Abstract
Most of the clinical data on the safety profile of desmopressin (DDAVP), which is an effective treatment for both polyuric conditions and bleeding disorders, originate from studies on the tailoring of drug treatment, whereas few reports exist describing severe side effects secondary to drug-drug interaction. We herein describe a case of severe hyponatremia complicated by seizure and coma due to the intake of non-steroidal anti-inflammatory drugs (NSAIDs) in a patient on DDAVP replacement therapy for central diabetes insipidus (DI). A 50-yr-old Caucasian man, with congenital central DI, developed an episode of generalized tonic-clonic seizure, resulting in coma immediately after being admitted to the Emergency Unit for weakness and emesis. Based on his medical history and clinical findings, water intoxication secondary to ketoprofen intake (200 mg/day for the last 3 days) concomitant with DDAVP replacement therapy (Minirin® 60 mcg 4 tablets a day) was hypothesized as being the cause of the severe euvolemic hypotonic hyponatremia (natremia 113 mEq/l, plasma osmolality 238 mOsm/Kg). After standard emergency procedures, appropriate gradual restoration of serum sodium levels to the normal range was achieved in 72 hours. Hydratation was maintained according to water excretion and desmopressin therapy was re-introduced. We discuss this case report in the context of the published literature. The present report first highlights the potentially life-threatening side effects associated with over-the-counter NSAIDs during DDAVP replacement therapy for central DI. Risks and benefits of co-treatment should be carefully considered and therapeutic alternatives to NSAIDs should be recommended to patients with central DI in order to improve DDAVP safety.
Similar content being viewed by others
References
Vande Walle J, Stockner M, Racs A, et al, 2007 Desmopressin 30 years in clinical use: a safety review. Curr Drug Saf 2: 232–238.
Juul KV, Bichet DG, Nørgaard JP, 2011 Desmopressin duration of antidiuretic action in patients with central diabetes insipidus. Endocrine 40: 67–74.
Juul KV, Klein BM, Sandström R, et al, 2011 Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol 300: F1116–1122.
Liu J, Sharma N, Zheng W, et al, 2011 Sex differences in vasopressin V2 receptor expression and vasopressin-induced antidiuresis. Am J Physiol Renal Physiol 300: 433–440.
Kim RJ, Malattia C, Allen M, et al, 2004 Vasopressin and desmopressin in central diabetes insipidus: adverse effects and clinical considerations. Pediatr Endocrinol Rev 2: Suppl 1: 115–123.
Bleumink GS, Feenstra J, Sturkenboom MC, et al, 2003 Nonsteroidal anti-inflammatory drugs and heart failure. Drugs 63: 525–534.
Odeh M, Oliven A, 2011 Coma and seizures due to severe hyponatremia and water intoxication in an adult with intranasal desmopressin therapy for nocturnal enuresis. J Clin Pharmacol 41: 582–584.
Müller D, Roehr CC, Eggert P, 2004 Comparative tolerability of drug treatment for nocturnal enuresis in children. Drug Saf 27: 717–727.
Kelleher HB, Henderson SO, 2006 Severe hyponatremia due to desmopressin. J Emerg Med 30: 45–47.
Rembratt A, Riis A, Norgaaed JP, 2006 Desmopressin treatment in nocturia: an analysis of risk factor for hyponatremia. Neurourol ürodyn 25: 105–109.
Callréus T, Ekman E, Andersen M, 2005 Hyponatremia in elderly patients treated with desmopressin for nocturia: a review of a case series. Eur J Clin Pharmacol 61: 281–284.
Ljung R, 2008 Use of desmopressin and concomitant use of potentially interacting drugs in elderly patients in Sweden. Eur J Clin Pharmacol 64: 439–444.
Francis JD, Leary T, Niblett DJ, 1999 Convulsions and respiratory arrest in association with desmopressin administration for the treatment of a bleeding tonsil in a child with borderline haemophilia. Acta Anaesthesiol Scand 43: 870–873.
Shindel A, Tobin G, Klutke C, 2002 Hyponatremia associated with desmopressin for the treatment of nocturnal polyuria. Urology 60: 344.
Gomez Garcia EB, Ruitenberg A, Madretsma GS, et al, 2003 Hyponatraemic coma induced by desmopressin and ibuprofen in a woman with von Willebrand’s disease. Haemophilia 9: 232–234.
Baggaley E, Nielsen S, Marples D, 2010 Dehydratation-induced increase in aquaporin-2 protein abundance is blocked by nonsteroidal anti-inflammatory drugs. Am J Physiol Renal Physiol 298: 1051–1058.
Breyer MD, Breyer RM, 2011 G protein-coupled prostanoid receptors and the kidney. Ann Rev Physiol 63: 579–605.
Zelenina M, Christensen BM, Palmér J, et al, 2000 Prostaglandin E(2) interaction with AVP: effects on AQP2 phosphorylation and distribution. Am J Physiol Renal Physiol 278: F388–394.
Olesen ETB, Rützler MR, Moeller HB, et al, 2011 Vasopressin-independent targeting of aquaporin-2 by selective E-prostanoid receptor agonists alleviates nephrogenic diabetes insipidus. PNAS 108: 12949–12954.
Odeberg JM, Callréus T, Lundin S, et al, 2004 A pharmacokinetic and pharmacodynamic study of desmopressin: evaluating sex differences and the effect of pre-treatment with piroxicam and further validation of an indirect model. J Pharm Pharmacol 56: 1389–1398.
Sherlock M, Thompson CJ, 2010 The syndrome of inappropriate antidiuretic hormone: current and future management options. Eur J Endocrinol 162: Suppl 1: 13–18.
Schrier RW, Bansal S, 2008 Diagnosis and management of hyponatremia in acute illness. Curr Opin Crit Care 14: 627–634.
Decaux G, Soupart A, Vassart G, 2008 Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet 371: 1624–1632.
Verbalis JG, Goldsmith SR, Greenberg A, et al, 2007 Hyponatremia treatment guidelines 2007: expert panel recommendations. Am J Med 120: 11 Suppl 1: 1–21.
Nemergut EC, Zuo Z, Jane JA Jr, et al, 2005 Predictors of diabetes insipidus after transsphenoidal surgery: a review of 881 patients. J Neurosurg 103: 448–454.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Verrua, E., Mantovani, G., Ferrante, E. et al. Severe water intoxication secondary to the concomitant intake of non-steroidal anti-inflammatory drugs and desmopressin: a case report and review of the literature. Hormones 12, 135–141 (2013). https://doi.org/10.1007/BF03401295
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03401295