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Amino acid sequence homology of factor c produced by Streptomyces griseus with regulatory proteins of zinc finger type

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Abstract

Factor C is a regulatory protein produced by Streptomyces griseus 45H. Factor C-like antigen can be detected in the most diverse species examined. It is also present in human serum with an average of 219.4 U/ml of narrow dispersion. The level of factor C-like antigen shows an increase in the sera of patients with different hepatic disorders (341 U/ml), some values being 3–7 times higher than normal (600–1500 U/ml). Correlation was found between the elevated antigen levels and the amount of the bilirubin in the sera of patients with liver cirrhosis.

Amino acid sequence homology was found between factor C and zinc finger motifs of several known DNA binding proteins. In fact, factor C was successfully bound to and eluted from a Zn2+ affinity column. Our data show that factor C is probably a zinc finger type DNA binding protein.

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Authors and Affiliations

  1. Institute of Biology, University Medical School, Nagyerdei krt. 98, H-4012, Debrecen, Hungary

    F. Szeszák, S. Vitális & S. Biró

  2. Department of Infectious Diseases of County Hospital, Debrecen, Hungary

    L. Dalmi

Authors
  1. F. Szeszák
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  2. S. Vitális
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  3. S. Biró
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  4. L. Dalmi
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Dedicated to the memory of Professor Gábor Szabó.

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Szeszák, F., Vitális, S., Biró, S. et al. Amino acid sequence homology of factor c produced by Streptomyces griseus with regulatory proteins of zinc finger type. BIOLOGIA FUTURA 48, 265–273 (1997). https://doi.org/10.1007/BF03543198

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  • DOI: https://doi.org/10.1007/BF03543198

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