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Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population

  • Original Research Paper
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Abstract

Objective

The aim to this study was to investigate the association between the single-nucleotide polymorphisms (SNPs) of interleukin (IL)-23 receptor gene and systemic lupus erythematosus (SLE) in a Chinese population.

Methods

A case–control study was performed to investigate the associations of SNPs in IL-23R gene (rs10889677 and rs1884444) with susceptibility to SLE in 521 Chinese SLE patients and 527 normal controls. The chi-square test and unconditional Logistic regression were used to analysis by SPSS 10.1 software.

Results

No significant differences were detected for the distribution of allele and genotype frequencies of these two SNPs between patients and controls as well as SLE patients with nephritis (LN) and those without nephritis.

Conclusion

The findings suggest that the polymorphisms of IL-23R gene might not contribute to the susceptibility of SLE in the Chinese population.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (81172764, 30830089), the Specialized Research Fund for the Doctoral Program of Higher Education of China (20113420110005) and School Research Fund of Anhui Medical University (2010xkj012). We wish to thank the patients and normal controls for their cooperation.

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Gui-Mei Chen, Chen-Chen Feng, Juan Wang, Han Cen, Rui Li, Hui Peng, Mo Zhou, Rui-Xue Leng, Yin-Guang Fan, Hai-Feng Pan & Dong-Qing Ye

  2. Anhui Provincial Laboratory of Population Health and Major Disease Screening and Diagnosis, 81 Meishan Road, Hefei, 230032, Anhui, People’s Republic of China

    Gui-Mei Chen, Chen-Chen Feng, Juan Wang, Han Cen, Rui Li, Hui Peng, Mo Zhou, Rui-Xue Leng, Yin-Guang Fan, Hai-Feng Pan & Dong-Qing Ye

  3. Department of Hematology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, People’s Republic of China

    Qian-Ling Ye

  4. Department of Rheumatology and Immunology, Anhui Provincial Hospital, 17 Lujiang Road, Hefei, Anhui, 230001, People’s Republic of China

    Jin-Hui Tao

Authors
  1. Gui-Mei Chen
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  2. Chen-Chen Feng
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  13. Dong-Qing Ye
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Corresponding author

Correspondence to Dong-Qing Ye.

Additional information

Responsible Editor: Graham R. Wallace.

G.-M. Chen and C.-C. Feng contributed equally to this work and should be considered co-first authors.

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Chen, GM., Feng, CC., Ye, QL. et al. Lack of association between IL-23R gene polymorphisms and systemic lupus erythematosus in a Chinese population. Inflamm. Res. 62, 791–795 (2013). https://doi.org/10.1007/s00011-013-0636-x

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  • DOI: https://doi.org/10.1007/s00011-013-0636-x

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