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Flavonoids as lead compounds modulating the enzyme targets in Alzheimer’s disease

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Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder of the brain amongst the elderly. The various enzyme targets have been identified including cholinesterase (acetylcholinesterase and butyrylcholinesterase), beta secretase, glycogen synthase kinase-3β and NADPH that play an important role in the pathogenesis of AD. Flavonoids are the phytochemicals with wide range of potential therapeutic activities including AD. Naturally occurring flavonoids have been shown to produce the beneficial effects in experimental models of AD through multiple mechanisms. Accordingly, the naturally occurring flavonoids scaffolds have been modified or new flavonoids analogues have been synthesized to obtain effective drugs for AD management. The present review describes the enzyme targets-(of AD) modulating naturally/synthesized flavonoids which may be potentially useful in the management of AD.

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Acknowledgments

The authors duly acknowledge the financial support from UGC New Delhi, India, through the research scheme no. 39-716/2010 (SR).

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  1. Department of Chemistry, Punjabi University, Patiala, 147002, Punjab, India

    Preet Anand & Baldev Singh

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  1. Preet Anand
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  2. Baldev Singh
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Correspondence to Baldev Singh.

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Anand, P., Singh, B. Flavonoids as lead compounds modulating the enzyme targets in Alzheimer’s disease. Med Chem Res 22, 3061–3075 (2013). https://doi.org/10.1007/s00044-012-0353-y

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