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Inflammation, a link between obesity and atrial fibrillation

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Abstract

Despite the long belief that the role of the adipose tissue was restricted to that of a passive store of triglycerides and a rich source of fatty acids, accumulating data demonstrates that the adipose tissue acts as an endocrine organ, capable of producing a large number of cytokines incriminated in generating a systemic inflammatory status. At its turn, this adiposity-related pro-inflammatory status appears to promote a large range of cardiovascular disorders, including atrial fibrillation (AF). Recent studies suggest that, in addition to systemic adiposity, the volume of the pericardial fat of the entire heart, and particularly of that overlying the atria, may represent an even more important risk factor for AF. This review focuses on the most relevant clinical and experimental data that bridge adiposity-induced inflammation and AF, and provides, through a multidisciplinary approach, a discussion that integrates both the current knowledge regarding the prolific activity of systemic and pericardial adipose tissue as sources of inflammatory mediators and the main effects of adiposity-induced inflammation on the most relevant electrophysiological, structural, and autonomic mechanisms responsible for AF.

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Acknowledgments

This work was supported by the University of Medicine and Pharmacy of Tîrgu Mureş Research Grant number 16/11.12.2013.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Physiology Department, University of Medicine and Pharmacy of Tîrgu Mureş, 38, Gheorghe Marinescu Street, 540139, Tîrgu Mureş, Romania

    Alina Scridon, Dan Dobreanu & Răzvan Constantin Şerban

  2. Emergency Institute for Cardiovascular Diseases and Transplantation Tîrgu Mureş, 540136, Tîrgu Mureş, Romania

    Dan Dobreanu & Răzvan Constantin Şerban

  3. Service de Rythmologie, Hospices Civils de Lyon, Hôpital Louis Pradel, 69500, Bron Cedex, France

    Philippe Chevalier

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  1. Alina Scridon
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  2. Dan Dobreanu
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Correspondence to Alina Scridon.

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Scridon, A., Dobreanu, D., Chevalier, P. et al. Inflammation, a link between obesity and atrial fibrillation. Inflamm. Res. 64, 383–393 (2015). https://doi.org/10.1007/s00011-015-0827-8

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  • DOI: https://doi.org/10.1007/s00011-015-0827-8

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