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Tissue-resident immune cells in the pathogenesis of multiple sclerosis

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Abstract

Background

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system (CNS) in which genetic and environmental factors contribute to disease progression. Both innate and adaptive immune cells, including T cells, B cells, activated macrophages and microglia, have been identified to be involved in the pathogenesis of MS, leading to the CNS inflammation, neurodegeneration and demyelination. In recent years, there has been considerable progress in understanding the contribution of tissue-resident immune cells in the pathogenesis of MS.

Methods

We performed a keyword-based search in PubMed database. We combined “multiple sclerosis” with keywords, such as tissue-resident memory T cells, microglia to search for relevant literatures in PubMed.

Results and conclusion

In this review, we comprehensively describe the characteristics of tissue-resident memory T cells and microglia, summarize their role in the pathogenesis of MS, and discuss their interaction with other immune cells in the CNS.

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Data availability

The data that support the findings of this study are available from the corresponding author, upon reasonable request.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81971542, 82171771, 82271854), the Young Talent Cultivation Program of Jiangsu University.

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Authors and Affiliations

  1. Institute of Medical Immunology, Affiliated Hospital of Jiangsu University, Zhenjiang, 212000, China

    Jie Tian & Ke Rui

  2. Department of Laboratory Medicine, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, China

    Jie Tian, Lingli Jiang, Zixiang Chen, Qingfang Yuan & Chang Liu

  3. Department of Obstetrics, Affiliated Hospital of Jiangsu University, Zhenjiang, China

    Longfeng He

  4. Department of Pediatrics, Affiliated Hospital of Jiangsu University, Zhenjiang, China

    Feng Jiang

  5. Department of Laboratory Medicine, Affiliated Hospital of Jiangsu University, Zhenjiang, China

    Ke Rui

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  1. Jie Tian
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  2. Lingli Jiang
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  4. Qingfang Yuan
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  5. Chang Liu
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  7. Feng Jiang
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  8. Ke Rui
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KR conceptualized the study. JT wrote the manuscript. All the authors contributed to manuscript editing and revision.

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Correspondence to Ke Rui.

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Tian, J., Jiang, L., Chen, Z. et al. Tissue-resident immune cells in the pathogenesis of multiple sclerosis. Inflamm. Res. 72, 363–372 (2023). https://doi.org/10.1007/s00011-022-01677-w

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  • DOI: https://doi.org/10.1007/s00011-022-01677-w

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