Summary
Pharmacokinetics of Drotaverine-Acephyllinate, Chinoin was investigated in seven male volunteers using14C labelled drug. Drotaverine-Acephyllinate was administered at a 100 mg single oral dose. Measurements of total radioactivity showed that the drug was absorbed completely and was eliminated by renal and biliary routes. Within 72 hours 39.9 ± 9.9% and 47.1 ± 4.9% of the dose were recovered in the urine and faeces respectively. Experimental results were interpreted on the basis of a complex linear compartment model. The structural identifiability of the model was proved by computer analysis, and the pharmacokinetic parameters were determined.
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Vargay, Z., Deutsch, T., Szatmári, I. et al. The fate of Drotaverine-Acephyllinate in rat and man II. Human pharmacokinetics of Drotaverine-14C-Acephyllinate. European Journal of Drug Metabolism and Pharmacokinetics 9, 17–29 (1984). https://doi.org/10.1007/BF03189602
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DOI: https://doi.org/10.1007/BF03189602