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Mechanisms of collective cell movement lacking a leading or free front edge in vivo

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Abstract

Collective cell movement is one of the strategies for achieving the complex shapes of tissues and organs. In this process, multiple cells within a group held together by cell–cell adhesion acquire mobility and move together in the same direction. In some well-studied models of collective cell movement, the mobility depends strongly on traction generated at the leading edge by cells located at the front. However, recent advances in live-imaging techniques have led to the discovery of other types of collective cell movement lacking a leading edge or even a free edge at the front, in a diverse array of morphological events, including tubule elongation, epithelial sheet extension, and tissue rotation. We herein review some of the developmental events that are organized by collective cell movement and attempt to elucidate the underlying cellular and molecular mechanisms, which include membrane protrusions, guidance cues, cell intercalation, and planer cell polarity, or chirality pathways.

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Acknowledgements

We apologize to colleagues whose work could not be cited because of space limitations. We especially thank all the members of Kuranaga laboratory for valuable discussions. Studies by our group were supported in part by grants from the Takeda Science Foundation (E.K.), the Japan Foundation for Applied Enzymology (E.K.), MEXT KAKENHI Grant Number JP26114003 (E.K.) and the JSPS KAKENHI Grant Numbers JP24687027 (E.K.), and JP16H04800 (E.K.).

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  1. Laboratory for Histogenetic Dynamics, RIKEN Center for Developmental Biology, Kobe, 650-0047, Japan

    Hiroyuki Uechi & Erina Kuranaga

  2. Laboratory of Histogenetic Dynamics, Graduate School of Life Sciences, Tohoku University, Sendai, 980-8578, Japan

    Erina Kuranaga

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  1. Hiroyuki Uechi
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  2. Erina Kuranaga
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Correspondence to Erina Kuranaga.

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Uechi, H., Kuranaga, E. Mechanisms of collective cell movement lacking a leading or free front edge in vivo. Cell. Mol. Life Sci. 74, 2709–2722 (2017). https://doi.org/10.1007/s00018-017-2489-x

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  • DOI: https://doi.org/10.1007/s00018-017-2489-x

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