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The NF-κB signaling pathway in human genetic diseases

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Abstract.

The nuclear factor-κB (NF-κB) signaling pathway plays a key role in inflammation, immune response, cell growth control and protection against apoptosis. Recently, it has been associated with several distinct genetic diseases that exhibit a large spectrum of dysfunction, such as skin inflammation, perturbed skin appendage development and immunodeficiencies. In this review, a summary of the pathophysiological consequences of impaired NF-κB activation in humans is provided with respect to the functions of the molecules which are mutated.

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Correspondence to G. Courtois.

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Received 26 January 2005; received after revision 7 March 2005; accepted 31 March 2005

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Courtois, G. The NF-κB signaling pathway in human genetic diseases. CMLS, Cell. Mol. Life Sci. 62, 1682–1691 (2005). https://doi.org/10.1007/s00018-005-5031-5

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  • DOI: https://doi.org/10.1007/s00018-005-5031-5

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