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Synthesis and biological activity studies of furan derivatives

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Abstract

The organic compounds, 4-Ethyl-2,5,5-triphenyl-4,5-dihydrofuran-3-carbonitrile; 2,4,5-Triphenyl-5-propyl-4,5-dihydrofuran-3-carbonitrile; 4-Ethyl-5,5-diphenyl-2-thien-2-yl-4,5-dihydrofuran-3-carbonitrile; 2-(1-Benzofuran-2-yl-)-5-propyl-4,5-diphenyl-4,5-dihydrofuran-3-carbonitrile; 4-Ethyl-5,5-diphenyl-4,5-dihydro-2,2’-bifuran-3-carbonitrile, were synthesized and purified through column chromatography and preparative TLC. All compounds were characterized by IR, 1H, 13C NMR, MS, and microanalysis. The in vitro antibacterial and antifungal activities of these compounds were investigated against some bacteria and fungi. The antibacterial and antifungal activities were measured by using the disc-diffusion method against gram-positive bacteria, i.e., Staphylococcus aureus ATCC 25923, Staphylococcus enteritidis ATCC1376, Psydomamonas aeruginosa ATCC 29212, Bacillus subtilis RSKK 244, Bacillus megaterium gram-negative bacteria Escherichia coli ATCC 27853, Listeria monocytogenes ATCC 7644, and as fungus Micrococcus Luteus NRRLB was used. All compounds in this study showed activity against test bacteria. Their antibiogram tests showed better results than some known antibiotics.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Arts and Sciences, Gazi University, 06500, Teknikokullar, Ankara, Turkey

    Elif Loğoğlu & Sercan Mercan

  2. Department of Chemistry, Faculty of Arts and Sciences, Kocaeli University, 41380, Umuttepe, Kocaeli, Turkey

    Mehmet Yilmaz

  3. Department of Biology Education, Faculty of Education, Gazi University, 06500, Teknikokullar, Ankara, Turkey

    Hikmet Katircioğlu

  4. Department of Chemistry, Faculty of Sciences, Ankara University, Tandoğan, Ankara, Turkey

    Mehtap Yakut

Authors
  1. Elif Loğoğlu
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  2. Mehmet Yilmaz
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  3. Hikmet Katircioğlu
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  4. Mehtap Yakut
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  5. Sercan Mercan
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Correspondence to Elif Loğoğlu.

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Loğoğlu, E., Yilmaz, M., Katircioğlu, H. et al. Synthesis and biological activity studies of furan derivatives. Med Chem Res 19, 490–497 (2010). https://doi.org/10.1007/s00044-009-9206-8

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  • DOI: https://doi.org/10.1007/s00044-009-9206-8

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