Abstract
Maytenus is a genus in the plant family Celastraceae, the species of which are primarily distributed in China, Brazil, Uruguay, Paraguay, and northern Argentina. These plants have long been used as a resource for the development of medicines. The latest advances in the pharmacology and phytochemistry of Maytenus are reviewed in this paper. Studies have discovered that Maytenus spieces have efficacy in the treatment of various diseases. They are widely used as antitumor, anti-septicaemia, anti-inflammatory, analgesic, antibacterial, antioxidative, antiulcer, antipathogenic, anti-proliferative and salivation-inducing drugs. In addition, they are used for treating asthma, digestive tract diseases, rheumatism, and rheumatoid diseases. Recently, there has been growing interest in the medicinal value of Maytenus. The diversity of the biological and pharmacological activities attributed to Maytenus is associated with the presence of a large number of chemical substances in these species, the most important of which are triterpenes, sesquiterpenes, and alkaloids. Among these, certain triterpenes have been demonstrated to be effective anticancer agents. In this paper, we present an overview of the phytochemicals in species within the Maytenus genus and their associated biological activities, which can provide a reference for future research, development, and utilisation of these species.
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Abbreviations
- 7,12-dimethylbenz [α] anthracene:
-
(DMBA)
- 12-O-tetradecanoylphorbol-13-acetate:
-
(TPA)
- Alanine aminotransferase:
-
(ALT)
- 30-hydroxy-11α-methoxy-18β-olean-12-en-3-one:
-
(HMO)
- Reactive oxygen species:
-
(ROS)
- Minimum inhibitory concentration:
-
(MIC)
- Aqueous ethanol soluble fraction:
-
(AESF)
- Soluble fraction:
-
(SF)
- Mouse macrophages:
-
(RAW 264.7)
- Leaves of M. procumbens :
-
(LMP)
- Determination of oxygen radical absorption rate:
-
(ORAC)
- Minimum inhibitory concentration:
-
(MIC)
- Liver hepatocellular cells:
-
(HepG2)
- Colon cancer cell:
-
(HT-29)
- Spray-dried extract of M. ilicifolia :
-
(SDEMI)
- Activity of protein kinase B:
-
(AKT)
- Extracellular signal-regulated kinases:
-
(ERK)
- Mammalian target of rapamycin:
-
(mTOR)
- Vascular endothelial growth factor:
-
(VEGF)
- Vascular endothelial growth factor receptor 2:
-
(VEGFR2)
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Acknowledgements
The authors would like to thank LZ, M-YJ, BQ, QYL, K-YZ, J-CL, L-SD and M-HL for thoughtful discussions and critical review of the manuscript. This work was supported by the National Natural Science Foundation of China (M1942003) and 2018 Chinese medicine public health service subsidy special “national Chinese medicine resources census project”.
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Zhang, L., Ji, MY., Bin Qiu et al. Phytochemicals and biological activities of species from the genus Maytenus. Med Chem Res 29, 575–606 (2020). https://doi.org/10.1007/s00044-020-02509-4
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DOI: https://doi.org/10.1007/s00044-020-02509-4