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The relation of adiponectin and tumor necrosis factor α levels between endothelial nitric oxide synthase, angiotensin-converting enzyme, transforming growth factor β, and tumor necrosis factor α gene polymorphism in adrenal incidentalomas

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Abstract

Objective: The aim of our study was to demonstrate demographic characteristics, presence of inflammatory markers, distribution of angiotensin-converting enzyme (ACE), tumor necrosis factor (TNF), endothelial nitric oxide synthase (eNOS) genotypes and relations among these parameters in these patients and control subjects. Research design and methods: Study samples were collected from 50 patients with adrenal mass and 30 control groups. The eNOS, ACE, TNF-α, transforming growth factor (TGF)-β genes polymorphisms, TNF-α, adiponectin levels were analysed in 50 unrelated Turkish patients with a diagnosis of adrenal incidentaloma (AI). Results: There was statistically significant difference between TNF-α levels of patient and controls (p=0.048). We have not detected the connection between TGF-β, TNF-α, ACE, eNOS gene polymorphism with serum TNF-α and adiponectin levels. In this study, we demonstrated that there were significant differences for ACE genotypes in the patients when compared to the controls (p<0.05). The percentages of the ID, DD, II genotypes for ACE gene polymorphism in the patients group were 30.0, 13.0, 7.0%, respectively. Conclusions: According to different cases of eNOS, TGF-β, ACE, and TNF-α gene genotypes; no statistical significant difference was found between basal cortisol, ACTH, DHEAS, metanephrine, renin, aldosterone, normetanephrine, 17-hydroxyprogesterone, 1 mg low-dose dexamethasone suppression test-cortisol response and AI size. In this study, I/D genotype was determined to be statistically higher in ACE gene in patients with AI (p=0.014).

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Authors and Affiliations

  1. Division of Internal Medicine, Division of Endocrinology, Ege University Hospital, Izmir, Turkey

    E. Harman, M. Karadeniz MD, A. Zengi, S. Cetinkalp, A. G. Ozgen, F. Saygili & C. Yilmaz

  2. Division of Medical Biology, Ege University Hospital, Izmir

    C. Biray & C. Gündüz

  3. Division of Moleculer Medicine Laboratuar, Ege University Hospital, Izmir

    A. Berdeli

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  1. E. Harman
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Harman, E., Karadeniz, M., Biray, C. et al. The relation of adiponectin and tumor necrosis factor α levels between endothelial nitric oxide synthase, angiotensin-converting enzyme, transforming growth factor β, and tumor necrosis factor α gene polymorphism in adrenal incidentalomas. J Endocrinol Invest 32, 881–888 (2009). https://doi.org/10.1007/BF03345766

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