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Th17 cell cytokine secretion profile in host defense and autoimmunity

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Abstract

Objective and design

The goal of this review is to examine the effector functions of Th17 cells in host defense and autoimmunity.

Material

Published literature on Th17 cells was reviewed with a focus on the secreted products that mediate effector activities of these cells.

Results

Th17 cells secrete an array of cytokines that contribute to host defense and that bridge the innate and adaptive arms of the immune response. When this subset of T cells is dysregulated, autoimmune phenomena develop that contribute to the manifestations of many autoimmune diseases.

Conclusions

Th17 cells are positioned at a crossroads between innate and adaptive immunity and provide mediators that are essential for host defense. Current interest in harnessing this system for treatment of autoimmune disease will be challenged by the need to avoid abrogating these many protective functions.

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Acknowledgments

We are grateful to Dr. Susan Kaech and Dr. Joseph Craft of Yale University for their guidance and encouragement. K.E.G. was supported by a medical student award from the American College of Rheumatology, Research and Education Foundation.

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  1. Department of Medicine, M.S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA, 17033, USA

    Kristen E. Graeber

  2. Department of Medicine, M.S. Hershey Medical Center, The Pennsylvania State University, 500 University Drive, Hershey, PA, 17033, USA

    Nancy J. Olsen

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Correspondence to Nancy J. Olsen.

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Graeber, K.E., Olsen, N.J. Th17 cell cytokine secretion profile in host defense and autoimmunity. Inflamm. Res. 61, 87–96 (2012). https://doi.org/10.1007/s00011-011-0419-1

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