Abstract
Lipoprotein lipase activity, total serum cholesterol and triglycerides, HDL cholesterol were determined before and after two weeks of treatment with a low dose of an α1-blocking agent (prazosin) or of a β-adrenergic-blocking drug (metoprolol). Lipoprotein lipase activity was almost doubled after prazosin (p < 0.02) and practically unchanged after metoprolol, at a time and at a drug dosage when only minor changes in blood pressure and serum lipids were detectable. HDL cholesterol was slightly but significantly increased after prazosin (p < 0.05). Heart rate was increased after prazosin (p<0.05) and decreased after metoprolol (p<0.01).
Similar content being viewed by others
References
Van Brummelen P. The relationship of intrinsic sympathomimetic activity for beta blocker induced changes in plasma lipids. J. Cardiovasc. Pharmacol. 5 (Suppl. 1): 551, 1983.
Ferrara L.A., Marotta T., Scilla A., Mastranzo Strazzullo P., Mancini M. Effects of oxprenolol and metoprolol on serum lipid concentration. Eur. J. Clin. Pharmacol. 26: 331, 1984.
Leren P., Foss O.P., Helgeland A., Hjermann I., Holme I., Lund Larsen P.G. Effect of propranolol and prazosin on blood lipids. The Oslo study. Lancet 2: 4, 1980.
Takabatake T., Ohta H., Mackawa M., Yamamoto Y., Ishida Y., Hara H., Hattori N. Effects on long term Prazosin therapy on lipoprotein metabolism in hypertensive patients. Am. J. Med. 76 (Suppl. 2A): 113, 1984.
Ferrara L.A, Marotta T., Rubba P., De Simone B., Leccia G., Soro S., Mancini M. Effects of alpha-adrenergic and beta-adrenergic receptor blockade on lipid metabolism. Am. J. Med. 80:104, 1986.
Oriente P., Di Marino, Mastranzo P., lovine C., Patti L. Simultaneous determination of cholesterol and triglycerides in serum and lipoprotein fractions with enzymatic automated methods. In: Burlina A., Galzigna L. (Eds.), Clinical Enzymiology. Symposium 2, Piccin Medical Books, Padova, 1979.
Kostner G.M. Enzymatic determination of cholesterol in high density lipoprotein fractions prepared by polyanion precipitation. Clin. Chem. 22:695, 1976.
Boberg J. Quantitative determination of heparin-released lipoprotein lipase activity in human plasma. Lipids 5:452,1970.
Vessby B., Boberg J. Lypolitic activity in post-heparin plasma in man measured with different substrate emulsions. Clin. Sci. Mol. Med. 54: 201, 1978.
Dixon W.J., Massey F.J. Introduction to Statistical Analysis. Mc Graw-Hill, New York, 1969.
Cryer A. Comparative biochemestry and physiology of Lipoprotein Lipase. In: Borensztajn J. (Ed.), Lipoprotein Lipase. Evener Publishers Inc., Chicago, 1987, p. 277.
Fain J.N., Garcia-Sainz J.A. Adrenergic regulation of adipocyte metabolism. J. Lipid Res. 24: 945, 1983.
Eckel R.H. Adipose tissue lipoprotein lipase. In: Borensztajn J. (Ed.), Lipoprotein Lipase. Evener Publishers, Inc., Chicago, 1987, p. 79.
Uchard S.J., Lattanzio F.A., Rubin R.W., Pressman B.C. Stimulation on cathecolamine secretion from cultured chromaggin cells by an ionophore-mediated rise in intracellular sodium. J. Cell. Biol. 94: 531, 1982.
Vannier C., Ez-Zoubrin A., Etienne J., Negrel R., Ailhaud G. Maturation and secretion on Lipoprotein Lipase in cultured adipose cells. J. Biol. Chem. 260: 4424, 1985.
Chajek-Shaul T., Friedman G., Knobler H., Stein O., Etienne J., Stein Y. Importance of the different steps of glycosilation for the activity and secretion of lipoprotein lipase in rat preadipocytes studied with monensin and tunicamycin. Biochem. Biophys. Acta 827: 123, 1985.
Christiansen N.J. Catecholamines and diabetes mellitus. Diabetologia 16: 211, 1979.
Rubba P., Capaldo B., Falanga A., Caprio S., Rivellese A., Riccardi G., Mancini M. Plasma lipoproteins and lipoprotein lipase in young diabetics with and without ketonuria. J. Endocrinol. Invest. 8: 433, 1985.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rubba, P., De Simone, B., Marotta, T. et al. Adrenergic blocking agents and lipoprotein lipase activity. J Endocrinol Invest 12, 119–122 (1989). https://doi.org/10.1007/BF03349937
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF03349937