Abstract
Bioassay-guided fractionation of the marine sponge Lendenfeldia dendyi and the soft coral Sinularia dura resulted in the isolation of five polybrominated diphenyl ethers (1–5). The structures of the isolated compounds were determined using spectroscopic methods (1D and 2D NMR) and HRMS analyses. The absolute structures of compounds 1 and 2 were confirmed by X-ray analysis. Antimicrobial testing of the isolated compounds along with the acetylated derivative of compound 2 (2a) indicated that they displayed a significant and selective activity against methicillin-resistant Staphylococcus aureus (MRSa) with IC50 values of <0.04–1.18 µM. The antimalarial and antileishmanial activities of the isolated compounds were also evaluated.
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Acknowledgments
We are grateful to Dr. Bharathi Avula, Dr. Shabana Khan, Surendra Jain, and Ms. Marsha Wright, National Center for Natural Products Research for assistance with the HRESIMS, cytotoxicity, and antimicrobial assays. The authors also acknowledge the US Department of Agriculture, Agriculture Research Services Specific Cooperation Agreement No. 58-6408-7-012 and the NIH, NIAID, Division of AIDS, Grant No. AI 27094, for partial support of this work.
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Radwan, M.M., Wanas, A.S., Fronczek, F.R. et al. Polybrominated diphenyl ethers from the marine organisms Lendenfeldia dendyi and Sinularia dura with anti-MRSa activity. Med Chem Res 24, 3398–3404 (2015). https://doi.org/10.1007/s00044-015-1386-9
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DOI: https://doi.org/10.1007/s00044-015-1386-9