Abstract
Our purpose was to evaluate the hemodynamic effects of olprinone hydrochloride early after coronary artery bypass grafting (CABG). Fifteen patients undergoing CABG were administered a constant infusion of 0.1 μg/kg/min of olprinone and continued for 4 hours. No bolus infusion of olprinone was administered before continuous infusion. Systolic systemic arterial pressure, systolic pulmonary arterial pressure, systemic vascular resistance and pulmonary vascular resistance were significantly decreased. There were no significant changes in heart rate, mean central venous pressure, mean left atrial pressure and left ventricular stroke work index. Cardiac index was significantly increased, but a correlation between cardiac index and mixed venous blood oxygen saturation was not found. Double product was significantly decreased, which described above suggest that olprinone achieved improvement of left cardiac function without more myocardial oxygen consumption. Severe transient hypotension (systolic arterial pressure <80 mmHg) after infusion of olprinone was observed in three patients. Olprinone administered soon after CABG surgery had beneficial effects in terms of improvement of hemodynamic status without more oxygen consumption and reduction of pulmonary vascular resistance. However transient hypotension was a serious clinical problem in patients after open heart surgery, especially in CABG patients who need suitable systolic arterial pressure to keep enough blood perfusion of arterial bypass grafts.
Similar content being viewed by others
References
Pozen RG, DiBianco R, Katz RJ, Bortz R, Myerburg RJ, Fletcher RD: Myocardial metabolic and hemodynamic effects of dobutamine in heart failure complicating coronary artery disease. Circulation 63: 1279–1285, 1981
Unverferth DV, Blanford M, Kates RE, Leier CV: Tolerance to dobutamine after a 72 hour continuous infusion. Am J Med 69: 262–266, 1980
Bristow MR, Ginsburg R, Minobe W, Cubicciotti RS, Sageman WS, Lurie K, Billingham ME, Harrison DC, Stinson EB: Decreased catecholamine sensitivity and β-adrenergic-receptor density in failing human hearts. N Engl J Med 307: 205–211, 1982
(3)—Placebo. 70: 903–916, 1993
Loprinone(E-1020). 99: 421–433, 1992
Hess W: Effects of amrinone on the right side of the heart. J Cardiothorac Anesth 3: 38–44, 1989
Richrd C, Thuillez C, Pezzano M, Bottineau G, Giudicelli JF, Auzepy P: Relationship between mixed venous oxygen saturation and cardiac index in patients with chronic cngestive heart failure. Chest 95: 1289–1294, 1989
Prielipp RC, Butterworth JF, Zaloga GP, Robertie PG, Royster RL: Effects of amrinone on cardiac index, venous oxygen saturation and venous admixture in patients recovering from cardiac surgery. Chest 99: 820–825, 1991
E-1020. 69: 2260–2274, 1992
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Marui, A., Mochizuki, T., Mitsui, N. et al. Early hemodynamic effects of olprinone hydrochloride after coronary artery bypass grafting. Jpn J Thorac Caridovasc Surg 46, 1112–1116 (1998). https://doi.org/10.1007/BF03217885
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03217885