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Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma

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Summary

Experimental chronic renal insufficiency (produced by 5/6 ablation of renal parenchyma) is associated with changes in the kinetics of oral (intragastric) cyclosporine A (CyA). Compared with animals with intact renal parenchyma, significantly lower levels of CyA are reached under these conditions. The factors resonsible for reduced CyA availability under these conditions have not yet been identified.

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Authors and Affiliations

  1. Institute for Clinical and Experimental Medicine, Vídenská 800, 14000, Prague 4, Czech Republic

    O. Schück MD DSc, M. Bohdanecká, J. Šedivý, M. Krajíčková, M. Chadimová & K. Matoušovic

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  1. O. Schück MD DSc
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  2. M. Bohdanecká
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  3. J. Šedivý
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  4. M. Krajíčková
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  5. M. Chadimová
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  6. K. Matoušovic
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Schück, O., Bohdanecká, M., Šedivý, J. et al. Changes in cyclosporine A kinetics after experimental reduction of renal parenchyma. European Journal of Drug Metabolism and Pharmacokinetics 22, 207–209 (1997). https://doi.org/10.1007/BF03189808

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  • DOI: https://doi.org/10.1007/BF03189808

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