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Diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs

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Abstract

Kojic acid (KA) is a natural product containing 3-hydroxy-4-pyranone scaffold. It is produced by various aerobic microorganisms such as Aspergillus and Penicillium species. Since this bioactive compound can inhibit tyrosinase enzyme, it has been mainly used as a whitening agent in cosmetics. KA is a polyfunctional heterocycle providing a potential intermediate for the design and synthesis of new biologically active compounds. Numerous studies demonstrated that KA-derived compounds have significant antibacterial, antifungal, anticancer, anticonvulsant, anti-Alzheimer’s disease and metal chelating activities. In this review, we have described diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs.

Modification of the natural product kojic acid has been considered for new lead generation with diverse biological activities.

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Acknowledgements

The authors are grateful to Mazandaran University of Medical Sciences for financial support (grant No. 5396).

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  1. Department of Medicinal Chemistry and Pharmaceutical Sciences Research Center, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran

    Saeed Emami, Reza Ahmadi, Hamideh Ahadi & Morteza Ashooriha

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Emami, S., Ahmadi, R., Ahadi, H. et al. Diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs. Med Chem Res 31, 1842–1861 (2022). https://doi.org/10.1007/s00044-022-02954-3

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