Skip to main content
SpringerLink
Log in

The right atrium in idiopathic hypereosinophilic syndrome

Insights from the 3D speckle tracking echocardiographic MAGYAR-Path Study

Der rechte Vorhof beim idiopathischen hypereosinophilen Syndrom

Erkenntnisse aus der 3‑D-Speckle-Tracking-Echokardiogaphie-MAGYAR-Path-Studie

  • Original articles
  • Published:
Herz Aims and scope Submit manuscript

Abstract

Background

Idiopathic hypereosinophilic syndrome is characterized by a persistent eosinophil blood count of >1.5 × 109 cells/l and organ damage, independent of the primary and secondary causes of eosinophilia. The purpose of the present study was to assess the three-dimensional speckle tracking echocardiography-derived right atrial volumetric and functional properties between hypereosinophilic syndrome patients and matched controls.

Methods

A total of 11 patients with idiopathic hypereosinophilic syndrome and 22 age- and gender-matched healthy controls were enrolled in the study. Three-dimensional speckle tracking echocardiography was used for calculation of right atrial volumes, volume-based functional properties, and strain parameters.

Results

Significantly increased right atrial maximum (68.7 ± 33.1 ml vs. 40.3 ± 12.1 ml, respectively; p = 0.001) and minimum volumes (48.3 ± 31.0 ml vs. 28.3 ± 9.4 ml, respectively; p = 0.009), as well as right atrial volume before atrial contraction (58.6 ± 27.3 ml vs. 34.5 ± 11.8 ml, respectively; p = 0.001), were found in hypereosinophilic syndrome patients compared with controls. Total and passive right atrial stroke volumes proved to be significantly increased in hypereosinophilic syndrome patients. However, global and mean segmental strain parameters did not differ significantly between the groups.

Conclusion

Increased cyclic right atrial volumes and mild alterations in right atrial functional properties could be demonstrated in idiopathic hypereosinophilic syndrome patients.

Zusammenfassung

Hintergrund

Das idiopathische hypereosinophile Syndrom ist gekennzeichnet durch eine persistierende Eosinophilenzahl im Blut >1,5 × 109 Zellen/l und Organschäden, unabhängig von den primären und sekundären Ursachen der Eosinophilie. Ziel der vorliegenden Studie war es, die in der 3‑D-Speckle-Tracking-Echokardiographie ermittelten volumetrischen und funktionellen Eigenschaften des rechten Vorhofs zwischen Patienten mit hypereosinophilem Syndrom und entsprechenden Kontrollen zu vergleichen.

Methoden

Insgesamt wurden 11 Patienten mit idiopathischem hypereosinophilem Syndrom und 22 in Alter und Geschlecht entsprechend ausgewählte gesunde Kontrollen in die Studie aufgenommen. Die 3‑D-Speckle-Tracking-Echokardiographie wurde für die Ermittlung rechtsatrialer Volumina, volumenbasierter funktioneller Eigenschaften und von Dehnungsparametern eingesetzt.

Ergebnisse

Eine signifikante Erhöhung der rechtsatrialen Maximal- (68,7 ± 33,1 ml vs. 40,3 ± 12,1 ml; p = 0,001) und Minimalvolumina (48,3 ± 31,0 ml vs. 28,3 ± 9,4 ml; p = 0,009) sowie der rechtsatrialen Volumina vor der Vorhofkontraktion (58,6 ± 27,3 ml vs. 34,5 ± 11,8 ml; p = 0,001) wurde bei Patienten mit hypereosinophilem Syndrom im Vergleich zu Kontrollen festgestellt. Die Gesamt- und die passiven rechtsatrialen Schlagvolumina erwiesen sich bei Patienten mit hypereosinophilem Syndrom als signifikant erhöht. Die globalen und durchschnittlichen segmentalen Deformationsparameter unterschieden sich nicht signifikant zwischen den Gruppen.

Schlussfolgerung

Erhöhte zyklische rechtsatriale Volumina und leichte Veränderungen der rechtsatrialen funktionellen Eigenschaften waren bei Patienten mit idiopathischem hypereosinophilem Syndrom nachweisbar.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Gotlib J (2014) World Health Organization-defined eosinophilic disorders: 2014 update on diagnosis, risk stratification, and management. Am J Hematol 89:325–337

    Article  CAS  PubMed  Google Scholar 

  2. Weller PF, Bubley GJ (1994) The idiopathic hypereosinophilic syndrome. Blood 83:2759–2579

    CAS  PubMed  Google Scholar 

  3. Curtis C, Ogbogu P (2016) Hypereosinophilic syndrome. Clin Rev Allergy Immunol 50:240–251

    Article  CAS  PubMed  Google Scholar 

  4. Chusid MJ, Dale DC, West BC, Wolff SM (1975) The hypereosinophilic syndrome: analysis of fourteen cases with review of the literature. Medicine (Baltimore) 54:1–27

    Article  CAS  Google Scholar 

  5. Mankad R, Bonnichsen C, Mankad S (2016) Hypereosinophilic syndrome: cardiac diagnosis and management. Heart 102:100–106

    Article  CAS  PubMed  Google Scholar 

  6. Kleinfeldt T, Nienaber CA, Kische S, Akin I, Turan RG, Körber T, Schneider H, Ince H (2010) Cardiac manifestation of the hypereosinophilic syndrome: new insights. Clin Res Cardiol 99:419–427

    Article  CAS  PubMed  Google Scholar 

  7. Yamamoto T, Tanaka H, Kurimoto C, Imanishi T, Hayashi N, Saegusa J, Morinobu A, Hirata KI, Kawano S (2016) Very early stage left ventricular endocardial dysfunction of patients with hypereosinophilic syndrome. Int J Cardiovasc Imaging 32:1357–1361

    Article  PubMed  Google Scholar 

  8. Nemes A, Marton I, Domsik P, Kalapos A, Pósfai É, Modok S, Borbényi Z, Forster T (2016) Characterization of left atrial dysfunction in hypereosinophilic syndrome – Insights from the Motion analysis of the heart and great vessels by three-dimensional speckle tracking echocardiography in pathological cases (MAGYAR-Path) Study. Rev Port Cardiol 35:277–283

    Article  PubMed  Google Scholar 

  9. Nemes A, Kalapos A, Domsik P, Forster T (2012) Three-dimensional speckle-tracking echocardiography – a further step in non-invasive three-dimensional cardiac imaging. Orv Hetil 153:1570–1577

    Article  PubMed  Google Scholar 

  10. Nemes A, Domsik P, Kalapos A, Gavallér H, Oszlánczi M, Forster T (2016) Right atrial deformation analysis in isolated left ventricular noncompaction – insights from the three-dimensional speckle tracking echocardiographic MAGYAR-Path Study. Rev Port Cardiol 35:515–521

    Article  PubMed  Google Scholar 

  11. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, Flachskampf FA, Foster E, Goldstein SA, Kuznetsova T, Lancellotti P, Muraru D, Picard MH, Rietzschel ER, Rudski L, Spencer KT, Tsang W, Voigt JU (2015) Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J Am Soc Echocardiogr 28:1–39.e14

    Article  PubMed  Google Scholar 

  12. Kim NK, Kim CY, Kim JH, Jang SY, Bae MH, Lee JH, Yang DH, Park HS, Cho Y, Chae SC (2015) A hypereosinophilic syndrome with cardiac involvement from thrombotic stage to fibrotic stage. J Cardiovasc Ultrasound 23:100–102

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Shah R, Ananthasubramaniam K (2006) Evaluation of cardiac involvement in hypereosinophilic syndrome: complementary roles of transthoracic, transesophageal, and contrast echocardiography. Echocardiography 23:689–691

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We acknowledge Ms. Zsuzsanna Horváth for the data management in this study.

Author information

Authors and Affiliations

  1. 2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Semmelweis Street 8, P.O. Box 427, 6725, Szeged, Hungary

    A. Nemes MD, PhD, DSc, FESC, P. Domsik, A. Kalapos, Á. Kormányos, N. Ambrus & T. Forster

  2. Division of Haematology, 2nd Department of Medicine and Cardiology Centre, Medical Faculty, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary

    I. Marton, É. Pósfai, S. Modok & Z. Borbényi

Authors
  1. A. Nemes MD, PhD, DSc, FESC
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. Marton
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. P. Domsik
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. Kalapos
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. É. Pósfai
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. S. Modok
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Á. Kormányos
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. N. Ambrus
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Z. Borbényi
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. T. Forster
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. Nemes MD, PhD, DSc, FESC.

Ethics declarations

Conflict of interest

A. Nemes, I. Marton, P. Domsik, A. Kalapos, É. Pósfai, S. Modok, Á. Kormányos, N. Ambrus, Z. Borbényi, and T. Forster declare that they have no competing interests.

The study protocol conformed to the ethical guidelines of the 1975 Declaration of Helsinki (and updated versions) and was approved in advance by the local institutional ethics committee. Informed consent was obtained from each subject.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nemes, A., Marton, I., Domsik, P. et al. The right atrium in idiopathic hypereosinophilic syndrome. Herz 44, 405–411 (2019). https://doi.org/10.1007/s00059-017-4652-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00059-017-4652-4

Keywords

Schlüsselwörter

Search

Navigation