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Molecular basis of mycobacterial survival in macrophages

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An Author Correction to this article was published on 11 October 2017

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Abstract

Macrophages play an essential role in the immune system by ingesting and degrading invading pathogens, initiating an inflammatory response and instructing adaptive immune cells, and resolving inflammation to restore homeostasis. More interesting is the fact that some bacteria have evolved to use macrophages as a natural habitat and tools of spread in the host, e.g., Mycobacterium tuberculosis (Mtb) and some non-tuberculous mycobacteria (NTM). Mtb is considered one of humanity’s most successful pathogens and is the causal agent of tuberculosis, while NTMs cause opportunistic infections all of which are of significant public health concern. Here, we describe mechanisms by which intracellular pathogens, with an emphasis on mycobacteria, manipulate macrophage functions to circumvent killing and live inside these cells even under considerable immunological pressure. Such macrophage functions include the selective evasion or engagement of pattern recognition receptors, production of cytokines, reactive oxygen and nitrogen species, phagosome maturation, as well as other killing mechanisms like autophagy and cell death. A clear understanding of host responses elicited by a specific pathogen and strategies employed by the microbe to evade or exploit these is of significant importance for the development of effective vaccines and targeted immunotherapy against persistent intracellular infections like tuberculosis.

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  • 11 October 2017

    One of the author affiliations was missed to include in the original publication. The correct information is given below.

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Acknowledgements

This work was supported by funds from the Research Council of Norway through Centres of Excellence Funding Scheme Project 223255/F50 and the Liaison Committee between NTNU and the Central Norway Regional Health Authority to the authors. We thank Dr. Magnus Steigedal, Dr. Markus Haug, and Dr. Jenny Ostrop for valuable feedback on the manuscript.

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  1. Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, PB 8905, 7491, Trondheim, Norway

    Jane Atesoh Awuh & Trude Helen Flo

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  1. Jane Atesoh Awuh
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  2. Trude Helen Flo
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Correspondence to Trude Helen Flo.

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A correction to this article is available online at https://doi.org/10.1007/s00018-017-2683-x.

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Awuh, J.A., Flo, T.H. Molecular basis of mycobacterial survival in macrophages. Cell. Mol. Life Sci. 74, 1625–1648 (2017). https://doi.org/10.1007/s00018-016-2422-8

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