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RETRACTED ARTICLE: Rhodozepinone, a new antitrypanosomal azepino-diindole alkaloid from the marine sponge-derived bacterium Rhodococcus sp. UA13

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This article was retracted on 30 November 2018

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Abstract

A new azepino-diindole alkaloid; rhodozepinone (1), along with five known compounds, including 2-amino-3-[2(1H)-quinolinon-4-yl]propionic acid (2), 3-hydroxy-2-methyl-4H-pyran-4-one (maltol) (3), phenyl acetic acid methyl ester (4), indole-3-acetic acid (5), and 2-amino-3-(1H-indol-3-yl) propanoic acid (tryptophan) (6) were isolated and identified from the broth culture of Rhodococcus sp. UA13, which had been previously recovered from the Red Sea sponge Callyspongia aff. Implexa. The structures of compounds (1–6) were determined by spectroscopic analyses, including 1D and 2D NMR experiments in combination with HR-ESI-MS, as well as comparison with the literature. All the characterized metabolites were firstly reported herein from this marine sponge-associated actinomycete, and among them, (3), (4), and (6) were characterized for the first time from the genus Rhodococcus, whereas this is the first report for isolation of compound (2) from a natural source. Moreover, both the antimicrobial and antitrypanosomal properties of the isolated metabolites (1–6) were evaluated, and only rhodozepinone (1) exhibited significant antibacterial and antitrypanosomal activities against Staphylococcus aureus NCTC 8325 (IC50 = 8.9 µg/ml) and Trypanosoma brucei brucei TC221 [IC50 = 16.3 (48 h) and 11.8 (72 h) µg/ml], respectively. These results totally reflected the potential of sponge-derived actinomycetes as a rich source of new natural products with interesting bioactivities, as well as their promising future contribution to drug discovery.

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Change history

  • 30 November 2018

    The authors have retracted this article due to the inconsistencies between the reported structures of compounds 1 and 2 and their NMR experimental data. All authors agree with this retraction.

  • 30 November 2018

    The authors have retracted this article due to the inconsistencies between the reported structures of compounds 1 and 2 and their NMR experimental data. All authors agree with this retraction.

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Acknowledgements

The authors are grateful to Dr. Matthias Grüne for the NMR data acquisition. Our thanks also to Antje Fuss/ Prof. August Stich (SFB 630 TP Z1, University of Würzburg) for the antimicrobial and antitrypanosomal assays.

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Authors and Affiliations

  1. Department of Pharmacognosy, Faculty of Pharmacy, Minia University, 61519, Minia, Egypt

    Yasmin Elsayed, John Refaat, Usama R. Abdelmohsen & Mostafa A. Fouad

  2. Department of Botany II, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Julius-von-Sachs-Platz 3, 97082, Würzburg, Germany

    Usama R. Abdelmohsen

  3. Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, 41522, Ismailia, Egypt

    Safwat Ahmed

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  1. Yasmin Elsayed
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Correspondence to John Refaat.

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The authors have retracted this article due to the inconsistencies between the reported structures of compounds 1 and 2 and their NMR experimental data. All authors agree with this retraction.

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Elsayed, Y., Refaat, J., Abdelmohsen, U.R. et al. RETRACTED ARTICLE: Rhodozepinone, a new antitrypanosomal azepino-diindole alkaloid from the marine sponge-derived bacterium Rhodococcus sp. UA13. Med Chem Res 26, 2751–2760 (2017). https://doi.org/10.1007/s00044-017-1974-y

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