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Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour

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Abstract.

Fibroblast proliferation is a key process in tissue remodeling and mast cells (MCs) are thought to play a crucial role. Having established that the three major MC products, tryptase, histamine and TNF-alpha (TNF) are normally present in human skin MCs, which are in close proximity to dermal fibroblasts, we studied their individual effects on cell cycle-controlled human dermal fibroblasts (HFFF2). These cells express receptors (H1, PAR2, TNFR1/2) for the major MC mediators, but only tryptase or a PAR2 agonist peptide stimulated proliferation and gene expression. TNF was antimitotic, and histamine, while elevating intracellular Ca2+ levels at high concentrations, did not affect proliferation. We conclude that MC products but also composition and numbers of respective receptors on fibroblasts are crucially responsible for fibroproliferative events.

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Correspondence to A. Mayerhofer.

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Received: 28 June 2005; received after revision 28 September 2005; accepted 6 October 2005

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Albrecht, M., Frungieri, M.B., Kunz, L. et al. Divergent effects of the major mast cell products histamine, tryptase and TNF-alpha on human fibroblast behaviour. Cell. Mol. Life Sci. 62, 2867–2876 (2005). https://doi.org/10.1007/s00018-005-5289-7

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  • DOI: https://doi.org/10.1007/s00018-005-5289-7

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