Abstract
This study proposes a new solution for the quantification of rCBF pixel-by-pixel using PET and15O-H2O. The method represents an application of weighted integration that uses PET image only, requiring no input function of arterial blood. It generates the rCBF image quickly and automatically. Simulation studies revealed that the calculation of rCBF was fairly stable as long as a relatively shorter scan frame time and longer scan time were selected. Calculated images of actual PET study by this method correlated significantly with those identified by the dynamic/integral method. Because this procedure could detect whole brain CBF change between different studies as accurately as by the dynamic/integral method, this procedure may be the most suitable for brain activation studies.
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Frackowiak RSJ, Lenzi GL, Jones T, Heather JD. Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using15O and positron emission tomography: theory, procedure, and normal values.J Comput Assist Tomogr 4: 727–736, 1980.
Huang SC, Carson RE, Hoffman EJ, Carson J, MacDonald N, Barrio JR, et al. Quantitative measurement of local cerebral blood flow in humans by positron computed tomography and15O-water.J Cereb Blood Flow Metab 3: 141–153, 1983.
Raichle ME, Martin WRW, Herscovitch P, Mintun MA, Markham J. Brain blood flow measured with intravenous H2 15O. II. Implementation and validation.J Nucl Med 29: 241–247, 1983.
Kanno I, Lammertsma AA, Heather JD, Gibbs JM, Rhodes CG, Clark JC, et al. Measurement of cerebral blood flow using bolus inhalation of C15O2 and positron emission tomography: description of the method and its comparison with the C15O2 continuous inhalation method.J Cereb Blood Flow Metab 4: 224–234, 1984.
Lammertsma AA, Frackowiak RSJ, Hoffman JM, Huang SC, Weinberg IN, Dahlbom M, et al. The C15O2 build-up technique to measure regional cerebral blood flow and volume of distribution of water.J Cereb Blood Flow Metab 9: 461–470, 1989.
Lammertsma AA, Cunningham VJ, Deiber MP, Heather JD, Bloomfield PM, Nutt J, et al. Combination of Dynamic and Integral Methods for Generating Reproducible Functional CBF Images.J Cereb Blood Flow Metab 10: 675–686, 1990.
Iida H, Kanno I, Miura S, Murakami M, Takahashi K, Uemura K. Error analysis of a quantitative cerebral blood flow measurement using H2 15O autoradiography and positron emission tomography, with respect to the dispersion of the input function.J Cereb Blood Flow Metab 6: 536–545, 1986.
Huang SC, Carson RE, Phelps ME. Measurement of local blood flow and distribution volume with short-lived isotopes: A general input technique.J Cereb Blood Flow Metabol 2: 99–108, 1982.
Kety SS. The theory and applications of the exchange of inert gas at the lungs and tissues.Pharmacol Rev 3: 1–41, 1951.
Spinks TJ, Jones T, Gilardi MC, Heather JD. Physical performance of the latest generation of commercial positron scanner.IEEE Trans Nucl Sci NS 35: 721–725, 1988.
Alpert NM, Eriksson L, Chang JY, Bergstrom M, Litton JE, Correia JA, et al. Strategy for the measurement of regional cerebral blood flow using short-lived tracers and emission tomography.J Cereb Blood Flow Metab 4: 28–34, 1984.
Gambhir SS, Huang SC, Hawkins RA, Phelps ME. A study of the single compartment tracer kinetic model for the measurement of local cerebral blood flow using15O-water and positron emission tomography.J Cereb Blood Flow Metab 7: 13–20, 1987.
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Watabe, H., Itoh, M., Mejia R., M. et al. Validation of noninvasive quantification of rCBF compared with dynamic/integral method by using positron emission tomography and oxygen-15 labeled water. Ann Nucl Med 9, 191–198 (1995). https://doi.org/10.1007/BF03168400
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DOI: https://doi.org/10.1007/BF03168400