PubMed  Google Scholar 

  51. Werner GS, Ahmed WH (2017) Fenestration of a papyrus PK covered stent to recover the occluded left main bifurcation after sealing a left main perforation during a CTO procedure. Cardiovasc Revasc Med 18(6s1):41–44

    Article  PubMed  Google Scholar 

  52. Moriyama N, Tanaka Y, Saito S (2017) Bailout polytetrafluoroethylene-covered stent implantation for left main bifurcation perforation using the kissing stent technique. Catheter Cardiovasc Interv 89(6):1022–1027

    Article  PubMed  Google Scholar 

  53. Kufner S et al (2019) Outcome after new generation single-layer polytetrafluoroethylene-covered stent implantation for the treatment of coronary artery perforation. Catheter Cardiovasc Interv 93(5):912–920

    Article  PubMed  Google Scholar 

  54. Giannini F et al (2018) A practical approach to the management of complications during percutaneous coronary intervention. JACC Cardiovasc Interv 11(18):1797–1810

    Article  PubMed  Google Scholar 

  55. Garbo R, Oreglia JA, Gasparini GL (2017) The balloon-microcatheter technique for treatment of coronary artery perforations. Catheter Cardiovasc Interv 89(2):E75–e83

    Article  PubMed  Google Scholar 

  56. Milasinovic D et al (2018) Step-by-step manual for planning and performing bifurcation PCI: a resource-tailored approach. EuroIntervention 13(15):e1804–e1811

    Article  PubMed  Google Scholar 

  57. Yu CW et al (2017) Coronary computed tomography angiography predicts guidewire crossing and success of percutaneous intervention for chronic total occlusion: Korean multicenter CTO CT registry score as a tool for assessing difficulty in chronic total occlusion percutaneous coronary intervention. Circ Cardiovasc Imaging 10(4):e5800

    Article  PubMed  Google Scholar 

  58. Tian NL et al (2015) Angiographic and clinical comparisons of intravascular ultrasound- versus angiography-guided drug-eluting stent implantation for patients with chronic total occlusion lesions: two-year results from a randomised AIR-CTO study. EuroIntervention 10(12):1409–1417

    Article  PubMed  Google Scholar 

  59. Kim BK et al (2015) Clinical impact of intravascular ultrasound-guided chronic total occlusion intervention with zotarolimus-eluting versus biolimus-eluting stent implantation: randomized study. Circ Cardiovasc Interv 8(7):e2592

    Article  PubMed  CAS  Google Scholar 

  60. Galassi AR et al (2016) Utility of intravascular ultrasound in percutaneous revascularization of chronic total occlusions: an overview. JACC Cardiovasc Interv 9(19):1979–1991

    Article  PubMed  Google Scholar 

  61. Xhepa E et al (2019) Subintimal versus intraplaque recanalization of coronary chronic total occlusions: mid-term angiographic and OCT findings from the ISAR-OCT-CTO registry. JACC Cardiovasc Interv 12(19):1889–1898

    Article  PubMed  Google Scholar 

  62. Xhepa E et al (2021) Clinical and angiographic outcomes of crossing techniques for coronary chronic total occlusions—the ISAR-CTO registry. EuroIntervention. https://doi.org/10.4244/EIJ-D-20-01248

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to S. Cassese MD, PhD.

Ethics declarations

Interessenkonflikt

F. Voll, C. Kuna, S. Kufner und S. Cassese geben an, dass kein Interessenkonflikt besteht.

Für diesen Beitrag wurden von den Autoren keine Studien an Menschen oder Tieren durchgeführt. Für die aufgeführten Studien gelten die jeweils dort angegebenen ethischen Richtlinien.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Voll, F., Kuna, C., Kufner, S. et al. Technisches Rüstzeug für chronisch verschlossene Gefäße. Herz 46, 406–418 (2021). https://doi.org/10.1007/s00059-021-05053-y

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00059-021-05053-y

Schlüsselwörter

Keywords

Navigation