Abstract
N-terminal pro-atrial natriuretic peptide [proANP(1–98)] has been extensively investiga-ted in patients with chronic heart failure and ishemic heart disease. It is found to be a better marker of cardiac dysfunction than atrial natriuretic peptide (ANP). The possible involvement of proANP(1–98) in cardiac depression caused by sepsis has not been studied yet. Therefore, we analyzed atrial plasma concentration of proANP(1–98) in 17 septic patients with hemodynamic variables measured or calculated using pulmonary artery catheter. The results of altogether 96 measurements show a significant negative correlation of proANP(1–98) and cardiac index (p<0.024), oxygen delivery (p<0.03) and oxygen consumption (p<0.03). There is also a positive correlation with pulmonary vascular resistance (p<0.03). ProANP(1–98) is significantly higher in patients who developed acute respiratory distress syndrome (ARDS) (p<0.001). This study implies that proANP(1–98) is a possible novel hormone marker of cardiac depression caused by sepsis that could be used for prediction of ARDS.
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Mazul-Sunko, B., Zarkovic, N., Vrkic, N. et al. Pro-atrial natriuretic peptide hormone from right atria is correlated with cardiac depression in septic patients. J Endocrinol Invest 24, RC22–RC24 (2001). https://doi.org/10.1007/BF03343878
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DOI: https://doi.org/10.1007/BF03343878