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Effect of chronic stress on tumorigenesis and development

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Abstract

Chronic stress activates the sympathetic nervous system (SNS) and hypothalamic–pituitary–adrenal (HPA) axis to aggravates tumorigenesis and development. Although the importance of SNS and HPA in maintaining homeostasis has already attracted much attention, there is still a lot remained unknown about the molecular mechanisms by which chronic stress influence the occurrence and development of tumor. While some researches have already concluded the mechanisms underlying the effect of chronic stress on tumor, complicated processes of tumor progression resulted in effects of chronic stress on various stages of tumor remains elusive. In this reviews we concluded recent research progresses of chronic stress and its effects on premalignancy, tumorigenesis and tumor development, we comprehensively summarized the molecular mechanisms in between. And we highlight the available treatments and potential therapies for stressed patients with tumor.

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Acknowledgements

We would like to give our sincere gratitude to the reviewers for their constructive comments.

Funding

This work was supported by the National Natural Science Foundation of China (No: 82073280 to WWH). Seeking Outstanding Youth Program, Lingang Laboratory (No: LG-QS-202205-09 to WWH). The National Key New Drug Innovation Program, the Ministry of Science and Technology of China (No: 2018ZX09201017-006 to YY). New Drug Leading Scholar Program, China Pharmaceutical University (to YY).

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  1. Chen Wang and Yumeng Shen are co-first authors.

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  1. State Key Laboratory of Natural Medicines, Center for New Drug Safety Evaluation and Research, China Pharmaceutical University, No. 639 Long Mian Avenue, Jiangning District, Nanjing, 211198, Jiangsu, People’s Republic of China

    Chen Wang, Yumeng Shen, Jiaping Ni, Weiwei Hu & Yong Yang

  2. Lingang Laboratory, Shanghai, 200032, People’s Republic of China

    Weiwei Hu

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  1. Chen Wang
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CW,YMS and WWH contributed to writing this manuscript, CW and JPN contributed to searching for material. YY and WWH designed this manuscript. All authors listed have made a substantial contribution to the work. All authors have read and approved the article.

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Correspondence to Weiwei Hu or Yong Yang.

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Wang, C., Shen, Y., Ni, J. et al. Effect of chronic stress on tumorigenesis and development. Cell. Mol. Life Sci. 79, 485 (2022). https://doi.org/10.1007/s00018-022-04455-3

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