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Regulation of B-cell function by NF-kappaB c-Rel in health and disease

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Abstract

B cells mediate humoral immune response and contribute to the regulation of cellular immune response. Members of the Nuclear Factor kappaB (NF-κB) family of transcription factors play a major role in regulating B-cell functions. NF-κB subunit c-Rel is predominantly expressed in lymphocytes, and in B cells, it is required for survival, proliferation, and antibody production. Dysregulation of c-Rel expression and activation alters B-cell homeostasis and is associated with B-cell lymphomas and autoimmune pathologies. Based on its essential roles, c-Rel may serve as a potential prognostic and therapeutic target. This review summarizes the current understanding of the multifaceted role of c-Rel in B cells and B-cell diseases.

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Acknowledgements

This work was supported by the National Institute of Health, NIH/NIAID grants R21AI144264 and R01AI116730 to P.R.

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  1. Department of Pathology, School of Medicine, Case Western Reserve University, University Hospitals Cleveland Medical Center, 6526, Wolstein Research Building, 2103 Cornell Road, Cleveland, OH, 44106, USA

    Shrikanth C. Basavarajappa & Parameswaran Ramakrishnan

  2. Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA

    Parameswaran Ramakrishnan

  3. The Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA

    Parameswaran Ramakrishnan

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  1. Shrikanth C. Basavarajappa
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Basavarajappa, S.C., Ramakrishnan, P. Regulation of B-cell function by NF-kappaB c-Rel in health and disease. Cell. Mol. Life Sci. 77, 3325–3340 (2020). https://doi.org/10.1007/s00018-020-03488-w

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