Abstract
The study of the neuroendocrine changes occurring in aging may give information about the CNS functions, and also explain the impaired plasticity of the aged organism. In 16 elderly women and in 14 young controls, the circadian rhythms of plasma melatonin, GH, PRL, ACTH and cortisol, and of oral temperature were simultaneously studied. The plasma cortisol circadian rhythm was also evaluated after DXM administration (1 mg orally at 23:00). The circadian profile of all the bioperiodic functions evaluated was clearly flattened in elderly subjects, and an impairment of the hormonal nocturnal secretion of GH, PRL and melatonin was apparent in elderly subjects when compared to young controls. The plasma ACTH levels throughout the 24-hour cycle were significantly higher in elderly than in young subjects. The cortisol circadian profile exhibited significantly higher values in the evening- and night-time in elderly subjects, compared to young controls; the cortisol nadir values were significantly age-related. A reduction of the sensitivity to DXM inhibition occurred in the elderly group. Both the selective impairment of nocturnal melatonin secretion, and the reduction of hypothalamo-pituitary-adrenal (HPA) sensitivity to steroid feedback might be considered as markers of aging brain. The neuroendocrine alterations of physiological aging may be ascribable to both the structural and neurochemical changes occurring in the CNS.
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Reiter R.J.: Pineal and associated neuroendocrine rhythms. Psychoneuroendocrinology 1: 255–263, 1976.
Axelrod J.: The pineal gland: a neurochemical transducer. Science 184: 1341–1344, 1974.
Grad B.R., Rozencwaig R.: The role of melatonin and serotonin in aging: update. Psychoneuroendocrinology 18: 283–295, 1993.
Halberg F.: Chronobiology. Ann. Rev. Physiol. 31: 675–725, 1969.
Bingham C., Arbogast B., Guillaume G.C., Lee J.K., Halberg F.: Inferential statistical methods for estimating and comparing cosinor parameters. Chronobiologia 9: 397–439, 1982.
Carrol B.J., Feinberg M., Gerden J.F.: A specific laboratory test for the diagnosis of melanchonia: standardization, validation and clinical utility. Arch. Gen. Psychiatry 38: 15–22, 1981.
Scheving L.E., Roig C., Halberg F., Pauly J.E., Hand E.A.: Circadian variations in residents of a “senior citizens” home. In: Scheving L.E., Halberg F., Pauly J.E. (Eds.), Chronobiology. Igaku Shoin Ltd., Tokio, 1974, pp. 353–357.
Touitou Y., Reinberg A., Bogdan A., Auzeby A., Beck H., Touitou C.: Age-related changes in both circadian and seasonal rhythms of rectal temperature, with special reference to senile dementia of Alzheimer type. Gerontology 32: 110–118, 1986.
Reinberg A., Smolensky M.: Chronobiology and thermoreg-ulation. Pharmacol. Ther. 22: 425–464, 1983.
Martin J.B., Reichlin S.: Clinical neuroendocrinology, ed. 2, F.A. Davis Co., Philadelphia, 1987, pp. 379–421.
Halberg F.: Biological rhythms, hormones and aging. In: Vernadakis A., Timiras P.S. (Eds.), Hormones in development and aging. S.P. Medical and Scientific Books, New York, 1982, pp. 451–476.
Touitou Y., Fevre M., Bogdan A., Reinberg A., Touitou C., Beck H.: Age and mental health-related circadian rhythms of plasma levels of melatonin, prolactin, luteinizing hormone and follicle-stimulating hormone in man. J. Endocrinol. 91: 467–475, 1981.
Tapp E., Huxley M.: The histological appearance of the human pineal gland from puberty to old age. J. Pathol. 108: 137–144, 1972.
Brown G.M., Young S.N., Gauthier S., Tsui H., Grota L.J.: Melatonin in human cerebrospinal fluid in daytime; its origin and variation with age. Life Sci. 25: 929–936, 1979.
Iguchi H., Kato K.J., Ibayashi H.: Age-dependent reduction in serum melatonin concentrations in healthy human subjects. J. Clin. Endocrinol. Metab. 55: 27–30, 1982.
Sack R.L., Lewi A.J., Erb D.L., Voliner W.M., Singer C.M.: Human melatonin production decreases with age. J. Pineal Res. 3: 379–388, 1986.
Thomas D.R., Miles A.: Melatonin secretion and age. Biol. Psychiatry 25: 363–369, 1989.
Sharma M., Palacios-Bois J., Schwartz G., Iksandar H., Thakur M., Quirion R., Nair N.P.V.: Circadian rhythms of melatonin and cortisol in aging. Biol. Psychiatry 25: 305–319, 1989.
Ferrari E., Solerte S.B., Dori D., Magri F., Fioravanti M., Bossolo P.A.: Changes of the circadian pattern of plasma melatonin related to aging. In: Reinberg A., Smolensky M., Labreque G. (Eds.), Annual Review Chronopharmacology. Pergamon Press, Oxford, New York, 1990, Vol. 7, pp. 7374.
Greenberg L., Weiss B.: Beta-adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to develop supersensitivity. Science 201: 61–63, 1978.
Ebstein R.B., Stessman J., Eliaikim R., Menczel J.: The effect of age on beta-adrenergic function in man: a review. Isr. J. Med. Sci. 21: 302–311, 1985.
Scarpace P.J., Abrass I.B.: Alpha and beta-adrenergic receptor function in the brain during senescence. Neurobiol. Aging 9: 53–58, 1988.
Hornykiewicz O.: Dopamine changes in the aging human brain: functional considerations. In: Agnoli A., Crepaldi G., Spano P.F., Trabucchi M. (Eds.), Aging brain and ergot alkaloids. Raven Press, New York, 1983, pp. 9–14.
Petkov V.D., Petkov V.V., Stancheva S.L.: Age-related changes in brain neurotransmission. Gerontology 34: 14–21, 1988.
Finkelstein W.J., Roffwarg H.P., Boyar R.M., Kream J., Hellman L.: Age-related change in the twenty-four hour spontaneous secretion of growth hormone. J. Clin. Endocrinol. Metab. 35: 665–670, 1972.
Rudman D., Kutner M.H., Rogers C.M., Lubin M.F., Fleming G.A., Bain R.P.: Impaired growth hormone secretion in the adult population. J. Clin. Invest. 67: 1361–1369, 1981.
Rudman D., Rao U.M.P.: The Hypothalamic-Growth Hor-mone-Somatomedin C axis: the effect of aging. In: Morley J., Korenman S.G. (Eds.), Endocrinology and Metabolism in the Elderly. Blackwell Scient. Publ., Boston, 1992, pp. 35–57.
Timiras P.S.: Neuroendocrine theories of aging: homeostasis and stress. In: Vernadakis A., Timiras P.S. (Eds.), Hormones in development and aging. Spectrum Publications Inc., Jamaica, New York, 1982, pp. 551–586.
Zakria F., Stern N., McGinty D., Beahm E., Littner M., Sowers J.R.: Effect of age on circadian rhythm of prolactin in normal men. Chronobiologia 15: 219–222, 1988.
VanCoeverden A., Mockel J., Laurent E., Kerkhofs M., L’Hermite-Baleriaux M., Decoster C., Neve P., Van Cauter E.: Neuroendocrine rhythms and sleep in aging men. Am. J. Physiol. 260: E651–E661, 1991.
Marrama P., Carani C., Baraghini G.F., Volpe A., Zini D., Celani M.F., Montanini V.: Circadian rhythm of testosterone and prolactin in aging. Maturitas 4: 131–138, 1982.
Roland E., Magnani G., Sannia A., Barreca T.: Evaluation of PRL secretion in elderly subjects. Acta Endocrinol. (Co-penh.) 100: 351–357, 1982.
Krieger D.T., Silverberg A.I., Rizzo F., Krieger H.P.: Abolition of circadian periodicity of plasma 17-OH cs levels in the cat. Am J. Physiol. 215: 959–967, 1968.
Greenspan S.L., Klibanski A., Rowe J.W., Elahi D.: Age alters pulsatile prolactin release: influence of dopaminergic inhibition. Am. J. Physiol. 258: E799–E804, 1990.
Ferrari E., Bossolo P.A., Vailati A., Martinelli I., Rea A., Nosari I.: Variations circadiennes des effectes d’une substance vagolytique sur le système ACTH-secrétant chez l’homme. Ann. Endocrinol. (Paris) 38: 203–213, 1977.
Sapolsky R.M., Krey L.C., McEwen B.S.: The neuroendocri-nology of stress and aging: the glucocorticoid cascade hypothesis. Endocr. Rev. 7: 284–301, 1986.
Angelucci L., Patacchioli F.R., Scaccianoce S., Di Sciullo A., Catalani A., Taglialatela G., Ramacci M.T.: Hypothalamo-pituitary-adrenocortical function and process of brain aging. In: Nerozzi D., Goodwin F.K., Costa E. (Eds.), Hypotha-lamic Dysfunction in Neuropsychiatric Disorders. Raven Press, New York, 1987, pp. 293–304.
Kaplan A.S., Garfinkel P.E., Warsh J.J., Brown G.: Neuroen-docrine responses in bulimia. In: Ferrari E., Brambilla F. (Eds.), Disorders of eating behaviour: a psychoneuroendo-crine approach. Pergamon Press, Oxford, New York, 1986, pp. 241–245.
Wetterberg L.: The relationship between the pineal gland and the pituitary-adrenal axis in health, endocrine and psychiatric conditions. Psychoneuroendocrinology 8: 75–80, 1983.
Sachar E.J., Asnis G., Nathan S., Halbreich U., Tabrizi M.A., Halpern F.S.: Dextro-amphetamine and cortisol in depression. Morning plasma cortisol levels suppressed. Arch. Gen. Psychiatry 37: 755–757, 1980.
Tuomisto J., Mannisto P.: Neurotransmitter regulation of anterior pituitary hormones. Pharmacol. Rev. 37: 249–332, 1985.
Halbreich U.: The circadian rhythm of cortisol and MHPG in depressive and normal. In: Halaris A. (Ed.), Chronobiology and Psychiatric Disorders. Elsevier, Amsterdam, 1987, pp. 49–73.
Dickson K.L., Hasty D.L.: Effects of the pineal gland in unilaterally adrenalectomized rats. Acta Endocrinol. (Copenh.) 70: 438–442, 1972.
Chakraborty S.: Exogenous melatonin may act as a reproductive-phase dependent modulator of the relationship in morphology between pineal and adrenal cortex in male Blos-somheaded Parakeet (Psittacula cyanocephala) and Indian Weaver Bird (Ploceus philippinus). Biol. Rhythm Res. 25: 121–132, 1994.
Sanchez De La Pena S., Halberg F., Ungar F.: Pineal Chronomodulation- the feed-sideward. Clin. Chem. News-lett. 2: 129–135, 1982.
Milin J., Djakovic-Svajcer K., Demajo M.: Rat pineal gland suppresses the injection stress-reactive ACTH outflow. Horm. Metab. Res. 25:149–151, 1993.
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Ferrari, E., Magri, F., Locatelli, M. et al. Chrono-neuroendocrine markers of the aging brain. Aging Clin Exp Res 8, 320–327 (1996). https://doi.org/10.1007/BF03339588
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DOI: https://doi.org/10.1007/BF03339588