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Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology

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Reviews of Physiology, Biochemistry and Experimental Pharmacology

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References

  • Abrahams, V. C., Langworthy, E. P., Theobald, G. W.: Potentials evoked in the hypothalamus and cerebral cortex by electrical stimulation of the uterus. Nature (Lond.) 203, 654–656 (1964).

    CAS  Google Scholar 

  • Adair, F. L., Haugen, J. A.: A study of suspended human uterine muscle strips in vitro. Amer. J. Obstet. Gynec. 37, 753–761 (1939).

    CAS  Google Scholar 

  • Adrian, E. D., Bronk, D. W., Phillips, G.: Discharges in mammalian sympathetic nerves. J. Physiol. (Lond.) 74, 115–133 (1932).

    CAS  Google Scholar 

  • Ahlquist, R. P.: A study of the adrenotropic receptors. Amer. J. Physiol. 153, 586–600 (1948).

    PubMed  CAS  Google Scholar 

  • — The adrenergic receptor. J. pharm. Sci. 55, 359–370 (1966).

    PubMed  CAS  Google Scholar 

  • Anderson, L. L., Bowerman, A. M., Melampy, R. M.: Neuro-utero-ovarian relationships. In: Advances in Neuroendocrinology. Urbana: Univ. Illinois Press 1963.

    Google Scholar 

  • Anderson, N. C.: Voltage-clamp studies of uterine smooth muscle. J. gen. Physiol. 54, 145–166 (1969).

    PubMed  Google Scholar 

  • Balassa, G.: Uterine potentials. J. Pharmacol. exp. Ther. 70, 189–200 (1940).

    CAS  Google Scholar 

  • Barden, T. P., Stander, R. W.: Effects of adrenergic blocking agents and catecholamines in human pregnancy. Amer. J. Obstet. Gynec. 102, 226–235 (1968).

    PubMed  CAS  Google Scholar 

  • Barnea, A., Shelesnyak, M. C.: The catecholamine content of the uterus, ovary and hypophysis during early pregnancy. J. Endocr. 31, 271–278 (1965).

    PubMed  CAS  Google Scholar 

  • Barraclough, C. A., Cross, B. A.: Unit activity in the hypothalamus of the cyclic female rat: effect of genital stimuli and progesterone. J. Endocr. 26, 339–359 (1963).

    PubMed  CAS  Google Scholar 

  • Bell, C.: Dual vasoconstrictor and vasodilator innervation of the uterine arterial supply in the guinea pig. Circulat. Res. 23, 279–289 (1968).

    PubMed  CAS  Google Scholar 

  • Bergman, R. A.: Uterine smooth muscle fibers in castrate and estrogen-treated rats. J. Cell Biol. 36, 639–648 (1968).

    PubMed  CAS  Google Scholar 

  • Bertler, A., Carlsson, A., Rosengren, E.: A method for the fluorimetric determination of adrenaline and noradrenaline in tissues. Acta physiol. scand. 44, 273–292 (1958).

    PubMed  CAS  Google Scholar 

  • Bissett, G. W., Haldar, J., Lewin, J. E.: Actions of oxytocin and other biologically active peptides on the rat uterus. Mem. Soc. Endocr. 14, 185–204 (1966).

    Google Scholar 

  • Bower, E. A.: The characteristics of spontaneous and evoked action potentials recorded from the rabbit’s uterine nerves. J. Physiol. (Lond.) 183, 730–747 (1966a).

    CAS  Google Scholar 

  • Bower, E. A.: The activity of post-ganglionic sympathetic nerves to the uterus of the rabbit. J. Physiol. (Lond.) 183, 748–767 (1966b).

    CAS  Google Scholar 

  • Bowman, W. C., Nott, M. W.: Actions of sympathomimetic amines and their antagonists on skeletal muscle. Pharmacol. Rev. 21, 27–72 (1969).

    PubMed  CAS  Google Scholar 

  • Bronk, D. W., Tower, S. S., Soldant, D. Y., Larrabee, M. G.: The transmission of trains of impulses through a sympathetic ganglion and in its postganglionic nerves. Amer. J. Physiol. 122, 1–15 (1938).

    Google Scholar 

  • Brooks, J. R., Schaeppi, U., Pincus, G.: Evidence for the presence of alpha adrenergic excitatory receptors in the rat uterus. Life Sci. 4, 1817–1821 (1965).

    PubMed  CAS  Google Scholar 

  • Brundin, J.: An occlusive mechanism in the fallopian tube of the rabbit. Acta physiol. scand. 61, 219–227 (1964).

    PubMed  CAS  Google Scholar 

  • — Distribution and function of adrenergic nerves in the rabbit fallopian tube. Acta physiol. scand. 66, 5–57 (1965).

    Google Scholar 

  • Bueding, E., Bülbring, E.: The inhibitory action of adrenaline. In: Pharmacology of Smooth Muscle. Proc. 2nd. Int. Pharmacol. Meeting, vol. 6, p. 37–56. Oxford: Pergamon 1964.

    Google Scholar 

  • — — Gerken, G., Hawkins, J. T., Kuriyama, H.: The effect of adrenaline on the adenosine tri-phosphate and createnine phosphate content of intestinal smooth muscle. J. Physiol. (Lond.) 193, 197–212 (1967).

    Google Scholar 

  • Bülbring, E., Casteels, R., Kuriyama, H.: Membrane potential and ion content in cat and guinea-pig myometrium and the response to adrenaline and noradrenaline. Brit. J. Pharmacol. 34, 388–407 (1968).

    Google Scholar 

  • Burdick, H. O., Pincus, G.: The effect of estrin injections upon the development of ova in mice and rabbits. Amer. J. Physiol. 111, 201–208 (1935).

    Google Scholar 

  • Burnstock, G., Campbell, G., Bennett, M., Holman, M. E.: Inhibition of the smooth muscle of the taenia coli. Nature (Lond.) 200, 581–582 (1963).

    CAS  Google Scholar 

  • — Holman, M. E.: The transmission of excitation from autonomic nerve to smooth muscle. J. Physiol. (Lond.) 155, 115–133 (1961).

    CAS  Google Scholar 

  • — —Junction potentials at adrenergic synapses. Pharmacol. Rev. 18, 481–493 (1966a).

    PubMed  CAS  Google Scholar 

  • — —Effect of drugs on smooth muscle. Ann. Rev. Pharmacol. 6, 129–156 (1966b).

    PubMed  CAS  Google Scholar 

  • — — Prosser, C. L.: Electrophysiology of smooth muscle. Physiol. Rev. 43, 482–527 (1963).

    PubMed  CAS  Google Scholar 

  • — Robinson, P. M.: Localization of catecholamines and acetylcholinesterase in autonomic nerves. Circulat. Res., Suppl. III, 21, 43–55 (1967).

    CAS  Google Scholar 

  • Caesar, R., Edwards, G. A., Ruska, H.: Architecture and nerve supply of mammalian smooth muscle tissue. J. biophys. biochem. Cytol. 3, 867–878 (1957).

    PubMed  CAS  Google Scholar 

  • Caldeyro-Barcia, R., Alvarez, H.: Effect of presacral nerve stimulation on the contractility of the nonpregnant human uterus. J. appl. Physiol. 6, 556–558 (1954).

    PubMed  CAS  Google Scholar 

  • Cannon, W. B., Bacq, Z. M.: Studies on the conditions of activity in endocrine organs. XXVI. A hormone produced by sympathetic action on muscle. Amer. J. Physiol. 96, 392–412 (1931).

    CAS  Google Scholar 

  • Carlsson, A., Falck, B., Hillarp, N. A.: Cellular localization of monoamines. Acta physiol. scand., Suppl. 196, 56, 1–28 (1962).

    CAS  Google Scholar 

  • — Rosengren, E., Bertler, Ã…., Nilsson, J.: Effect of reserpine on the metabolism of catecholamines. In: Psychotropic Drugs. Amsterdam: Elsevier Publ. Co. 1957.

    Google Scholar 

  • Celander, O.: The range of control exercised by the sympathico-adrenal system. Acta. physiol. scand. 32, Suppl. 116, 1–132 (1954).

    CAS  Google Scholar 

  • Cha, K. S., Lee, W. C., Rudzik, A., Miller, J. W.: A comparison of the catecholamine concentrations of uteri from several species and the alterations which occur during pregnancy. J. Pharmacol. exp. Ther. 148, 9–13 (1965).

    PubMed  CAS  Google Scholar 

  • Cibils, L. A., Pose, S. V., Zuspan, F. P.: The effect of 1-norepinephrine infusion on uterine contractility and cardiovascular system. Amer. J. Obstet. Gynec. 84, 307–317 (1962).

    PubMed  CAS  Google Scholar 

  • Clegg, P. C.: The effect of adrenergic blocking agents on the guinea-pig uterus in vitro and a study of the histology of the intrinsic myometrial nerves. J. Physiol. (Lond.) 169, 73–90 (1962).

    Google Scholar 

  • Coppola, J. A., Leonardi, R. G., Lipmann, W.: Ovulatory failure in rats after treatment with brain norepinephrine depletor. Endocrinology 78, 225–228 (1966).

    PubMed  CAS  Google Scholar 

  • Cross, B. A.: The motility and reactivity of the oestrogenized rabbit uterus in vivo; with comparative observations on milk ejection. J. Endocr. 16, 237–260 (1958).

    PubMed  CAS  Google Scholar 

  • Crout, J. R., Creveling, C. R., Udenfriend, S.: Norepinephrine metabolism in rat brain and heart. J. Pharmacol. exp. Ther. 132, 269–273 (1961).

    PubMed  CAS  Google Scholar 

  • Csapo, A., Goodall, M.: Excitability, length tension relation and kinetics of uterine muscle contraction in relation to hormonal status. J. Physiol. (Lond.) 126, 384–395 (1954).

    CAS  Google Scholar 

  • —, Kuriyama, H. A.: Effects of ions and drugs on cell membrane activity and tension in the postpartum rat myometrium. J. Physiol. (Lond.) 165, 575–592 (1963).

    CAS  Google Scholar 

  • Cushny, A. R.: On the movements of the uterus. J. Physiol. (Lond.) 35, 1–19 (1906).

    CAS  Google Scholar 

  • Dahlström, A., Fuxe, K.: Monoamines and the pituitary gland. Acta endocr. (Kbh.) 51, 301–314 (1966).

    Google Scholar 

  • Dale, H. H.: On some physiological actions of ergot. J. Physiol. (Lond.) 34, 163–206 (1906).

    Google Scholar 

  • — Nomenclature of fibres in the autonomic system and their effects. J. Physiol. (Lond.) 80, 10–11 (1933).

    Google Scholar 

  • — Nomenclature of fibres in the autonomic system and their effects. In: Adventures in physiology, p. 528–529. London: Pergamon Press 1953.

    Google Scholar 

  • — The beginnings and the prospects of neurohumoral transmission. Pharmacol. Rev. 6, 7–13 (1954).

    PubMed  CAS  Google Scholar 

  • — Laidlaw, P. P.: The significance of the suprarenal capsules in the action of certain alkaloids. J. Physiol. (Lond.) 45, 1–23 (1912).

    CAS  Google Scholar 

  • Daniel, E. E., Robinson, K.: The secretion of sodium and uptake of potassium by isolated uterine segments made sodium-rich. J. Physiol. (Lond.) 154, 421–445 (1960).

    CAS  Google Scholar 

  • David, A., Czernobilsky, B.: A comparative histologic study of the uterotubal junction in the rabbit, rhesus monkey, and the human female. Amer. J. Obstet. Gynec. 101, 417–421 (1968).

    PubMed  CAS  Google Scholar 

  • Davidson, W. J., Ikoku, C.: The adrenergic receptors in the guinea-pig uterus. Canad. J. Physiol. Pharmac. 44, 491–493 (1966).

    CAS  Google Scholar 

  • Davies, P. W.: The action potential. In: Medical physiology. St. Louis: C. V. Mosby Co. 1968.

    Google Scholar 

  • Davis, A. A.: The innervation of the uterus. J. Obstet. Gynaec. 40, 481–497 (1933).

    Google Scholar 

  • Deanesly, R.: The effects of reserpine on ovulation and on the corpus luteum of the guinea-pig. J. Reprod. Fertil. 11, 429–438 (1966).

    PubMed  CAS  Google Scholar 

  • Diamond, J., Brody, T. M.: Effect of catecholamines on smooth muscle motility and phosphorylase activity. J. Pharmacol. exp. Ther. 152, 202–211 (1966a).

    PubMed  CAS  Google Scholar 

  • — — Relationship between smooth muscle contraction and phosphorylase activation. J. Pharmacol. exp. Ther. 152, 212–220 (1966b).

    PubMed  CAS  Google Scholar 

  • — — Hormonal alteration of the response of the rat uterus to catecholamines. Life Sci. 5, 2187–2193 (1966c).

    CAS  Google Scholar 

  • — Marshall, J. M.: Smooth muscle relaxants; dissociation between resting membrane potential and resting tension in the myometrium. J. Pharmacol. exp. Ther. 168, 13–20 (1969a).

    PubMed  CAS  Google Scholar 

  • — — A comparison of the effects of various smooth muscle relaxants on the electrical and mechanical activity of the rat uterus. J. Pharmacol. exp. Ther. 168, 21–30 (1969b).

    PubMed  CAS  Google Scholar 

  • Edman, K. A. P., Schild, H. O.: Calcium and the stimulant and inhibitory effects of adrenaline in depolarized smooth muscle. J. Physiol. (Lond.) 169, 404–411 (1963).

    CAS  Google Scholar 

  • El-Badawi, A., Schenk, E. A.: The peripheral adrenergic innervation apparatus. I. Intraganglionic and extraganglionic adrenergic ganglion cells. Z. Zellforsch., Abt. Histochem. 87, 218–225 (1968).

    CAS  Google Scholar 

  • Eränko, O.: Histochemistry of nervous tissues: Catecholamines and cholinesterases. Ann. Rev. Pharmacol. 7, 203–222 (1967).

    PubMed  Google Scholar 

  • Eskes, T., Stolte, L., Seelen, J., Mold, H. D., Vogelsang, C.: Epinephrine derivates and the activity of the human uterus. II. The influence of pronethalol and propranolol on the uterine and systemic activity of p-hydroxphenylisopropylarterenol (Cc-25). Amer. J. Obstet. Gynec. 92, 871–881 (1965).

    PubMed  CAS  Google Scholar 

  • Euler, U. S. von, Lishajko, F.: A specific kind of noradrenaline granules in the vesicular gland and the vas deferens of the bull. Life Sci. 5, 687–691 (1966).

    CAS  Google Scholar 

  • Everett, J. W.: Central neural control of reproductive functions of the adenohypophysis. Physiol. Rev. 44, 374–431 (1964).

    Google Scholar 

  • Falck, B.: Observations on the possibilities of the cellular localization of monoamines by a fluorescence method. Acta physiol. scand. 56, 197, 1–25 (1962).

    Google Scholar 

  • — Hillarp, N. A., Thiene, G., Torp, A.: Fluorescence of catecholamines and related compounds condensed with formaldehyde. J. Histochem. Cytochem. 10, 348–354 (1962).

    CAS  Google Scholar 

  • Feldberg, W.: Henry Hallett Dale, 1875–1968. Brit. J. Pharmacol. 35, 1–9 (1969).

    CAS  Google Scholar 

  • Ferguson, J. K. W.: A study of the motility of the intact uterus at term. Surg. Gynec. Obstet. 73, 359–366 (1941).

    Google Scholar 

  • Ferry, C. B.: The innervation of the vas deferens of the guinea-pig. J. Physiol. (Lond.) 192, 463–478 (1967).

    CAS  Google Scholar 

  • Folkow, B.: Impulse frequency in sympathetic vasomotor fibres correlated to the release and elimination of the transmitter. Acta physiol. scand. 25, 49–76 (1952).

    PubMed  CAS  Google Scholar 

  • Frankenhäuser, F.: Die Nerven der Gebärmutter und ihre Endigungen in den glatten Muskelfasern. Ein Beitrag zur Anatomie und Gynäkologie. Jena: Mauke 1867.

    Google Scholar 

  • Freund, M., Wiederman, J., Saphier, A.: A method for the simultaneous recording, in vitro, of the motility of the vagina, of the body of the uterus, and of both uterine horns in the guinea pig. Fertil. and Steril. 14, 416–430 (1963).

    CAS  Google Scholar 

  • Fuxe, E.: Cellular localization of monoamines in the median eminence and the infundibular stem of some mammals. Z. Zellforsch., Abt. Histochem. 61, 710–724 (1964).

    CAS  Google Scholar 

  • Gaddum, J. H.: The action of adrenalin and ergotamine on the uterus of the rabbit. J. Physiol. (Lond.) 61, 141–150 (1926).

    CAS  Google Scholar 

  • Gaffney, E., Burket, R. L., Woronkow, S.: Catecholamine content of the pregnant and nonpregnant human uterus. Obstet. and Gynec. 25, 340–342 (1965).

    CAS  Google Scholar 

  • Gansler, H.: Phasenkontrast-und elektronenmikroskopische Untersuchungen zur Innervation der glatten Muskulatur. Acta neuroveg. (Wien) 22, 192–211 (1960).

    Google Scholar 

  • Garrett, W. J.: The effects of adrenaline and noradrenaline on the intact human uterus in late pregnancy and labour. J. Obstet. Gynaec. Brit. Emp. 61, 586–592 (1954).

    PubMed  CAS  Google Scholar 

  • — The effects of adrenaline and noradrenaline on the intact nonpregnant human uterus. J. Obstet. Gynaec. Brit. Emp. 62, 876–881 (1955a).

    PubMed  CAS  Google Scholar 

  • — The effects of adrenaline, noradrenaline and dihydroergotamine on excised human myometrium. Brit. J. Pharmacol. 10, 39–42 (1955b).

    PubMed  CAS  Google Scholar 

  • Gaunt, R., Chart, J. J., Renzi, A. A.: Interactions of drugs with endocrines. Ann. Rev. Pharmacol. 3, 109–127 (1963).

    Google Scholar 

  • Gillespie, J. S.: The mode of action of catecholamines on smooth muscle. Mem. Soc. Endocr. 14, 155–167 (1966).

    Google Scholar 

  • Graham, J. P. D., Gurd, M. R.: Effects of adrenaline on the isolated uterus of the cat. J. Physiol. (Lond.) 152, 243–249 (1960).

    CAS  Google Scholar 

  • Greeff, K., Holtz, P.: Ãœber die Uteruswirkung des Adrenalins und Arterenols. Ein Beitrag zum Problem der Uterusinnervation. Arch. int. Pharmacodyn. 88, 228–252 (1951).

    PubMed  CAS  Google Scholar 

  • Green, R. D., Miller, J. W.: Catecholamine concentrations. Changes in plasma of rats during estrous cycle and pregnancy. Science 151, 825–826 (1966a).

    PubMed  CAS  Google Scholar 

  • — —The effect of various substances on the efflux of labeled catecholamines from the uterus of the rat. J. Pharmacol. exp. Ther. 152, 439–444 (1966b).

    PubMed  CAS  Google Scholar 

  • Greenwald, G. S.: In vivo recording of intraluminal pressure change in the rabbit oviduct. Fertil. and Steril. 14, 665–672 (1963).

    Google Scholar 

  • Greiss, F. C.: The uterine vascular bed: effect of adrenergic stimulation. Obstet. and Gynec. 21, 295–301 (1963).

    CAS  Google Scholar 

  • — Gobble, F. L.: Effect of sympathetic nerve stimulation on the uterine vascular bed. Amer. J. Obstet. Gynec. 97, 962–967 (1967).

    PubMed  Google Scholar 

  • — Gobble, Jr., F. L., Anderson, S. G., McGuirt, W. F.: Effect of parasympathetic nerve stimulation on the uterine vascular bed. Amer. J. Obstet. Gynec. 99, 1067–1072 (1967).

    PubMed  Google Scholar 

  • Gross, F., Tripod, J., Meier, R.: Regitin (Präparat C 7337) ein neues Imidazolinderivat mit spezifischer sympathikolytischer Wirkung. Schweiz. med. Wschr. 81, 352–357 (1951).

    PubMed  CAS  Google Scholar 

  • Gruber, C. M.: The autonomic innervation of the genito-urinary system. Physiol. Rev. 13, 497–609 (1933).

    Google Scholar 

  • Gunn, J. A., Franklin, K. J.: The sympathetic innervation of the vagina. Proc. roy. Soc. B 94, 197–203 (1922).

    Google Scholar 

  • Gustavson, R. G., Dyke, H. B. van: Further observations on the pregnancy response if the uterus of the cat. J. Pharmacol. exp. Ther. 41, 139–146 (1931).

    CAS  Google Scholar 

  • Gutman, Y., Weil-Malherbe, H.: Subcellular distribution of norepinephrine in uteri of some species. Nature (Lond.) 214, 108–109 (1967).

    CAS  Google Scholar 

  • Harman, J. W., O’Hegarty, M. T., Byrnes, C. R.: The ultrastructure of human smooth muscle. Exp. molec. Path. 1, 204–227 (1962).

    PubMed  CAS  Google Scholar 

  • Hasama, B.: Elektrophysiologische Untersuchungen über die Uterusbewegungen. Pflügers Arch. ges. Physiol. 229, 100–112 (1931).

    Google Scholar 

  • Hawkins, D. F.: Some pharmacological reactions of isolated rings of human fallopian tube. Arch. int. Pharmacodyn. 152, 474–481 (1964).

    PubMed  CAS  Google Scholar 

  • Hermansen, K.: The effect of adrenaline, noradrenaline and isoprenaline on the guinea-pig uterus. Brit. J. Pharmacol. 16, 116–128 (1961).

    PubMed  CAS  Google Scholar 

  • Holman, M. E.: Some electrophysiological aspects of transmission from noradrenergic nerves to smooth muscle. Circulat. Res., Suppl. III, 21, 71–81 (1967).

    CAS  Google Scholar 

  • Hopkins, T. F., Pincus, G.: Effects of reserpine on gonadotropin-induced ovulation in immature rats. Endocrinology 73, 775–780 (1966).

    Google Scholar 

  • Jacobowitz, D., Wallach, E. E.: Histochemical and chemical studies of the autonomic innervation of the ovary. Endocrinology 81, 1132–1139 (1967).

    PubMed  CAS  Google Scholar 

  • Jacobson, H. N., Nieves, O.: Intrinsic nerve fibers of the primate endometrium. Exp. Neurol. 4, 180–187 (1961).

    PubMed  CAS  Google Scholar 

  • Jaeger, J.: Electronenoptische Untersuchungen an der glatten Muskulatur des menschlichen graviden Uterus. Gynaecologia (Basel) 154, 193–205 (1962).

    CAS  Google Scholar 

  • Jensen, K. B., Vennerod, A. M.: Reversal of the inhibitory action of adrenaline and histamine on the rat uterus. Acta pharmacol. (Kbh). 18, 298–306 (1961).

    CAS  Google Scholar 

  • Kahane, Z., Vestergaard, P.: An improved method for measurement of free epinephrine and norepinephrine with a phosphate-metaphosphate buffer in the trihydroxyinodole procedure. J. Lab. clin. Med. 65, 848–858 (1965).

    PubMed  CAS  Google Scholar 

  • Kaiser, I. H., Harris, J. S.: The effect of adrenaline on the pregnant human uterus. Amer. J. Obstet. Gynec. 59, 775–784 (1950).

    Google Scholar 

  • Kao, C. Y.: Ionic basis of electrical activity in uterine smooth muscle. In: Cellular biology of the uterus. New York: Appleton-Century Crofts 1967.

    Google Scholar 

  • Klingman, G.: Catecholamine levels and dopa-decarboxylase activity in peripheral organs and adrenergic tissues in the rat after immunosympathectomy. J. Pharmacol. exp. Ther. 148, 14–21 (1965).

    PubMed  CAS  Google Scholar 

  • Kok, F.: Pharmacological influence on the muscles of the tube. A contribution to the question of the transport of the ovum. Zbl. Gynäk. 51, 2650–2662 (1927).

    Google Scholar 

  • Krantz, K. E.: Innervation of the human uterus. Ann. N.Y. Acad. Sci. 75, 770–784 (1959).

    PubMed  CAS  Google Scholar 

  • Kumar, O., Wagatsuma, T., Barnes, A. C.: In vitro hyperpolarizing effect of adrenaline on human myometrial cell. Amer. J. Obstet. Gynec. 91, 575–577 (1965).

    PubMed  CAS  Google Scholar 

  • Kushiya, I.: An electron microscope study of muscular coats in the ampulla of the rabbit oviduct, with special references to the neuromuscular relationship. J. Electron Micr. 17, 127–138 (1968).

    CAS  Google Scholar 

  • Labate, J. S.: Influence of cocaine on the uterine reaction induced by adrenaline and hypogastric nerve stimulation. J. Pharmacol. exp. Ther. 72, 370–382 (1941).

    CAS  Google Scholar 

  • Laguens, R., Lagrutta, J.: Fine structure of human uterine muscle in pregnancy. Amer. J. Obstet. Gynec. 89, 1040–1048 (1964).

    PubMed  CAS  Google Scholar 

  • Langley, J. N.: On the stimulation and paralysis of nerve cells and of nerve-endings. Part 1. J. Physiol. (Lond.) 27, 224–236 (1901a).

    CAS  Google Scholar 

  • — Observations on the physiological action of extracts of the supra-renal bodies. J. Physiol. (Lond.) 27, 237–256 (1901b).

    CAS  Google Scholar 

  • — Anderson, H. K.: The constituents of the hypogastric nerves. J. Physiol. (Lond.) 17, 177–191 (1894).

    CAS  Google Scholar 

  • — —The innervation of the pelvic and adjoining viscera. Part IV. The internal generative organs. J. Physiol. (Lond.) 19, 122–130 (1895a).

    Google Scholar 

  • — —The innervation of the pelvic and adjoining viscera. Part V. Position of the nerve cells on the course of the efferent nerve fibres. J. Physiol. (Lond.) 19, 131–139 (1895b).

    Google Scholar 

  • — —The innervation of the pelvic and adjoining viscera. Part VII. Anatomical observations. J. Physiol. (Lond.) 20, 372–406 (1896).

    CAS  Google Scholar 

  • Lehrer, D. N.: The effect of spasmolytic agents on the isolated human myometrium. J. Pharm. Pharmacol. 17, 584–592 (1965).

    PubMed  CAS  Google Scholar 

  • Lempinen, M.: Extra-adrenal chromaffin tissue of the rat and the effect of cortical hormones on it. Acta physiol. scand. 62, Suppl. 231 (1964).

    Google Scholar 

  • Levy, B., Tozzi, S.: The adrenergic receptive mechanism of the rat uterus. J. Pharmacol. exp. Ther. 142, 178–184 (1963).

    PubMed  CAS  Google Scholar 

  • Loewi, O.: Ãœber humorale Ãœbertragbarkeit der Herznervenwirkung. I. Mitt. Pflügers Arch. ges. Physiol. 189, 239–242 (1921).

    Google Scholar 

  • Malmfors, T.: Studies on adrenergic nerves. Acta. physiol. scand. 64, Suppl. 248, 7–95 (1965).

    Google Scholar 

  • Mann, M., West, G. B.: The nature of uterine and intestinal sympathin. Brit. J. Pharmacol. 6, 79–82 (1951).

    PubMed  CAS  Google Scholar 

  • Marshall, J. M.: Effects of estrogen and progesterone on single uterine muscle fibers in the rat. Amer. J. Physiol. 197, 936–941 (1959).

    Google Scholar 

  • — Comparative aspects of the pharmacology of smooth muscle. Fed. Proc. 26, 1104–1110 (1967).

    PubMed  CAS  Google Scholar 

  • — Relation between the ionic environment and the action of drugs on the myometrium. Fed. Proc. 27, 115–119 (1968).

    PubMed  CAS  Google Scholar 

  • Meyerson, B. J., Sawyer, C. H.: Monoamines and ovulation in the rat. Endocrinology 83, 170–176 (1968).

    PubMed  CAS  Google Scholar 

  • Miller, E. G., Cockerill, J. R., Kurzrok, R.: Reactions of human uterine muscle in vitro to pituitrin, adrenaline and acetylcholine and their relations to the menstrual cycle. Amer. J. Obstet. Gynec. 33, 154–156 (1937).

    CAS  Google Scholar 

  • Miller, J. W.: Adrenergic receptors in the myometrium. Ann. N.Y. Acad. Sci. 139, 788–798 (1967).

    PubMed  CAS  Google Scholar 

  • Miller, M. D., Marshall, J. M.: Uterine response to nerve stimulation; relation to hormonal status and catecholamines. Amer. J. Physiol. 209, 859–865 (1965).

    PubMed  CAS  Google Scholar 

  • Mitchell, G. A. G.: The innervation of the ovary, uterine tube, testis and epididymis. J. Anat. (Lond.) 72, 508–517 (1938).

    CAS  Google Scholar 

  • Morison, R. S.: The effects of adrenaline and of nerve stimulation on the mechanical and electric responses of uterine muscle. Amer. J. Physiol. 128, 372–381 (1940).

    CAS  Google Scholar 

  • Murakami, S., Fujita, I.: About the action of several pharmaceuticals upon the uterus and the tubes. Folia pharmacol. jap. 23, 31–45 (1937).

    Google Scholar 

  • Nakanishi, H., Wansbrough, H., Wood, C.: Postganglionic sympathetic nerve innervating human fallopian tube. Amer. J. Physiol. 213, 613–619 (1967).

    PubMed  CAS  Google Scholar 

  • — Wood, C.: Effects of adrenergic blocking agents on human fallopian tube motility in vitro. J. Reprod. Fertil. 16, 21–28 (1968).

    PubMed  CAS  Google Scholar 

  • Nickerson, M., Goodman, L. S.: Pharmacological properties of a new adrenergic blocking agent: N,N-Dibenzyl-β-chlorethylamine (Dibenamine). J. Pharmacol. exp. Ther. 89, 167–185 (1947).

    PubMed  CAS  Google Scholar 

  • Nilsson, R.: Rate of depletion of noradrenaline in some peripheral tissue induced by a reserpine injection. Experientia (Basel) 20, 679 (1964).

    CAS  Google Scholar 

  • Norberg, J. G., Rosengren, E., Sjöberg, N. O.: On the occurrence of 5-hydroxy-tryptamine containing cells in the vaginal and vestibular epithelium of the rabbit. Z. Zellforsch., Abt. Histochem. 63, 302–308 (1964).

    Google Scholar 

  • Norberg, K. A., Fredricsson, B.: Cellular distribution of monoamines in the uterine and tubal walls of the rat. Acta physiol. scand. 68, Suppl. 277, 149 (1966).

    Google Scholar 

  • — Hamberger, B.: The sympathetic adrenergic neuron. Some characteristics revealed by histochemical studies on the intraneuronal distribution of the transmitter. Acta physiol. scand. 63, Suppl. 238, 5–42 (1964).

    Google Scholar 

  • — Ritzen, M., Ungerstedt, U.: Histochemical studies on a special catecholamine-containing cell type in sympathetic ganglia. Acta. physiol. scand. 67, 260–270 (1966).

    PubMed  CAS  Google Scholar 

  • Orlov, R. S.: The intracellular recording of smooth muscle potentials during stimulation of excitatory and inhibitory nerves. J. Physiol. USSR 47, 500–503 (1961).

    PubMed  CAS  Google Scholar 

  • Oskarsson, V.: Influence of ovarian hormones and denervation on the catecholamines of the rat uterus. Acta. endocr. 34, 38–44 (1960).

    PubMed  CAS  Google Scholar 

  • Owman, C., Rosengren, E., Sjöberg, N. O.: Origin of the adrenergic innervation to the female genital tract of the rabbit. Life Sci. 5, 1389–1396 (1966).

    PubMed  CAS  Google Scholar 

  • — — —Adrenergic innervation of the human female reproductive organs: A histochemical and chemical investigation. J. Obstet. Gynaec. 30, 763–773 (1967).

    CAS  Google Scholar 

  • —, Sjöberg, N. O.: Adrenergic nerves in the female genital tract of the rabbit. With remarks on cholinesterase-containing structures. Z. Zellforsch., Abt. Histochem. 74, 182–197 (1966).

    CAS  Google Scholar 

  • — Sjöstrand, N. O.: Short adrenergic neurons and catecholamine-containing cells in vas deferens and accessory male genital glands of different mammals. Z. Zellforsch., Abt. Histochem. 66, 300–320 (1965).

    CAS  Google Scholar 

  • Pallie, W., Corner, G. W., Weddell, G.: Nerve terminations in the myometrium of the rabbit. Anat. Rec. 118, 789–812 (1954).

    PubMed  CAS  Google Scholar 

  • Paton, D. M.: The contractile response of the isolated rat uterus to noradrenaline and 5-hydroxytryptamine. Europ. J. Pharmacol. 3, 310–315 (1968).

    CAS  Google Scholar 

  • Pauerstein, C. J., Woodruff, J. D., Zachary, A. S.: Factors influencing physiologic activities in the fallopian tube, the anatomy, physiology and pharmacology of tubal transport. Obstet. gynec. Surv. 23, 215–243 (1968).

    CAS  Google Scholar 

  • Pennefather, J. N., Isaac, P. F.: The response of the isolated uterus of the guinea-pig to stimulation of the ovarian nerves during the oestrous cycle. Aust. J. exp. Biol. med. Sci. 45, 229–244 (1967).

    CAS  Google Scholar 

  • Pose, S. V., Cibils, L. A., Zuspan, F. P.: Effect of 1-epinephrine infusion on uterine contractility and cardiovascular system. Amer. J. Obstet. Gynec. 84, 297–306 (1962).

    PubMed  CAS  Google Scholar 

  • Reynolds, S. M. R.: Physiology of the uterus, 2nd ed. New York: Hafner Publ. Co. 1965.

    Google Scholar 

  • Richardson, K. C.: The fine structure of autonomic nerve endings in the smooth muscle of the rat vas deferens. J. Anat. (Lond.) 96, 427–442 (1962).

    CAS  Google Scholar 

  • Rosengren, E., Sjöberg, N. O.: The adrenergic nerve supply to the female reproductive tract of the cat. Amer. J. Anat. 121, 271–284 (1967).

    PubMed  CAS  Google Scholar 

  • — —Changes in the amount of adrenergic transmitter in the female genital tract of the rabbit during pregnancy. Acta. physiol. scand. 72, 412–424 (1968).

    PubMed  CAS  Google Scholar 

  • Rudolph, L., Ivy, A. C.: The physiology of the uterus in labor. Amer. J. Obstet. Gynec. 19, 317–335 (1930).

    Google Scholar 

  • Rudzik, A. D., Miller, J. W.: The mechanism of uterine inhibitory action of relaxin-containing ovarian extracts. J. Pharmacol. exp. Ther. 138, 82–87 (1962a).

    PubMed  CAS  Google Scholar 

  • — —The effect of altering the catecholamine content of the uterus on the rate of contractions and the sensitivity of the myometrium to relaxin. J. Pharmacol. exp. Ther. 138, 88–95 (1962b).

    PubMed  CAS  Google Scholar 

  • Rüsse, M., Marshall, J. M.: Effect of hypogastric nerve stimulation on the uterus of the guinea pig in vivo. Fed. Proc. 29, 639 (1969).

    Google Scholar 

  • Sandberg, F., Ingelman-Sunberg, A., Lindgren, L., Ryden, G.: In vitro studies of the motility of the human fallopian tube. Acta obstet. gynec. scand. 39, 506–516 (1960).

    PubMed  CAS  Google Scholar 

  • Sauer, J., Jett-Jackson, C. E., Reynolds, S. R. M.: Reactivity of the uterus to presacral nerve stimulation and to epinephrine, pituitrin and pilocarpine administration during certain sexual states in the anesthetized rabbit. Amer. J. Physiol. 111, 250–256 (1935).

    CAS  Google Scholar 

  • Sawyer, W. H.: Neurohypophyseal secretions and their origin. In: Advances in neuro-endocrinology. Urbana: Univ. Illinois Press 1963.

    Google Scholar 

  • Schild, H. O.: The action of isoprenaline in the depolarized rat uterus. Brit. J. Pharmacol. 31, 578–592 (1967).

    PubMed  CAS  Google Scholar 

  • Schofield, B. M.: The innervation of the cervix and cornu uteri in the rabbit. J. Physiol. (Lond.) 117, 317–328 (1952).

    CAS  Google Scholar 

  • — The influence of the ovarian hormones on myometrial behaviour in the intact rabbit. J. Physiol. (Lond.) 129, 289–304 (1955).

    CAS  Google Scholar 

  • Setekleiv, J.: Uterine motility of the estrogenized rabbit. III. Response to hypogastric and splanchnic nerve stimulation. Acta physiol. scand. 62, 137–149 (1964).

    PubMed  CAS  Google Scholar 

  • Shore, P., Olin, J. S.: Identification and chemical assay of norepinephrine in brain and other tissues. J. Pharmacol. exp. Ther. 122, 295–300 (1958).

    PubMed  CAS  Google Scholar 

  • Silva, D. G.: The ultrastructure of the myometrium of the rat with special reference to the innervation. Anat. Rec. 158, 21–34 (1966).

    Google Scholar 

  • Sjöberg, N. O.: The adrenergic transmitter of the female reproductive tract: distribution and functional changes. Acta. physiol. scand., Suppl. 305, 5–26 (1967).

    Google Scholar 

  • — Increase in transmitter content of adrenergic nerves in the reproductive tract of female rabbits after oestrogen treatment. Acta endocr. (Kbh.) 57, 405–413 (1968).

    Google Scholar 

  • Sjöstrand, N. O.: The adrenergic innervation of the vas deferens and the accessory male genital glands. Acta. physiol. scand. 65, 9–77 (1965).

    Google Scholar 

  • Sobotta, J.: Beiträge zur vergleichenden Anatomie und Entwicklungsgeschichte der Uterusmuskulatur. Arch. mikr. Anat. 38, 52–100 (1891).

    Google Scholar 

  • Speden, R. S.: Electrical activity of single smooth muscle cells of the mesenteric artery produced by splanchnic nerve stimulation in the guinea-pig. Nature (Lond.) 202, 193–194 (1964).

    CAS  Google Scholar 

  • Spratto, G. R., Miller, J. W.: The effect of various estrogens on the weight, catecholamine content and rate of contractions of rat uteri. J. Pharmacol. exp. Ther. 161, 1–6 (1968a).

    PubMed  CAS  Google Scholar 

  • — — An investigation of the mechanism by which estradiol-17 β elevates the epinephrine content of the rat uterus. J. Pharmacol. exp. Ther. 161, 7–13 (1968b).

    PubMed  CAS  Google Scholar 

  • Stjärne, L., Lishajko, F.: Comparison of spontaneous loss of catecholamines and ATP in vitro from isolated bovine adrenomedullary, vesicular gland, vas deferens and splenic nerve granules. J. Neurochem. 13, 1213–1216 (1966).

    PubMed  Google Scholar 

  • Stroup, P. E.: Influence of epinephrine on uterine contractility. Amer. J. Obstet. Gynec. 84, 595–601 (1962).

    PubMed  CAS  Google Scholar 

  • Sullivan, S. F., Marshall, J. M.: A quantitative evaluation of the effects of catecholamines on the human myometrium in vitro. Amer. J. Obstet. Gynec. (in press) (1969).

    Google Scholar 

  • Swedin, G., Brundin, J. O.: Distribution of noradrenaline in the genital organs of the female rat with a remark on dopamine in the cervix and vagina. Experientia (Basel) 24, 1015–1016 (1968).

    CAS  Google Scholar 

  • Theobald, G. W.: Nervous control of uterine activity. Clin. Obstet. Gynec. 11, 15–33 (1968).

    PubMed  CAS  Google Scholar 

  • Tothill, Anne: Investigation of adrenaline reversal in the rat uterus by the induction of resistance to isoprenaline. Brit. J. Pharmacol. 29, 291–301 (1967).

    PubMed  CAS  Google Scholar 

  • Tsai, T. H., Fleming, W. W.: The adrenotropic receptors of the cat uterus. J. Pharmacol. exp. Ther. 143, 268–272 (1964).

    PubMed  CAS  Google Scholar 

  • Vanov, S., Vogt, M.: Catecholamine-containing structures in the hypogastric nerves of the dog. J. Physiol. (Lond.) 168, 939–944 (1963).

    CAS  Google Scholar 

  • Varagić, V.: An isolated hypogastric-nerve-uterus preparation, with observations on the hypogastric transmitter. J. Physiol. (Lond.) 132, 92–99 (1956).

    Google Scholar 

  • Vogt, M.: Transmitter released in the cat uterus by stimulation of the hypogastric nerves. J. Physiol. (Lond.) 179, 163–171 (1965).

    CAS  Google Scholar 

  • Wansbrough, H., Nakanishi, H., Wood, C.: Effect of epinephrine on human uterine activity in vitro and in vivo. Obstet. and Gynec. 30, 779–789 (1967).

    CAS  Google Scholar 

  • Willems, J. L., Schaepdryver, A. F. de: Adrenergic receptors in the oestradiol and allyl-oestrenol dominated rabbit uterus. Arch. int. Pharmacodyn. 161, 269–274 (1966).

    PubMed  CAS  Google Scholar 

  • Wurtman, R. J., Axelrod, J., Kopin, I. J.: Uterine epinephrine and blood flow in pregnant and postparturient rats. Endocrinology 73, 501–503 (1963).

    PubMed  CAS  Google Scholar 

  • — — Potter, L. T.: The disposition of catecholamines in the rat uterus and the effect of drugs and hormones. J. Pharmacol. exp. Ther. 144, 150–155 (1964).

    PubMed  CAS  Google Scholar 

  • — Chu, W., Axelrod, J.: Relation between the estrous cycle and the binding of catecholamines in the rat uterus. Nature (Lond.) 198, 547–548 (1963).

    CAS  Google Scholar 

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  1. Division of Biological and Medical Sciences, Brown University, 02912, Providence, R. I.

    Jean M. Marshall

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Marshall, J.M. (1970). Adrenergic innervation of the female reproductive tract: Anatomy, physiology and pharmacology. In: Reviews of Physiology, Biochemistry and Experimental Pharmacology. Ergebnisse der Physiologie, biologischen Chemie und experimentellen Pharmakologie, vol 62. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0111421

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