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Synthesis of NSAIDs–Se derivatives as potent anticancer agents

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Abstract

In the present study, a series of NSAIDs–Se derivatives include selenocyanates and diselenides were synthesized and characterized, their anticancer activities against the human cancer cell lines SW480, HeLa, A549, and HepG2 were determined. Interestingly, most of the new compounds showed active in reducing the viability of different cancer lines. Compounds 1a and 1m exhibited higher promising activities than other derivatives. As the most active compound 1a showed IC50 values lower than 20 μM against the four cancer cell lines, particularly against SW480 with IC50 values below 10 μm, it shows the potential to be a promising molecular chemotherapeutic agent for colorectal cancer.

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Acknowledgements

This investigation was made possible through the financial support of National Natural Science Foundation of China (Grant No: 21302065).

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Authors and Affiliations

  1. Institute for Interdisciplinary Research, Jianghan University, Wuhan Economic and Technological Development Zone, 430056, Wuhan, People’s Republic of China

    lei Liu, Zhang Yongmin & Xianran He

  2. Shenzhen Fushan Biological Technology Co., Ltd, Kexing Science Park A1 1005, Nanshan Zone, 518057, Shenzhen, People’s Republic of China

    Shaolei Li & Xiaolong Li

  3. Key Laboratory of Optoelectronic Chemical Materials and Devices, Ministry of Education, School of Chemical and Environmental Engineering, Jianghan University, 430056, Wuhan, People’s Republic of China

    Min Zhong & Xianran He

  4. School of Chemical and Environmental Engineering, Jianghan University, Wuhan Economic and Technological Development Zone, 430056, Wuhan, People’s Republic of China

    Min Zhong, Yin Lu & Yang Jiajie

  5. Institut Parisien de Chimie Moléculaire, CNRS UMR 7201, Université Pierre et Marie Curie-Paris 6, 4 Place Jussieu, 75005, Paris, France

    Zhang Yongmin

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  1. lei Liu
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  2. Shaolei Li
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  3. Xiaolong Li
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  4. Min Zhong
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  5. Yin Lu
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  6. Yang Jiajie
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  7. Zhang Yongmin
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  8. Xianran He
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Correspondence to Xianran He.

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We declare that we have no financial and personal relationships with other people or organizations that caninappropriately influence our work, there is no professional or other personal interest of any nature or kind inany product, service and/or company that could be construed as influencing the position presented in, or thereview of, the manuscript entitled “Synthesis of NSAIDs–Se derivatives as potent anticancer agents”.

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Liu, l., Li, S., Li, X. et al. Synthesis of NSAIDs–Se derivatives as potent anticancer agents. Med Chem Res 27, 2071–2078 (2018). https://doi.org/10.1007/s00044-018-2216-7

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  • DOI: https://doi.org/10.1007/s00044-018-2216-7

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