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Costi della gastroenterite da rotavirus acquisita in comunità in età pediatrica a Padova in Italia

Costs of pediatric community-acquired rotavirus gastroenteritis in Italy (Padua county)

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PharmacoEconomics Italian Research Articles

Summary

Background

Rotavirus gastroenteritis (RVGE) has a major impact in terms of morbidity in Italy. Comprehensive data on the economic impact are needed in order to evaluate the cost-effectiveness of a Rotavirus (RV) vaccination program.

Methods

As part of a prospective observational study (REVEAL) conducted in 2004–2005 in seven European countries, we calculated the average costs per case with confirmed RVGE in primary care (PC), emergency room (ER), and hospital (H) settings, from both the national health care service and societal perspectives.

Results

A total of 336 children <5 years with RVGE were included in the cost analysis. The total societal cost per child was € 292 in PC, € 600 in ER, and € 1,901 in the H setting. Overall total cost of community-acquired RVGE in the Veneto Region was estimated to be around 7 million €. Extrapolating the observed data to the whole Italian country, the total cost was estimated between 67.1–80 million € according to the estimates used. About 61% of the total costs were direct non-medical and indirect costs, mostly related to loss of productivity due to work days lost by parents and other caregivers.

Conclusions

RVGE in Italy causes considerable costs in all healthcare settings for the national health care payer and families. An effective childhood vaccination program would have considerable direct and indirect benefits for the Italian society.

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Bibliografia

  1. Parashar UD, Gibson CJ, Bresee JS, Glass RI. Rotavirus and severe childhood diarrhoea. Emerg Infect Dis 2006; 12: 304–6

    Article  PubMed  Google Scholar 

  2. Clark HF, Offitt PA. Vaccines for Rotavirus gastroenteritis universally needed for children. Pediatr Ann 2004; 338: 537–43

    Google Scholar 

  3. The Pediatric ROTavirus European CommitTee (PROTECT). The paediatric burden of rotavirus disease in Europe. Epidemiol Infect 2006; 134: 908–16

    Article  Google Scholar 

  4. Soriano-Gabarro M, Mrukowicz J, Vesikari T, Verstraeten T. Burden of rotavirus disease in European Union countries. Pediatr Infect Dis J 2006; 25(1 Suppl.): S7–11

    PubMed  Google Scholar 

  5. Giaquinto C, Callegaro S, Andreola B, et al. Prospective study of the burden of acute gastroenteritis in children less than 5 years in Italy. Riv Ital Pediatr 2007, in corso di stampa

    Google Scholar 

  6. Vesikari T, Matson DO, Dennehy P, et al. (Rotavirus Efficacy and Safety Trial Study Team). Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med 2006; 354: 23–33

    Article  PubMed  CAS  Google Scholar 

  7. Ruiz-Palacios GM, Pérez-Schael I, Velasquez FR, et al. (Human Rotavirus Vaccine Group Study). Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med 2006; 354: 11–22

    Article  PubMed  CAS  Google Scholar 

  8. Van Damme P, Van der Wielen M, Ansaldi F, et al. Rotavirus vaccines: considerations for successful implementation in Europe. Lancet Infect Dis 2006; 6: 805–12

    Article  PubMed  Google Scholar 

  9. Piednoir E, Bessaci K, Bureau-Chalot F, et al. Economic impact of healthcare associated rotavirus infection in a pediatric hospital. J Hosp Infect 2003; 55: 190–5

    Article  PubMed  CAS  Google Scholar 

  10. Fruhwirth M, Berger K, Ehlken B, et al. Economic impact of community and nosocomially acquired Rotavirus gastroenteritis in Austria. Pediatr Infect Dis J 2001; 20: 184–8

    Article  PubMed  CAS  Google Scholar 

  11. Vesikari T, Rautanen T, Von Bonsdorff CH. Rotavirus gastroenteritis in Finland: burden of disease and epidemiological features. Acta Paediatr Suppl 1999; 88: 24–30

    Article  CAS  Google Scholar 

  12. Visser LE, Portero RC, Gay NJ, Navarro LFM. Impact of rotavirus disease in Spain: an estimate of hospital admissions due to rotavirus. Acta Paediatr Suppl 1999; 88: 72–6

    Article  PubMed  CAS  Google Scholar 

  13. Fontana M, Zuin G, Pancheri P, et al. Costs associated with outpatients diarrhoea in infants and toddlers: a nationwide study of Italian Society of Pediatric Gastroenterology and Hepatology (SIGEP). Dig Liver Dis 2004; 36: 523–7

    Article  PubMed  CAS  Google Scholar 

  14. Lorgelly PK, Joshi D, Iturriza Gómara M, et al. Infantile gastroenteritis in the community: a cost of illness study. Poster presented at the 23rd Annual Meeting of the European Society for Paediatric Infectious Diseases. Valencia, Spain, May 18–20, 2005.

  15. Melliez H, Boelle P-Y, Baron S, et al. Morbidity and cost of rotavirus infections in France [in French]. Méd Mal Infect 2005; 35: 492–9

    Article  PubMed  CAS  Google Scholar 

  16. Roberts JA, Cumberland P, Sockett PN, et al. The study of infectious intestinal disease in England: socio-economic impact. Epidemiol Infect 2003; 130: 1–11

    Article  PubMed  CAS  Google Scholar 

  17. Hammerschmidt T, Gartner B. Acute Rotavirus Gastroenteritis: burden of disease and cost of illness among young children in Germany. Value Health 2004; 7: 762

    Article  Google Scholar 

  18. Johansen K, Bennet R, Bondesson K, et al. Incidence and estimates of the disease burden of rotavirus in Sweden. Acta Paediatr Suppl 1999; 88: 20–3

    Article  CAS  Google Scholar 

  19. Takala AK, Koskenniemi E, Joensuu J, et al. Economic evaluation of Rotavirus vaccinations in Finland: randomized double-blind placebo controlled trial of tetravalent rhesus rotavirus vaccine. Clin Infect Dis 1998; 88: 24–30

    Google Scholar 

  20. Van Damme P, Giaquinto C, Huet F, et al. Multicentre prospective study of the burden of rotavirus acute gastroenteritis in Europe 2004–2005: the REVEAL Study. J Infect Dis 2007; 195 (Suppl. 1): S1–6

    Google Scholar 

  21. Giaquinto C, Van Damme P, Huet F, et al. Clinical impact of rotavirus acute gastroenteritis in Europe 2004–2005: the REVEAL Study. J Infect Dis 2007; 195 (Suppl. 1): S26–35

    Article  PubMed  Google Scholar 

  22. Ward RL, McNeal MM, Clemens JD, et al. Reactivities of serotyping monoclonal antibodies with culture-adapted human rotaviruses. J Clin Microbiol 1991; 29: 449–56

    PubMed  CAS  Google Scholar 

  23. Ministero della Salute. Aggiornamento delle tariffe delle prestazioni di assistenza ospedaliera di cui al DM 14.12.1994; DM 30.6.1997, suppl. ord. GU n. 209 dell’8.9.1997

  24. Coudeville L, Brunot A, Giaquinto C, et al. Varicella vaccination in Italy: an economic evaluation of different scenarios. Pharmacoeconomics 2004; 22: 839–55

    Article  PubMed  Google Scholar 

  25. Lucioni C, Garancini MP, Massi-Benedetti M, et al. Il costo sociale del diabete di tipo 2 in Italia: lo studio CODE-2. Pharmacoeconomics-Italian Research Articles 2000; 2: 1–21

    Google Scholar 

  26. Ministero della Salute. Tariffe Nazionali Ambulatoriali. DM 22.7.1996, GU n. 216 del 4.11.1996

    Google Scholar 

  27. Banca d’Italia. Assemblea generale ordinaria dei partecipanti, 31 maggio 2005

  28. Lucioni C, Alliata E, Mazzi S, Lizioli A. I costi della meningite pneumococcica in età pediatrica. Pharmacoeconomics-Italian Research Articles 2005; 7: 177–86

    Google Scholar 

  29. Ministero della Salute. Diagnosis Related Groups. www.drg.it

  30. World Health Organization. The Anatomical Therapeutic Chemical Classification System with Defined Daily Doses (ATC/DDD) www.who.int/classifications/atcddd/en/.

  31. Giaquinto C, Van Damme P, Huet F, et al. Cost of community acquired pediatric Rotavirus gastroenteritis in seven European countries: the REVEAL study. J Infect Dis 2007; 195 (Suppl. 1): S36–44

    Article  PubMed  Google Scholar 

  32. UNICEF, Italy (2004) www.unicef.org/infobycountry/italy.html

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Giaquinto, C., Callegaro, S., Andreola, B. et al. Costi della gastroenterite da rotavirus acquisita in comunità in età pediatrica a Padova in Italia. Pharmacoeconomics-Ital-Res-Articles 9, 103–111 (2007). https://doi.org/10.1007/BF03320704

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  • DOI: https://doi.org/10.1007/BF03320704

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