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Effect of Sodium/Potassium Salt (Potash) on the bioavailability of ibuprofen in healthy human volunteers

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Summary

The influence of sodium/potassium salt water extract incorporated in a traditional meal on the bioavailability of Ibuprofen tablets 400mg dose was studied in 6 healthy human volunteers. There was a statistically significant decrease in the plasma levels of ibuprofen, and its metabolites, hydroxy-ibuprofen and carboxy-ibuprofen, respectively, when the meal containing sodium/potassium salt extract was administered with the ibuprofen tablets than when taken under fasting state or with the meal without the fruit extract. The Cmax, AUC0–6hr and Ka for ibuprofen decreased from 38.04±0.70μg/ml to 20.06±1.21μg/ml (p<0.05); 28.030±2.40μg/ml.hr to 14.180±1.12μg/ml.hr (p<0.05) and 1.048±0.02hr−1 to 0.602±0.03hr−1. Similarly, the Cmax for hydroxy-ibuprofen and carboxy-ibuprofen decreases from 43.04±0.76μg/ml to 27.21±0.24μg/ml (p<0.05) and 48±0.71μg/ml to 31.08±0.12μg/ml (p<0.05) respectively; while AUC0–6hr for hydroxy-ibuprofen decreased from 34.120±0.49μg/ml.hr to 16.410±0.27μg/ml.hr while that of carboxy-ibuprofen decreased from 36.121±1.97μg/ml.hr to 19.278±0.92μg/ml.hr respectively. The Kel for hydroxy-ibuprofen increased from 0.71±0.94 hr−1 to 0.81±0.21 hr−1 (p<0.05) respectively. The study has indicated tha sodium/potassium salt extract significantly decreased the bioavailability of ibuprofen.

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Authors and Affiliations

  1. Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria

    I. A. Yakasai

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  1. I. A. Yakasai
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Yakasai, I.A. Effect of Sodium/Potassium Salt (Potash) on the bioavailability of ibuprofen in healthy human volunteers. Eur. J. Drug Metab. Pharmacokinet. 28, 93–99 (2003). https://doi.org/10.1007/BF03190495

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  • DOI: https://doi.org/10.1007/BF03190495

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