Summary
Family and twin studies showed that besides HLA- B27 other genetic factors are of significance for the pathogenesis of ankylosing spondylitis, reactive arthritis or acute anterior uveitis. There are up to now no strong indications that any subtype of B27 is especially associated with these diseases. Also the indications that B2703 and B2706 are protective should be further substantiated. HLA- B27/HLA- B60 heterozygotes have a three times higher risk to develop ankylosing spondylitis as persons with another B type opposite B27. Haplotype studies made it unlikely that the other genetic factors are situated on chromosome 6p. Studies on 23 other genetic MÄRKER systems were all negative in this respect.
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References
Tiwari, J.L., Terasaki, P.I. HLA and disease associations. New York, Springer Verlag,1985
Linssen, A. B27+ disease versus B27- disease. Scand J Rheumatology 1990, Suppl 87, 111–119.
Vander Linden, J.M.J.P., Valkenburg, H.A., De Jong, B.A., Cats, A. The risk of developing ankylosing spondylitis in HLA-B27 positive individuals. Arthritis Rheum 1984, 27, 241–249.
Linssen, A., Rothova, A., Valkenburg, H.A., Dekker-Saeys, A.J., Luyendijk, L., Kijlstra, A., Feltkamp, T.E.W. The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27. Invest Ophthalmol Vis Sci 1992, 32, 2568–2578.
Derhaag, P.J.F.M., Linssen, A. Broekema, N, De Waal, L.P., Feltkamp, T.E.W. A family study on the inheritance of HLA-B27 positive acute anterior uveitis. Am J Ophthalmol 1988,105, 603–606.
Jarvinen, P. Occurrence of ankylosing spondylitis in nationwide series of twins. Arthritis Rheum 1995, 38, 381–383.
Hildebrand, W.H., Domena, J.D., Shen, S.Y., Marsh, S.G., Bunce, M., Guttridge, M.G., Darke, C, Parham, P. The HLA-B7Qui antigen is encoded by a new subtype of HLA-B27 (B*2708). Tissue Antigens 1994, 44, 47–51.
Del Porto, P., D’Amato, M., Fiorillo, M.T., Tuosto, L., Piccolella, E., Sorrentino, R. Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma-delta T cell clone. J Immunology 1994,153, 3093–4000.
Breur-Vriesendorp, B.S., Dekker-Saeys, A.J., Ivanyi, P. Distribution of HLA-B27 subtypes in patients with ankylosing spondylitis: The disease is associated with a common determinant of various B27 molecules. Ann Rheum Dis 1987, 46, 353–356.
Derhaag, P.J.F.M., De Waal, L.P, Linssen, A., Feltkamp, T.E.W Acute anterior uveitis and HLA-B27 subtypes. Invest Ophthalmol Vis Sci 1988, 29,1137–1140.
Reveille, J.D., Appleyard, J., Lan, J.-L., Ahearn, J.M., Choo, S.Y., Arnett, EC. HLA-B27 subtypes in patients with spondylarthropathy. Rev Esp Reumatol 1993, 20(Suppl), 1, 172.
López-Larrea, C, Sujirachato, K., Mehra, N.K., Chiewsilp, P., Isarangkura, D., Kanga, U., Dominingez, O., Coto, E., Pena, M., Setien, F, Gonzalez-Roces, S. HLA-B27 subtypes in Asian patients with ankylosing spondylitis. Tissue Antigens 1995, 45, 169–176.
Hill, A.VS., Allsopp, C.E.M., Kwiatkowski, D., Anstey, N.M., Greenwood, B.M., McMichael, A.J. HLA class I typing by PCR: HLA-B27 and an African B27 subtype. Lancet 1991, 337, 640–642.
Mijiyawa, M. Spondylarthropathy in patients attending the rheumatology unit of Lome hospital. J Rheumatol 1993,20,1167–1169.
Robinson, WP, Van der Linden, S.M., Khan, M.A., Rentsch, H.-U., Cats, A., Russell, A., Thomson, G. HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients. Arthritis Rheum 1989, 32,1135–1141.
Derhaag, P.J.F.M., Van der Horst, A.R., De Waal, L.P, Feltkamp, T.E.W HLA-B27+ acute anterior uveitis and other antigens of the major histocompatibility complex. Invest Ophthalmol Vis Sci 1989, 30, 2160–2164.
Reveille, J.D., Suarez-Almazor, M.E., Russell, A.S., Go, R.C., Appleyard, J., Barger, B.O., Acton, R.T., Koopman, W.J., McDaniel, D.O. HLA in ankylosing spondylitis: is HLA-B27 the only MHC gene involved in disease pathogenesis? Semin Arthritis Rheum 1994, 23, 295–309.
Islam, S.M.M., Numaga, J., Mitsui, H., Maeda, H. Immunology of AAU in AS patients. Immunology Today 1994, 15, 595.
Feltkamp, T.E.W. Immunology of AS in AAU patients. Immunology Today 1994,15, 595.
Lochead, J.A., Chalmers, I.M., Marshall, W.H., Larsen, B., Skanes, V.M., Payne, R.H., Barnard JM,. HLA-B27 haplotypes in family studies of ankylosing spondylitis. Arthritis Rheum 1983, 26,1011–1016.
Reveille, J.D., Suarez Almazor, M.E., Russell, A.S., Go, R.C.P., Appleyard, J., Barger, B.O., Acton, R.T., Koopman, W.J., McDaniel, D.O. HLA in ankylosing spondylitis: is HLA-B27 the only MHC gene involved in disease pathogenesis? Sem Arthritis Rheum 1994, 23, 295–309.
Verjans, G.M.G.M., Brinkman, B.M.N., van Doornik, C.E.M., Kijlstra, A., Verweij, C.L. Polymorphism of tumor necrosis factor -alpha at position 308 in relation to ankylosing spondylitis. Clin Exp Immunol 1994, 97, 45–47.
Linssen, A., Rothova, A., Broekema, N., Derhaag, P.J.F.M., Luyendijk, L., De Lange, G.G., Van Eede, P.H., Van Leeuwen, A.M., Frants, R., Kruit, P.J., Baarsma, G.S., Kijlstra, A., Feltkamp, T.E.W. Genes of chromosome 14q and their role in the pathogenesis of HLA-B27 associated diseases. Clin Exp Rheumatol 1987,5/s-l, 89–95.
De Jongh, B.M., Van der Linden, S.M., Volkers, W.S., Cats, A. Genetics of non-HLA MÄRKER genes in HLA-B27-positive and -negative ankylosing spondylitis families. Scand J Rheumatology 1990, Suppl 87, 127–130.
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Feltkamp, T.E.W. Non-HLA-B27 Genetic Factors in HLA-B27 Associated Diseases. Clin Rheumatol 15 (Suppl 1), 40–43 (1996). https://doi.org/10.1007/BF03342644
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DOI: https://doi.org/10.1007/BF03342644