Abstract.
The Rho family of small GTPases is involved in a diverse array of cellular processes, including regulation of the actin cytoskeleton, cell polarity, microtubule dynamics, membrane transport pathways and transcription factor activity. Recent findings have implicated the Rho proteins as key regulators of the skeletal myogenic program; however, much controversy presently exists as to the precise role of these proteins in this process. This review examines the present controversial findings pertaining to the Rho family’s regulation of skeletal myogenesis and extrapolates from both other differentiation systems and recently published data the possible mechanisms by which these proteins function in the myogenic cascade.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Corresponding author
Additional information
Received 20 January 2005; received after revision 17 February 2005; accepted 15 March 2005
Rights and permissions
About this article
Cite this article
Bryan, B.A., Li, D., Wu, X. et al. The Rho family of small GTPases: crucial regulators of skeletal myogenesis. CMLS, Cell. Mol. Life Sci. 62, 1547–1555 (2005). https://doi.org/10.1007/s00018-005-5029-z
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00018-005-5029-z