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In vitro andin vivo application of PLGA nanofiber for artificial blood vessel

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Abstract

Poly(lactic-co-glycolic acid) (PLGA) tubes (5 mm in diameter) were fabricated using an electro spinning method and used as a scaffold for artificial blood vessels through the hybridization of smooth muscle cells (SMCs) and endothelial cells (ECs) differentiated from canine bone marrow under previously reported conditions. The potential clinical applications of these artificial blood vessels were investigated using a canine model. From the results, the tubular-type PLGA scaffolds for artificial blood vessels showed good mechanical strength, and the duallayered blood vessels showed acceptable hybridization behavior with ECs and SMCs. The artificial blood vessels were implanted and substituted for an artery in an adult dog over a 3-week period. The hybridized blood vessels showed neointimal formation with good patency. However, the control vessel (unhybridized vessel) was occluded during the early stages of implantation. These results suggest a shortcut for the development of small diameter, tubular-type, nanofiber blood vessels using a biodegradable material (PLGA).

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Author notes

  1. You Sun Hong

    Present address: Department of Thoracic and Cardiovascular Surgery, School of Medicine, Ajou University, 443-721, Suwon, Korea

Authors and Affiliations

  1. Department of Polymer Science & Engineering, Sungkyunkwan University, 440-746, Suwon, Korea

    Mi Jin Kim & Dong June Chung

  2. Department of Chemical Engineering, Sungkyunkwan University, 440-746, Suwon, Korea

    Ji-Heung Kim

  3. Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yonsei University, 120-752, Seoul, Korea

    Gijong Yi

  4. Department of Thoracic and Cardiovascular Surgery, School of Medicine, Ajou University, 443-721, Suwon, Korea

    Sang-Hyun Lim

  5. Division of Cardiovascular Surgery, Cardiovascular Center, College of Medicine, Yonsei University, 120-752, Seoul, Korea

    You Sun Hong

  6. Intellectual Biointerface Engineering Center, Seoul National University, 110-749, Seoul, Korea

    Dong June Chung

Authors
  1. Mi Jin Kim
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  2. Ji-Heung Kim
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  3. Gijong Yi
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  4. Sang-Hyun Lim
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  5. You Sun Hong
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Correspondence to Dong June Chung.

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Kim, M.J., Kim, JH., Yi, G. et al. In vitro andin vivo application of PLGA nanofiber for artificial blood vessel. Macromol. Res. 16, 345–352 (2008). https://doi.org/10.1007/BF03218527

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  • DOI: https://doi.org/10.1007/BF03218527

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