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Total digoxin-like immunoreactive factor(s) in healthy population, uncomplicated term pregnancies and neonates

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Abstract

Free digoxin-like immunoreactive factors) (DLIF) which may have a homeostatic role, as documented in different physiological conditions, but is generally undetectable in plasma from normal population. Total digoxin-like immunoreactive factor(s) (protein bound and free) can be estimated after plasma is heated. In this study, total digoxin-like immunoreactive factor(s) as measured in plasma in a well defined control population and compared to healthy term pregnant women and neonates, categories known to be associated with increased free digoxin-like. immunoreactive factors) concentrations. The mean level of this factors) in the control group was 706 ± 129 pg digoxin equivalent/ml (pg/ml) and was unaffected by age and sex. Significantly increased levels of total digoxin-like immunoreactive factor(s) were found in pregnant women and neonates (928 ± 127 and 1242 ± 367 pg/ml, respectively). We conclude that levels of total digoxin-like immunoreactive factor(s) are increased in term pregnancies and neonates, similarly to its free form. However total digoxin-like immunoreactive factor(s) is detected in the normal population as a plasma component, contrary to its free form, which is generally undetectable.

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Authors and Affiliations

  1. Department of Medicine A and Clinical Pharmacology Unit, and Gynecology/Obstetrics B, Rambam Medical Center and Faculty of Medicine, Technion, Haifa, Israel

    N. Krivoy M.D. & G. Alroy

Authors
  1. N. Krivoy M.D.
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  2. P. Jakobi
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  3. E. Paldi
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  4. G. Alroy
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Supported in part by a Grant No. 180-0927 from the Technion (Israel Institute of Technology) Haifa, Israel.

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Krivoy, N., Jakobi, P., Paldi, E. et al. Total digoxin-like immunoreactive factor(s) in healthy population, uncomplicated term pregnancies and neonates. J Endocrinol Invest 13, 9–12 (1990). https://doi.org/10.1007/BF03348569

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  • DOI: https://doi.org/10.1007/BF03348569

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