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Preparation and biological evaluation of quinoline amines as anticancer agents and its molecular docking

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Abstract

A series of 2-chloro N-substituted amino quinolines (2a–2j) were prepared and characterized by analytical and spectroscopic methods. As quinoline is an important pharmacophoric moiety, the prepared compounds were screened against a non-small cell lung cancer cell line, A549. One of the compounds, 2-chloro-8-methyl-N-(quinolin-5-yl)quinolin-4-amine (2b) is found to be active with inhibition concentration value of (IC50) 29.4 μM. The molecular docking studies with the predominant PI3K/AKT/mTOR pathway proteins also revealed the lesser binding energy with 2b. All the compounds are predicted to satisfy the ADME profile and the results let us to consider 2b as a lead compound for new generation of A549 cell line inhibitors and for further studies in this way.

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Acknowledgements

The authors are highly thankful to the Department of Science and Technology, New Delhi for financial support under WOS-A Scheme (SR/WOS-A/CS-1084/2014). KNV acknowledges the computational facility and Schrodinger access offered by Prof. D. Velmurugan, BSR Faculty, Center for crystallography and Biophysics, University of Madras, Chennai.

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Correspondence to Kuppannagounder P. Elango.

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Vennila, K.N., Prabha, K., Sunny, D. et al. Preparation and biological evaluation of quinoline amines as anticancer agents and its molecular docking. Med Chem Res 28, 1298–1307 (2019). https://doi.org/10.1007/s00044-019-02374-w

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  • DOI: https://doi.org/10.1007/s00044-019-02374-w

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